2I3H

Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW)

Summary for 2I3H

• Entry DOI: 10.2210/pdb2i3h/pdb
• Related: 1OXN 1OXQ 1OY7 1TW6
• Descriptor: Baculoviral IAP repeat-containing protein 7, AVPW peptide, ZINC ION, ... (7 entities in total)
• Functional Keywords: zinc binding, peptide complex, apoptosis inhibition, peptidomimetic, small molecule, drug design, inhibitor-apoptosis complex, inhibitor/apoptosis
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q96CA5
• Total number of polymer chains: 4
• Total formula weight: 31369.36

Authors

Fairbrother, W.J.,Franklin, M.C. (deposition date: 2006-08-18, release date: 2006-09-19, Last modification date: 2024-04-03)

• Primary citation: Zobel, K.,Wang, L.,Varfolomeev, E.,Franklin, M.C.,Elliott, L.O.,Wallweber, H.J.,Okawa, D.C.,Flygare, J.A.,Vucic, D.,Fairbrother, W.J.,Deshayes, K.; Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.; Acs Chem.Biol., 1:525-533, 2006; PubMed: 17168540; DOI: 10.1021/cb600276q

Experimental method

X-RAY DIFFRACTION (1.62 Å)