2I3I
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Summary for 2I3I
Entry DOI | 10.2210/pdb2i3i/pdb |
Related | 1OXN 1OXQ 1OY7 1TW6 |
Descriptor | Baculoviral IAP repeat-containing protein 7, ZINC ION, (3R,6R,9AR)-2,2-DIMETHYL-6-[(N-METHYL-L-ALANYL)AMINO]-N-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)-5-OXO-2,3,5,6,9,9A-HEXAHYDRO[1,3]THIAZOLO[3,2-A]AZEPINE-3-CARBOXAMIDE, ... (7 entities in total) |
Functional Keywords | zinc binding, peptide complex, apoptosis inhibition, peptidomimetic, small molecule, drug design, inhibitor-apoptosis complex, inhibitor/apoptosis |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q96CA5 |
Total number of polymer chains | 2 |
Total formula weight | 31419.52 |
Authors | Fairbrother, W.J.,Franklin, M.C. (deposition date: 2006-08-18, release date: 2006-09-19, Last modification date: 2024-04-03) |
Primary citation | Zobel, K.,Wang, L.,Varfolomeev, E.,Franklin, M.C.,Elliott, L.O.,Wallweber, H.J.,Okawa, D.C.,Flygare, J.A.,Vucic, D.,Fairbrother, W.J.,Deshayes, K. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. Acs Chem.Biol., 1:525-533, 2006 Cited by PubMed: 17168540DOI: 10.1021/cb600276q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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