5ECV

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-hydroxy-4-(4-methyl-1H-indol-5-yl)-4-oxobut-2-enoic acid

Summary for 5ECV

Entry DOI	10.2210/pdb5ecv/pdb
Descriptor	Malate synthase G, MAGNESIUM ION, (~{Z})-4-(4-methyl-1~{H}-indol-5-yl)-2-oxidanyl-4-oxidanylidene-but-2-enoic acid, ... (4 entities in total)
Functional Keywords	transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm : P9WK17
Total number of polymer chains	1
Total formula weight	80726.27
Authors	Krieger, I.V.,Huang, H.-L.,Sacchettini, J.C. (deposition date: 2015-10-20, release date: 2016-10-26, Last modification date: 2023-09-27)
Primary citation	Huang, H.L.,Krieger, I.V.,Parai, M.K.,Gawandi, V.B.,Sacchettini, J.C. Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291:27421-27432, 2016 Cited by PubMed: 27738104 DOI: 10.1074/jbc.M116.750877 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.085 Å)

Structure validation