3LJ2
| IRE1 complexed with JAK Inhibitor I | Descriptor: | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Serine/threonine-protein kinase/endoribonuclease IRE1 | Authors: | Lee, K.P.K, Sicheri, F. | Deposit date: | 2010-01-25 | Release date: | 2010-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.33 Å) | Cite: | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol.Cell, 38, 2010
|
|
3LJ0
| IRE1 complexed with ADP and Quercetin | Descriptor: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Lee, K.P.K, Sicheri, F. | Deposit date: | 2010-01-25 | Release date: | 2010-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol.Cell, 38, 2010
|
|
2JQZ
| Solution Structure of the C2 domain of human Smurf2 | Descriptor: | E3 ubiquitin-protein ligase SMURF2 | Authors: | Wiesner, S, Ogunjimi, A.A, Wang, H, Rotin, D, Sicheri, F, Wrana, J.L, Forman-Kay, J.D. | Deposit date: | 2007-06-15 | Release date: | 2007-09-11 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain Cell(Cambridge,Mass.), 130, 2007
|
|
3MKS
| Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2 | Descriptor: | 1,1'-binaphthalene-2,2'-dicarboxylic acid, Cell division control protein 4, GLYCEROL, ... | Authors: | Orlicky, S, Sicheri, F, Tyers, M, Tang, X. | Deposit date: | 2010-04-15 | Release date: | 2010-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat.Biotechnol., 28, 2010
|
|
2K8Y
| Solution NMR Structure of Cgi121 from Methanococcus jannaschii. Northeast Structural Genomics Consortium Target MJ0187 | Descriptor: | Uncharacterized protein MJ0187 | Authors: | Rumpel, S, Fares, C, Neculai, D, Arrowsmith, C, Montelione, G.T, Sicheri, F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-09-25 | Release date: | 2008-11-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Mol.Cell, 32, 2008
|
|
3BS5
| Crystal Structure of hCNK2-SAM/dHYP-SAM Complex | Descriptor: | Connector enhancer of kinase suppressor of ras 2, Protein aveugle | Authors: | Rajakulendran, T, Ceccarelli, D.F, Kurinov, I, Sicheri, F. | Deposit date: | 2007-12-22 | Release date: | 2008-02-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
3BQ3
| Crystal structure of S. cerevisiae Dcn1 | Descriptor: | Defective in cullin neddylation protein 1, GLYCEROL | Authors: | Chou, Y.C, Sicheri, F. | Deposit date: | 2007-12-19 | Release date: | 2008-01-29 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation. Mol.Cell, 29, 2008
|
|
6BVA
| |
6BYH
| |
6C16
| |
6CAD
| Crystal structure of RAF kinase domain bound to the inhibitor 2a | Descriptor: | 1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Serine/threonine-protein kinase B-raf | Authors: | Maisonneuve, P, Kurinov, I, Assadieskandar, A, Yu, C, Liu, X, Chen, Y.-C, Prakash, G.K.S, Zhang, C, SIcheri, F. | Deposit date: | 2018-01-30 | Release date: | 2018-02-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Effects of rigidity on the selectivity of protein kinase inhibitors. Eur J Med Chem, 146, 2018
|
|
6CRN
| Structure of the USP15 deubiquitinase domain in complex with a high-affinity first-generation Ubv | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.2, ZINC ION | Authors: | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | Deposit date: | 2018-03-19 | Release date: | 2019-01-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27, 2019
|
|
6BXI
| X-ray crystal structure of NDR1 kinase domain | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase 38 | Authors: | Xiong, S, Sicheri, F. | Deposit date: | 2017-12-18 | Release date: | 2018-08-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Structure, 26, 2018
|
|
6CPM
| Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | Authors: | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | Deposit date: | 2018-03-13 | Release date: | 2019-01-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.011 Å) | Cite: | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27, 2019
|
|
3BS7
| |
5TWH
| |
5TWF
| |
5VYK
| Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1 | Descriptor: | Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf, GLYCEROL | Authors: | Maisonneuve, P, Kurinov, I, Marullo, S.A, Lavoie, H, Thevakumaran, N, Sahmi, M, Jin, T, Therrien, M, SIcheri, F. | Deposit date: | 2017-05-25 | Release date: | 2018-02-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.749 Å) | Cite: | MEK drives BRAF activation through allosteric control of KSR proteins. Nature, 554, 2018
|
|
5TWG
| |
4KSJ
| |
4KSK
| |
4KSL
| |
4I6L
| |
4JVG
| B-Raf Kinase in Complex with Birb796 | Descriptor: | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, Serine/threonine-protein kinase B-raf | Authors: | Lavoie, H, Thevakumaran, N, Gavory, G, Li, J, Padeganeh, A, Guiral, S, Duchaine, J, Mao, D.Y.L, Bouvier, M, Sicheri, F, Therrien, M. | Deposit date: | 2013-03-25 | Release date: | 2013-05-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.09 Å) | Cite: | Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nat.Chem.Biol., 9, 2013
|
|
8T7T
| |