6AH0
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![BU of 6ah0 by Molmil](/molmil-images/mine/6ah0) | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhan, X, Yan, C, Zhang, X, Shi, Y. | Deposit date: | 2018-08-15 | Release date: | 2018-11-14 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Res., 28, 2018
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1NUU
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![BU of 1nuu by Molmil](/molmil-images/mine/1nuu) | CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE COMPLEXED WITH NAD | Descriptor: | FKSG76, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION | Authors: | Zhang, X, Kurnasov, O.V, Karthikeyan, S, Grishin, N.V, Osterman, A.L, Zhang, H. | Deposit date: | 2003-02-01 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN
ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS J.Biol.Chem., 278, 2003
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1NUT
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![BU of 1nut by Molmil](/molmil-images/mine/1nut) | CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE COMPLEXED WITH ATP ANALOG | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, FKSG76, SULFATE ION | Authors: | Zhang, X, Kurnasov, O.V, Karthikeyan, S, Grishin, N.V, Osterman, A.L, Zhang, H. | Deposit date: | 2003-02-01 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN
ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS J.Biol.Chem., 278, 2003
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1NUS
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![BU of 1nus by Molmil](/molmil-images/mine/1nus) | CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE COMPLEXED WITH ATP ANALOG AND NMN | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, FKSG76, ... | Authors: | Zhang, X, Kurnasov, O.V, Karthikeyan, S, Grishin, N.V, Osterman, A.L, Zhang, H. | Deposit date: | 2003-02-01 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN
ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS J.Biol.Chem., 278, 2003
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1NUP
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![BU of 1nup by Molmil](/molmil-images/mine/1nup) | CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE COMPLEX WITH NMN | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, FKSG76, SULFATE ION | Authors: | Zhang, X, Kurnasov, O.V, Karthikeyan, S, Grishin, N.V, Osterman, A.L, Zhang, H. | Deposit date: | 2003-02-01 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN
ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS J.Biol.Chem., 278, 2003
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1NUQ
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![BU of 1nuq by Molmil](/molmil-images/mine/1nuq) | CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE COMPLEXED WITH NaAD | Descriptor: | FKSG76, NICOTINIC ACID ADENINE DINUCLEOTIDE, SULFATE ION | Authors: | Zhang, X, Kurnasov, O.V, Karthikeyan, S, Grishin, N.V, Osterman, A.L, Zhang, H. | Deposit date: | 2003-02-01 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN
ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS J.Biol.Chem., 278, 2003
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1HQK
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![BU of 1hqk by Molmil](/molmil-images/mine/1hqk) | CRYSTAL STRUCTURE ANALYSIS OF LUMAZINE SYNTHASE FROM AQUIFEX AEOLICUS | Descriptor: | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE | Authors: | Zhang, X, Meining, W, Fischer, M, Bacher, A, Ladenstein, R. | Deposit date: | 2000-12-18 | Release date: | 2001-12-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons. J.Mol.Biol., 306, 2001
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7MDO
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![BU of 7mdo by Molmil](/molmil-images/mine/7mdo) | Structure of human p97 ATPase L464P mutant | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Zhang, X, Gui, L, Li, S, Nandi, P, Columbres, R.C, Wong, D.E, Moen, D.R, Lin, H.J, Chiu, P.-L, Chou, T.-F. | Deposit date: | 2021-04-05 | Release date: | 2021-08-25 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.12 Å) | Cite: | Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity. Biochem.J., 478, 2021
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7MDM
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![BU of 7mdm by Molmil](/molmil-images/mine/7mdm) | Structure of human p97 ATPase L464P mutant | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Zhang, X, Gui, L, Li, S, Nandi, P, Columbres, R.C, Wong, D.E, Moen, D.R, Lin, H.J, Chiu, P.-L, Chou, T.-F. | Deposit date: | 2021-04-05 | Release date: | 2021-08-25 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.86 Å) | Cite: | Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity. Biochem.J., 478, 2021
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5HWL
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![BU of 5hwl by Molmil](/molmil-images/mine/5hwl) | Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form | Descriptor: | GLUTATHIONE, Glutathione S-transferase Mu 2, N,N'-(butane-1,4-diyl)bis{2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetamide} | Authors: | Zhang, X, Wei, J, Wu, S, Zhang, H.P, Luo, M, Yang, X.L, Liao, F, Wang, D.Q. | Deposit date: | 2016-01-29 | Release date: | 2017-11-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form To Be Published
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1KJS
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![BU of 1kjs by Molmil](/molmil-images/mine/1kjs) | NMR SOLUTION STRUCTURE OF C5A AT PH 5.2, 303K, 20 STRUCTURES | Descriptor: | C5A | Authors: | Zhang, X, Boyar, W, Toth, M, Wennogle, L, Gonnella, N.C. | Deposit date: | 1997-01-09 | Release date: | 1997-05-15 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy. Proteins, 28, 1997
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1NQW
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![BU of 1nqw by Molmil](/molmil-images/mine/1nqw) | Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 5-(6-D-ribitylamino-2,4(1H,3H)pyrimidinedione-5-yl)-1-pentyl-phosphonic acid | Descriptor: | 5-(6-D-RIBITYLAMINO-2,4(1H,3H)PYRIMIDINEDIONE-5-YL) PENTYL-1-PHOSPHONIC ACID, 6,7-dimethyl-8-ribityllumazine synthase | Authors: | Zhang, X, Meining, W, Cushman, M, Haase, I, Fischer, M, Bacher, A, Ladenstein, R. | Deposit date: | 2003-01-23 | Release date: | 2004-01-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. J.Mol.Biol., 328, 2003
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1NQX
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![BU of 1nqx by Molmil](/molmil-images/mine/1nqx) | Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid | Descriptor: | 3-(7-HYDROXY-8-RIBITYLLUMAZINE-6-YL) PROPIONIC ACID, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | Authors: | Zhang, X, Meining, W, Cushman, M, Haase, I, Fischer, M, Bacher, A, Ladenstein, R. | Deposit date: | 2003-01-23 | Release date: | 2004-01-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. J.Mol.Biol., 328, 2003
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3IYK
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![BU of 3iyk by Molmil](/molmil-images/mine/3iyk) | Bluetongue virus structure reveals a sialic acid binding domain, amphipathic helices and a central coiled coil in the outer capsid proteins | Descriptor: | 2-O-methyl-5-N-acetyl-alpha-D-neuraminic acid, VP2, VP5 | Authors: | Zhang, X, Boyce, M, Bhattacharya, B, Zhang, X, Schein, S, Roy, P, Zhou, Z.H. | Deposit date: | 2010-01-25 | Release date: | 2010-04-07 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Bluetongue virus coat protein VP2 contains sialic acid-binding domains, and VP5 resembles enveloped virus fusion proteins. Proc.Natl.Acad.Sci.USA, 107, 2010
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1NQU
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![BU of 1nqu by Molmil](/molmil-images/mine/1nqu) | Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 6,7-dioxo-5H-8-ribitylaminolumazine | Descriptor: | 6,7-DIOXO-5H-8-RIBITYLAMINOLUMAZINE, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | Authors: | Zhang, X, Meining, W, Cushman, M, Haase, I, Fischer, M, Bacher, A, Ladenstein, R. | Deposit date: | 2003-01-23 | Release date: | 2004-01-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. J.Mol.Biol., 328, 2003
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1NQV
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![BU of 1nqv by Molmil](/molmil-images/mine/1nqv) | Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 5-nitroso-6-ribityl-amino-2,4(1H,3H)pyrimidinedione | Descriptor: | 5-NITROSO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | Authors: | Zhang, X, Meining, W, Cushman, M, Haase, I, Fischer, M, Bacher, A, Ladenstein, R. | Deposit date: | 2003-01-23 | Release date: | 2004-01-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. J.Mol.Biol., 328, 2003
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3J27
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![BU of 3j27 by Molmil](/molmil-images/mine/3j27) | CryoEM structure of Dengue virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, ... | Authors: | Zhang, X, Ge, P, Yu, X, Brannan, J.M, Bi, G, Zhang, Q, Schein, S, Zhou, Z.H. | Deposit date: | 2012-09-26 | Release date: | 2012-12-19 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the mature dengue virus at 3.5-A resolution. Nat.Struct.Mol.Biol., 20, 2012
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3AH5
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![BU of 3ah5 by Molmil](/molmil-images/mine/3ah5) | Crystal Structure of flavin dependent thymidylate synthase ThyX from helicobacter pylori complexed with FAD and dUMP | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... | Authors: | Zhang, X, Zhang, J, Hu, Y, Zou, Q, Wang, D. | Deposit date: | 2010-04-14 | Release date: | 2011-04-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure and functional analysis of a flavin dependent thymidylate synthase from helicobacter pylori To be Published
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2P0Q
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![BU of 2p0q by Molmil](/molmil-images/mine/2p0q) | |
8SG1
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![BU of 8sg1 by Molmil](/molmil-images/mine/8sg1) | Cryo-EM structure of CMKLR1 signaling complex | Descriptor: | CHOLESTEROL, Chemerin 9, Chemerin-like receptor 1, ... | Authors: | Zhang, X, Zhang, C. | Deposit date: | 2023-04-11 | Release date: | 2023-11-01 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural basis of G protein-Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist. Plos Biol., 21, 2023
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2P0P
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![BU of 2p0p by Molmil](/molmil-images/mine/2p0p) | Calcium binding protein in the free form | Descriptor: | Alr1010 protein | Authors: | Zhang, X, Hu, Y, Jin, C. | Deposit date: | 2007-02-28 | Release date: | 2008-03-25 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution Structures of Ccbp from Anabaena Reveals a New Fold and Novel Calcium Binding Sites To be Published
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2RFD
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![BU of 2rfd by Molmil](/molmil-images/mine/2rfd) | Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide | Descriptor: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor, SULFATE ION | Authors: | Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J. | Deposit date: | 2007-09-28 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450, 2007
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2RF9
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![BU of 2rf9 by Molmil](/molmil-images/mine/2rf9) | Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide | Descriptor: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor | Authors: | Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J. | Deposit date: | 2007-09-28 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450, 2007
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3J2P
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![BU of 3j2p by Molmil](/molmil-images/mine/3j2p) | CryoEM structure of Dengue virus envelope protein heterotetramer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, ... | Authors: | Zhang, X, Ge, P, Yu, X, Brannan, J.M, Bi, G, Zhang, Q, Schein, S, Zhou, Z.H. | Deposit date: | 2012-11-30 | Release date: | 2012-12-19 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the mature dengue virus at 3.5-A resolution. Nat.Struct.Mol.Biol., 20, 2012
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2Y3A
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![BU of 2y3a by Molmil](/molmil-images/mine/2y3a) | Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 | Descriptor: | 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM | Authors: | Zhang, X, Vadas, O, Perisic, O, Williams, R.L. | Deposit date: | 2010-12-20 | Release date: | 2011-03-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism. Mol.Cell, 41, 2011
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