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5KHJ
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BU of 5khj by Molmil
HCN2 CNBD in complex with uridine-3', 5'-cyclic monophosphate (cUMP)
Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Uridine-3',5'-cyclic monophosphate
Authors:Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
Deposit date:2016-06-14
Release date:2016-09-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
5KHK
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BU of 5khk by Molmil
HCN2 CNBD in complex with 2-aminopurine riboside-3', 5'-cyclic monophosphate (2-NH2-cPuMP)
Descriptor: 2-Aminopurine riboside-3',5'-cyclic monophosphate, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
Deposit date:2016-06-14
Release date:2016-09-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
5KHG
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BU of 5khg by Molmil
HCN2 CNBD in complex with cytidine-3', 5'-cyclic monophosphate (cCMP)
Descriptor: 4-amino-1-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1H)-one, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
Deposit date:2016-06-14
Release date:2016-09-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.241 Å)
Cite:Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
5KHH
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BU of 5khh by Molmil
HCN2 CNBD in complex with inosine-3', 5'-cyclic monophosphate (cIMP)
Descriptor: Inosine-3',5'-cyclic monophosphate, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
Deposit date:2016-06-14
Release date:2016-09-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
6DLG
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BU of 6dlg by Molmil
Crystal structure of a SHIP1 surface entropy reduction mutant
Descriptor: ISOPROPYL ALCOHOL, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Authors:Gardill, B.R, Cheung, S.T, Mui, A.L, Van Petegem, F.
Deposit date:2018-06-01
Release date:2019-06-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.499 Å)
Cite:Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes
Biorxiv, 2020
5C33
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BU of 5c33 by Molmil
Crystal Structure of Mouse Ryanodine Receptor 2 SPRY1 Domain
Descriptor: CHLORIDE ION, ISOPROPYL ALCOHOL, Ryanodine receptor 2
Authors:Yuchi, Z, Van Petegem, F.
Deposit date:2015-06-16
Release date:2015-08-05
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.
Nat Commun, 6, 2015
5C30
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BU of 5c30 by Molmil
Crystal Structure of Rabbit Ryanodine Receptor 1 Repeat12 Domain
Descriptor: ISOPROPYL ALCOHOL, Ryanodine receptor 1
Authors:Yuchi, Z, Van Petegem, F.
Deposit date:2015-06-16
Release date:2015-08-05
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.
Nat Commun, 6, 2015
4KEI
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BU of 4kei by Molmil
Crystal structure of mouse Ryanodine Receptor 2 (1-217) disease mutant P164S
Descriptor: Ryanodine receptor 2
Authors:Kimlicka, L, Van Petegem, F.
Deposit date:2013-04-25
Release date:2013-09-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.406 Å)
Cite:Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic alpha-Helix That Transitions to a beta-Strand in a Mutant Linked with a Heritable Cardiomyopathy.
J.Mol.Biol., 425, 2013
5DZG
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BU of 5dzg by Molmil
Crystal Structure of the catalytic nucleophile mutant of VvEG16 in complex with a xyloglucan tetradecasaccharide
Descriptor: VvEG16, endo-glucanase, alpha-D-xylopyranose-(1-6)-beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ...
Authors:McGregor, N.G.S, Tung, C.C, Van Petegem, F, Brumer, H.
Deposit date:2015-09-25
Release date:2016-09-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystallographic insight into the evolutionary origins of xyloglucan endotransglycosylases and endohydrolases.
Plant J., 89, 2017
4KEK
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BU of 4kek by Molmil
Crystal structure of mouse Ryanodine Receptor 2 (1-217) disease mutant R176Q
Descriptor: Ryanodine receptor 2, SULFATE ION
Authors:Kimlicka, L, Van Petegem, F.
Deposit date:2013-04-25
Release date:2013-09-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.146 Å)
Cite:Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic alpha-Helix That Transitions to a beta-Strand in a Mutant Linked with a Heritable Cardiomyopathy.
J.Mol.Biol., 425, 2013
5DZE
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BU of 5dze by Molmil
Crystal Structure of the catalytic nucleophile mutant of VvEG16 in complex with cellotetraose
Descriptor: beta-D-glucopyranose, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose, endo-glucanase
Authors:McGregor, N.G.S, Tung, C.C, Van Petegem, F, Brumer, H.
Deposit date:2015-09-25
Release date:2016-09-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Crystallographic insight into the evolutionary origins of xyloglucan endotransglycosylases and endohydrolases.
Plant J., 89, 2017
4KEJ
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BU of 4kej by Molmil
Crystal structure of mouse Ryanodine Receptor 2 (1-217) disease mutant R169Q
Descriptor: Ryanodine receptor 2
Authors:Kimlicka, L, Van Petegem, F.
Deposit date:2013-04-25
Release date:2013-09-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.553 Å)
Cite:Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic alpha-Helix That Transitions to a beta-Strand in a Mutant Linked with a Heritable Cardiomyopathy.
J.Mol.Biol., 425, 2013
4L4I
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BU of 4l4i by Molmil
Crystal structure of mouse Ryanodine Receptor isoform 2 (RyR2) 1-547 disease mutant R420Q
Descriptor: GLYCEROL, Ryanodine receptor 2
Authors:Kimlicka, L, Van Petegem, F.
Deposit date:2013-06-07
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of ryanodine receptor disease mutant
To be Published
4L4H
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BU of 4l4h by Molmil
Crystal structure of mouse Ryanodine Receptor isoform 2 (RyR2) 1-547
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Ryanodine receptor 2, ...
Authors:Kimlicka, L, Tung, C.C, Van Petegem, F.
Deposit date:2013-06-07
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a ryanodine receptor domain
To be Published
5DZF
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BU of 5dzf by Molmil
Crystal Structure of the catalytic nucleophile mutant of VvEG16 in complex with a mixed-linkage glucan octasaccharide
Descriptor: SULFATE ION, beta-D-glucopyranose, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ...
Authors:McGregor, N.G.S, Tung, C.C, Van Petegem, F, Brumer, H.
Deposit date:2015-09-25
Release date:2016-09-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystallographic insight into the evolutionary origins of xyloglucan endotransglycosylases and endohydrolases.
Plant J., 89, 2017
6U3A
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BU of 6u3a by Molmil
1.65 Angstrom crystal structure of the N97S Ca-CaM:CaV1.2 IQ domain complex
Descriptor: CALCIUM ION, Calmodulin-1, SODIUM ION, ...
Authors:Wang, K, Van Petegem, F.
Deposit date:2019-08-21
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca2+binding and cause misfolding.
J. Physiol. (Lond.), 598, 2020
6U39
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BU of 6u39 by Molmil
2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex
Descriptor: CALCIUM ION, Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C
Authors:Wang, K, Van Petegem, F.
Deposit date:2019-08-21
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca2+binding and cause misfolding.
J. Physiol. (Lond.), 598, 2020
6E60
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BU of 6e60 by Molmil
Bacteroides ovatus mixed-linkage glucan utilization locus (MLGUL) SGBP-A
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, mixed-linkage glucan utilization locus (MLGUL) SGBP-B
Authors:Tamura, K, Gardill, B.R, Brumer, H, Van Petegem, F.
Deposit date:2018-07-23
Release date:2019-05-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Surface glycan-binding proteins are essential for cereal beta-glucan utilization by the human gut symbiont Bacteroides ovatus.
Cell.Mol.Life Sci., 76, 2019
6U3B
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BU of 6u3b by Molmil
1.7 Angstrom crystal structure of the Q135P Ca-CaM:CaV1.2 IQ domain complex
Descriptor: CALCIUM ION, Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C
Authors:Wang, K, Van Petegem, F.
Deposit date:2019-08-21
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca2+binding and cause misfolding.
J. Physiol. (Lond.), 598, 2020
6VHO
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BU of 6vho by Molmil
Glycoside hydrolase family 16 endo-glucanase from Bacteroides ovatus in complex with G4G4G3G-NHCOCH2Br
Descriptor: Glycosyl hydrolase family 16, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-3)-N-acetyl-beta-D-glucopyranosylamine
Authors:Tamura, K, Brumer, H, van Petegem, F.
Deposit date:2020-01-10
Release date:2021-01-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.148 Å)
Cite:Orthogonal Active-Site Labels for Mixed-Linkage endo-beta-Glucanases.
Acs Chem.Biol., 16, 2021
6UY7
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BU of 6uy7 by Molmil
Crystal structure of the STAC3 tandem SH3 domains - P269R
Descriptor: 1,2-ETHANEDIOL, SH3 and cysteine-rich domain-containing protein 3
Authors:Rufenach, B, Van Petegem, F.
Deposit date:2019-11-12
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling.
Structure, 28, 2020
6UY9
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BU of 6uy9 by Molmil
Crystal structure of the STAC3 tandem SH3 domains - P269R, W284S
Descriptor: 1,2-ETHANEDIOL, SH3 and cysteine-rich domain-containing protein 3, SODIUM ION
Authors:Rufenach, B, Van Petegem, F.
Deposit date:2019-11-12
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling.
Structure, 28, 2020
6UY8
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BU of 6uy8 by Molmil
Crystal structure of the STAC3 tandem SH3 domains - P269R, K329N
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, SH3 and cysteine-rich domain-containing protein 3
Authors:Rufenach, B, Van Petegem, F.
Deposit date:2019-11-12
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.649 Å)
Cite:Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling.
Structure, 28, 2020
6W1N
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BU of 6w1n by Molmil
Pig Ryanodine Receptor (WT) in 5mM EGTA condition
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine Receptor, ZINC ION
Authors:Woll, K.W, Haji-Ghassemi, O, Van Petegem, F.
Deposit date:2020-03-04
Release date:2021-01-06
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
Nat Commun, 12, 2021
6X34
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BU of 6x34 by Molmil
Pig R615C RyR1 EGTA (all classes, open)
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine Receptor, ZINC ION
Authors:Woll, K.W, Haji-Ghassemi, O, Van Petegem, F.
Deposit date:2020-05-21
Release date:2021-01-13
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
Nat Commun, 12, 2021

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數據於2024-06-12公開中

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