1TW6
Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac
Summary for 1TW6
Entry DOI | 10.2210/pdb1tw6/pdb |
Related | 1NW9 1OXN 1OXQ 1OY7 |
Descriptor | Baculoviral IAP repeat-containing protein 7, Diablo homolog, mitochondrial, ZINC ION, ... (7 entities in total) |
Functional Keywords | zinc binding, peptide complex, apoptosis inhibition, inhibitor-apoptosis complex, inhibitor/apoptosis |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q96CA5 Mitochondrion: Q9NR28 |
Total number of polymer chains | 4 |
Total formula weight | 32280.51 |
Authors | Franklin, M.C.,Vucic, D.,Wallweber, H.J.A.,Das, K.,Shin, H.,Elliott, L.O.,Kadkhodayan, S.,Deshayes, K.,Salvesen, G.S.,Fairbrother, W.J. (deposition date: 2004-06-30, release date: 2004-11-02, Last modification date: 2023-08-23) |
Primary citation | Vucic, D.,Franklin, M.C.,Wallweber, H.J.A.,Das, K.,Eckelman, B.P.,Shin, H.,Elliott, L.O.,Kadkhodayan, S.,Deshayes, K.,Salvesen, G.S.,Fairbrother, W.J. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP Biochem.J., 385:11-20, 2005 Cited by PubMed: 15485396DOI: 10.1042/BJ20041108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.713 Å) |
Structure validation
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