7RU6

Cryo-EM structure of the HIV-1 restriction factor human SERINC3

Summary for 7RU6

• Entry DOI: 10.2210/pdb7ru6/pdb
• EMDB information: 24698 24705
• Descriptor: Serine incorporator 3, SiA (2 entities in total)
• Functional Keywords: flippase, viral restriction, hiv-1, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 80679.14

Authors

Purdy, M.D.,Leonhardt, S.A.,Yeager, M. (deposition date: 2021-08-16, release date: 2022-08-24, Last modification date: 2023-09-06)

• Primary citation: Leonhardt, S.A.,Purdy, M.D.,Grover, J.R.,Yang, Z.,Poulos, S.,McIntire, W.E.,Tatham, E.A.,Erramilli, S.K.,Nosol, K.,Lai, K.K.,Ding, S.,Lu, M.,Uchil, P.D.,Finzi, A.,Rein, A.,Kossiakoff, A.A.,Mothes, W.,Yeager, M.; Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.; Nat Commun, 14:4368-4368, 2023; PubMed: 37474505; DOI: 10.1038/s41467-023-39262-2

Experimental method

ELECTRON MICROSCOPY (4.4 Å)