Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2

Summary for 3MKS

DescriptorSuppressor of kinetochore protein 1, Cell division control protein 4, SULFATE ION, ... (6 entities in total)
Functional Keywordsubiquitin ligase, protein binding, small molecule complex, ligase/cell cycle, ligase-cell cycle complex
Biological sourceSaccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast)
Total number of polymer chains4
Total molecular weight146224.45
Orlicky, S.,Sicheri, F.,Tyers, M.,Tang, X. (deposition date: 2010-04-15, release date: 2010-07-21, Last modification date: 2019-07-17)
Primary citation
Orlicky, S.,Tang, X.,Neduva, V.,Elowe, N.,Brown, E.D.,Sicheri, F.,Tyers, M.
An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase.
Nat.Biotechnol., 28:733-737, 2010
PubMed: 20581844 (PDB entries with the same primary citation)
DOI: 10.1038/nbt.1646
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26115 1.4% 9.9% 0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-23