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5DRI
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BU of 5dri by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-hydroxy-4-(1H-indol-5-yl)-4-oxobut-2-enoic acid inhibitor
Descriptor: (2Z)-2-hydroxy-4-(1H-indol-5-yl)-4-oxobut-2-enoic acid, MAGNESIUM ION, Malate synthase G
Authors:Krieger, I.V, Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-09-15
Release date:2016-09-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5DX7
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BU of 5dx7 by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 5-(5-chlorothiophen-2-yl)isoxazole-3-carboxylic acid
Descriptor: 5-(5-chlorothiophen-2-yl)-1,2-oxazole-3-carboxylic acid, MAGNESIUM ION, Malate synthase G
Authors:Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-09-23
Release date:2016-10-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5ECV
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BU of 5ecv by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-hydroxy-4-(4-methyl-1H-indol-5-yl)-4-oxobut-2-enoic acid
Descriptor: (~{Z})-4-(4-methyl-1~{H}-indol-5-yl)-2-oxidanyl-4-oxidanylidene-but-2-enoic acid, MAGNESIUM ION, Malate synthase G
Authors:Krieger, I.V, Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-10-20
Release date:2016-10-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.085 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5E9X
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BU of 5e9x by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-chloro-6H-thieno[2,3-b]pyrrole-5-carboxylic acid
Descriptor: 2-chloranyl-6~{H}-thieno[2,3-b]pyrrole-5-carboxylic acid, MAGNESIUM ION, Malate synthase G
Authors:Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-10-15
Release date:2016-10-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.943 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5DRC
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BU of 5drc by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-hydroxy-4-(1H-indol-3-yl)-4-oxobut-2-enoic acid
Descriptor: (2Z)-2-hydroxy-4-(1H-indol-3-yl)-4-oxobut-2-enoic acid, MAGNESIUM ION, Malate synthase G
Authors:Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-09-15
Release date:2016-09-28
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5CC5
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BU of 5cc5 by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 1H-indole-3-carboxylic acid
Descriptor: 1H-INDOLE-3-CARBOXYLIC ACID, GLYOXYLIC ACID, MAGNESIUM ION, ...
Authors:Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-07-01
Release date:2016-08-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs
To Be Published
5CC6
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BU of 5cc6 by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 1H-indole-5-carboxylic acid
Descriptor: 1H-indole-5-carboxylic acid, MAGNESIUM ION, Malate synthase G
Authors:Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-07-01
Release date:2016-08-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs
To Be Published
5CC3
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BU of 5cc3 by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 6-bromo-1H-indole-2-carboxylic acid
Descriptor: 6-bromanyl-1H-indole-2-carboxylic acid, MAGNESIUM ION, Malate synthase G
Authors:Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-07-01
Release date:2016-08-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs
To Be Published
5CC7
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BU of 5cc7 by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 1H-indole-6-carboxylic acid
Descriptor: 1H-indole-6-carboxylic acid, MAGNESIUM ION, Malate synthase G
Authors:Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-07-01
Release date:2016-08-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs
To Be Published
8P0V
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BU of 8p0v by Molmil
Structure of the human Commander complex coiled coils, DENND10 and partial Retriever subcomplex
Descriptor: Coiled-coil domain-containing protein 22, Coiled-coil domain-containing protein 93, DENN domain-containing protein 10, ...
Authors:Kumpula, E.P, Laulumaa, S, Huiskonen, J.T.
Deposit date:2023-05-10
Release date:2024-03-20
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Structure and interactions of the endogenous human Commander complex.
Nat.Struct.Mol.Biol., 31, 2024
8PJ4
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BU of 8pj4 by Molmil
Structure of human 48S translation initiation complex after eIF5 release (48S-4)
Descriptor: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Petrychenko, V, Yi, S.-H, Liedtke, D, Peng, B.Z, Rodnina, M.V, Fischer, N.
Deposit date:2023-06-22
Release date:2024-08-14
Last modified:2024-10-02
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for translational control by the human 48S initiation complex.
Nat.Struct.Mol.Biol., 2024
6ZHX
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BU of 6zhx by Molmil
Cryo-EM structure of the regulatory linker of ALC1 bound to the nucleosome's acidic patch: nucleosome class.
Descriptor: Chromodomain-helicase-DNA-binding protein 1-like, DNA (145-MER) Widom 601 sequence, Histone H2A type 1, ...
Authors:Bacic, L, Gaullier, G, Croll, T.I, Deindl, S.
Deposit date:2020-06-24
Release date:2020-12-23
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
Cell Rep, 33, 2020
8PJ3
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BU of 8pj3 by Molmil
Structure of human 48S translation initiation complex upon transfer of initiator tRNA to eIF5B (48S-3)
Descriptor: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Petrychenko, V, Yi, S.-H, Liedtke, D, Peng, B.Z, Rodnina, M.V, Fischer, N.
Deposit date:2023-06-22
Release date:2024-08-14
Last modified:2024-10-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for translational control by the human 48S initiation complex.
Nat.Struct.Mol.Biol., 2024
7KQE
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BU of 7kqe by Molmil
SARS-CoV-2 spike glycoprotein:Fab 3D11 complex
Descriptor: Fab 3D11 heavy chain, Fab 3D11 light chain, Spike glycoprotein
Authors:Asarnow, D, Charles, C, Cheng, Y.
Deposit date:2020-11-15
Release date:2021-05-26
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.
Cell, 184, 2021
7Z2A
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BU of 7z2a by Molmil
P. berghei kinesin-8B motor domain in no nucleotide state bound to tubulin dimer
Descriptor: Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ...
Authors:Liu, T, Shilliday, F, Cook, A.D, Moores, C.A.
Deposit date:2022-02-26
Release date:2022-10-19
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
7Z2B
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BU of 7z2b by Molmil
P. berghei kinesin-8B motor domain in AMPPNP state bound to tubulin dimer
Descriptor: Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ...
Authors:Liu, T, Shilliday, F, Cook, A.D, Moores, C.A.
Deposit date:2022-02-26
Release date:2022-11-16
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
8AXX
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BU of 8axx by Molmil
Expanded Coxsackievirus A9 after treatment with endosomal ionic buffer
Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Domanska, A, Plavec, Z, Ruokolainen, V, Loflund, B, Marjomaki, V.S, Butcher, S.J.
Deposit date:2022-09-01
Release date:2022-10-19
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural Studies Reveal that Endosomal Cations Promote Formation of Infectious Coxsackievirus A9 A-Particles, Facilitating RNA and VP4 Release.
J.Virol., 96, 2022
7Z2C
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BU of 7z2c by Molmil
P. falciparum kinesin-8B motor domain in no nucleotide bound to tubulin dimer
Descriptor: Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ...
Authors:Liu, T, Shilliday, F, Cook, A.D, Moores, C.A.
Deposit date:2022-02-26
Release date:2022-10-19
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
7S1G
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BU of 7s1g by Molmil
wild-type Escherichia coli stalled ribosome with antibiotic linezolid
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D.
Deposit date:2021-09-02
Release date:2021-11-17
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.48 Å)
Cite:Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics.
Nat.Struct.Mol.Biol., 29, 2022
7S1H
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BU of 7s1h by Molmil
Wild-type Escherichia coli ribosome with antibiotic linezolid
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D.
Deposit date:2021-09-02
Release date:2021-11-17
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.35 Å)
Cite:Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics.
Nat.Struct.Mol.Biol., 29, 2022
7RU6
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BU of 7ru6 by Molmil
Cryo-EM structure of the HIV-1 restriction factor human SERINC3
Descriptor: Serine incorporator 3, SiA
Authors:Purdy, M.D, Leonhardt, S.A, Yeager, M.
Deposit date:2021-08-16
Release date:2022-08-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.
Nat Commun, 14, 2023
7RUG
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BU of 7rug by Molmil
Human SERINC3-DeltaICL4
Descriptor: Serine incorporator 3, SiA
Authors:Purdy, M.D, Leonhardt, S.A, Yeager, M.
Deposit date:2021-08-17
Release date:2022-08-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.
Nat Commun, 14, 2023
8GH8
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BU of 8gh8 by Molmil
RuvA Holliday junction DNA complex
Descriptor: DNA (34-MER), Holliday junction branch migration complex subunit RuvA
Authors:Rish, A.D, Fu, T.
Deposit date:2023-03-09
Release date:2023-05-10
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:RuvA Holliday junction DNA complex
To Be Published
8G9B
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BU of 8g9b by Molmil
Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ...
Authors:O'Neill, A.G, Kollman, J.M.
Deposit date:2023-02-21
Release date:2023-04-19
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.
J.Biol.Chem., 299, 2023
8G8F
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BU of 8g8f by Molmil
Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; extended filament segment reconstruction
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, ...
Authors:O'Neill, A.G, Kollman, J.M.
Deposit date:2023-02-17
Release date:2023-04-19
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.
J.Biol.Chem., 299, 2023

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數據於2024-10-30公開中

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