5KHG

HCN2 CNBD in complex with cytidine-3', 5'-cyclic monophosphate (cCMP)

Summary for 5KHG

Entry DOI	10.2210/pdb5khg/pdb
Related	5KHH 5KHI 5KHJ 5KHK
Descriptor	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, 4-amino-1-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1H)-one (3 entities in total)
Functional Keywords	protein-ligand complex, cycilc nucleotide binding domain, ion transport, transport protein
Biological source	Mus musculus (Mouse)
Cellular location	Cell membrane ; Multi-pass membrane protein : O88703
Total number of polymer chains	1
Total formula weight	24188.51
Authors	Ng, L.C.T.,Putrenko, I.,Baronas, V.,Van Petegem, F.,Accili, E.A. (deposition date: 2016-06-14, release date: 2016-09-14, Last modification date: 2023-09-27)
Primary citation	Ng, L.C.,Putrenko, I.,Baronas, V.,Van Petegem, F.,Accili, E.A. Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening. Structure, 24:1629-1642, 2016 Cited by PubMed: 27568927 DOI: 10.1016/j.str.2016.06.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.241 Å)

Structure validation