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Crystal structure of arabidopsis thaliana legumain isoform gamma in two-chain activation state
Descriptor:	CITRIC ACID, SULFATE ION, Vacuolar-processing enzyme gamma-isozyme
Authors:	Zauner, F.B, Dall, E, Brandstetter, H.
Deposit date:	2017-03-24
Release date:	2018-02-28
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation. Plant Cell, 30, 2018

5O7E

Crystal structure of the peptidase domain of collagenase H from Clostridium histolyticum in complex with N-aryl mercaptoacetamide-based inhibitor
Descriptor:	CALCIUM ION, ColH protein, ZINC ION, ...
Authors:	Schoenauer, E, Brandstetter, H.
Deposit date:	2017-06-08
Release date:	2018-01-31
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.87 Å)
Cite:	Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases. J. Am. Chem. Soc., 139, 2017

5NZC

A disulfide switch determines proteolytic resistance in the birch pollen allergen Bet v 2
Descriptor:	Profilin-2
Authors:	Soh, W.T, Brandstetter, H.
Deposit date:	2017-05-12
Release date:	2017-10-25
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.999 Å)
Cite:	Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S. Int J Mol Sci, 18, 2017

5NZB

A disulfide switch determines proteolytic resistance in the birch pollen allergen Bet v 2
Descriptor:	Profilin-2
Authors:	Soh, W.T, Brandstetter, H.
Deposit date:	2017-05-12
Release date:	2017-10-25
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.695 Å)
Cite:	Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S. Int J Mol Sci, 18, 2017

5OBT

Fully activated A. thaliana legumain isoform gamma in complex with Ac-YVAD-CMK
Descriptor:	Ac-YVAD-CMK, Vacuolar-processing enzyme gamma-isozyme
Authors:	Zauner, B.F, Dall, E, Brandstetter, H.
Deposit date:	2017-06-29
Release date:	2018-04-11
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Structural analyses ofArabidopsis thalianalegumain gamma reveal differential recognition and processing of proteolysis and ligation substrates. J. Biol. Chem., 293, 2018

2Y6I

Crystal Structure of Collagenase G from Clostridium histolyticum in complex with Isoamylphosphonyl-Gly-Pro-Ala at 3.25 Angstrom Resolution
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CITRATE ANION, COLLAGENASE, ...
Authors:	Eckhard, U, Brandstetter, H.
Deposit date:	2011-01-21
Release date:	2011-09-28
Last modified:	2015-09-16
Method:	X-RAY DIFFRACTION (3.25 Å)
Cite:	Structure of Collagenase G Reveals a Chew-and -Digest Mechanism of Bacterial Collagenolysis Nat.Struct.Mol.Biol., 18, 2011

2Y3U

Crystal structure of apo collagenase G from Clostridium histolyticum at 2.55 Angstrom resolution
Descriptor:	CITRATE ANION, COLLAGENASE, DI(HYDROXYETHYL)ETHER, ...
Authors:	Eckhard, U, Brandstetter, H.
Deposit date:	2010-12-26
Release date:	2011-09-28
Last modified:	2011-10-19
Method:	X-RAY DIFFRACTION (2.55 Å)
Cite:	Structure of Collagenase G Reveals a Chew-and -Digest Mechanism of Bacterial Collagenolysis Nat.Struct.Mol.Biol., 18, 2011

2Y50

Crystal Structure of Collagenase G from Clostridium histolyticum at 2. 80 Angstrom Resolution
Descriptor:	CITRATE ANION, COLLAGENASE, HEXAETHYLENE GLYCOL, ...
Authors:	Eckhard, U, Brandstetter, H.
Deposit date:	2011-01-11
Release date:	2011-09-28
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Structure of Collagenase G Reveals a Chew-and -Digest Mechanism of Bacterial Collagenolysis Nat.Struct.Mol.Biol., 18, 2011

4AWA

Crystal structure of active legumain in complex with YVAD-CMK at pH 5.0
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, LEGUMAIN, SULFATE ION, ...
Authors:	Dall, E, Brandstetter, H.
Deposit date:	2012-06-01
Release date:	2013-06-26
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Mechanistic and Structural Studies on Legumain Explain its Zymogenicity, Distinct Activation Pathways, and Regulation Proc.Natl.Acad.Sci.USA, 110, 2013

4B9R

Crystal structure of the Major Birch Pollen Allergen Bet v 1.0101 (isoform a) nitrated in vitro with tetranitromethan.
Descriptor:	MAJOR POLLEN ALLERGEN BET V 1-A, SULFATE ION
Authors:	Kofler, S, Ackaert, C, Brandstetter, H.
Deposit date:	2012-09-06
Release date:	2013-10-16
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.76 Å)
Cite:	The Impact of Nitration on the Structure and Immunogenicity of the Major Birch Pollen Allergen Bet V 1.0101. Plos One, 9, 2014

4AWB

Crystal structure of active legumain in complex with AAN-CMK
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, LEGUMAIN, MERCURY (II) ION, ...
Authors:	Dall, E, Brandstetter, H.
Deposit date:	2012-06-01
Release date:	2013-06-26
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Mechanistic and Structural Studies on Legumain Explain its Zymogenicity, Distinct Activation Pathways, and Regulation Proc.Natl.Acad.Sci.USA, 110, 2013

4BKC

Crystal Structure of a unusually linked dimeric variant of Bet v 1
Descriptor:	MAJOR POLLEN ALLERGEN BET V 1-A
Authors:	Kofler, S.G, Brandstetter, H.
Deposit date:	2013-04-23
Release date:	2013-11-27
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.73 Å)
Cite:	Stabilization of the Dimeric Birch Pollen Allergen Bet V 1 Impacts its Immunological Properties J.Biol.Chem., 289, 2014

4BK7

Crystal Structure of a variant of the Major Birch Pollen Allergen Bet v 1
Descriptor:	(4S)-2-METHYL-2,4-PENTANEDIOL, MAJOR POLLEN ALLERGEN BET V 1-A, SODIUM ION, ...
Authors:	Kofler, S, Brandstetter, H.
Deposit date:	2013-04-22
Release date:	2013-11-27
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.14 Å)
Cite:	Stabilization of the Dimeric Birch Pollen Allergen Bet V 1 Impacts its Immunological Properties J.Biol.Chem., 289, 2014

4BK6

Crystal Structure of a dimeric variant of Bet v 1
Descriptor:	MAJOR POLLEN ALLERGEN BET V 1-A
Authors:	Kofler, S.G, Brandstetter, H.
Deposit date:	2013-04-22
Release date:	2013-11-27
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.63 Å)
Cite:	Stabilization of the Dimeric Birch Pollen Allergen Bet V 1 Impacts its Immunological Properties J.Biol.Chem., 289, 2014

4BKD

Crystal Structure of an unusually linked dimeric variant of Bet v 1 (b)
Descriptor:	MAJOR POLLEN ALLERGEN BET V 1-A
Authors:	Kofler, S.G, Brandstetter, H.
Deposit date:	2013-04-23
Release date:	2013-11-27
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.17 Å)
Cite:	Stabilization of the dimeric birch pollen allergen Bet v 1 impacts its immunological properties. J.Biol.Chem., 289, 2014

4BTZ

Crystal Structure of peroxinitrite treated Major Birch Pollen Allergen Bet v 1.0101 (isoform a)
Descriptor:	(4S)-2-METHYL-2,4-PENTANEDIOL, MAJOR POLLEN ALLERGEN BET V 1-A
Authors:	Kofler, S.G, Ackaert, C, Brandstetter, H.
Deposit date:	2013-06-19
Release date:	2014-07-02
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.47 Å)
Cite:	The Crystal Structure of the Major Birch Pollen Allergen Bet V 1 After Nitration with Peroxinitrite To be Published

1JH1

Crystal Structure of MMP-8 complexed with a 6H-1,3,4-thiadiazine derived inhibitor
Descriptor:	BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE, CALCIUM ION, Matrix Metalloproteinase 8, ...
Authors:	Schroder, J, Henke, A, Wenzel, H, Brandstetter, H, Stammler, H.G, Stammler, A, Pfeiffer, W.D, Tschesche, H.
Deposit date:	2001-06-27
Release date:	2001-12-27
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold. J.Med.Chem., 44, 2001

1J2Q

20S proteasome in complex with calpain-Inhibitor I from archaeoglobus fulgidus
Descriptor:	2-ACETYLAMINO-4-METHYL-PENTANOIC ACID [1-(1-FORMYL-PENTYLCARBAMOYL)-3-METHYL-BUTYL]-AMIDE, Proteasome alpha subunit, Proteasome beta subunit
Authors:	Groll, M, Brandstetter, H, Bartunik, H, Bourenkow, G, Huber, R.
Deposit date:	2003-01-08
Release date:	2003-03-18
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.83 Å)
Cite:	Investigations on the Maturation and Regulation of Archaebacterial Proteasomes J.MOL.BIOL., 327, 2003

1ITV

Dimeric form of the haemopexin domain of MMP9
Descriptor:	MMP9, SULFATE ION
Authors:	Cha, H, Kopetzki, E, Huber, R, Lanzendoerfer, M, Brandstetter, H.
Deposit date:	2002-02-11
Release date:	2002-09-04
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Structural basis of the adaptive molecular recognition by MMP9. J.Mol.Biol., 320, 2002

1J2P

alpha-ring from the proteasome from archaeoglobus fulgidus
Descriptor:	Proteasome alpha subunit
Authors:	Groll, M, Brandstetter, H, Bartunik, H, Bourenkow, G, Huber, R.
Deposit date:	2003-01-08
Release date:	2003-03-18
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Investigations on the Maturation and Regulation of Archaebacterial Proteasomes J.MOL.BIOL., 327, 2003

1RFN

HUMAN COAGULATION FACTOR IXA IN COMPLEX WITH P-AMINO BENZAMIDINE
Descriptor:	CALCIUM ION, P-AMINO BENZAMIDINE, PROTEIN (COAGULATION FACTOR IX), ...
Authors:	Hopfner, K.-P, Lang, A, Karcher, A, Sichler, K, Kopetzki, E, Brandstetter, H, Huber, R, Bode, W, Engh, R.A.
Deposit date:	1999-04-19
Release date:	1999-09-01
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding. Structure Fold.Des., 7, 1999

1S0P

Structure of the N-Terminal Domain of the Adenylyl Cyclase-Associated Protein (CAP) from Dictyostelium discoideum.
Descriptor:	Adenylyl cyclase-associated protein, MAGNESIUM ION
Authors:	Ksiazek, D, Brandstetter, H, Israel, L, Bourenkov, G.P, Katchalova, G, Janssen, K.P, Bartunik, H.D, Noegel, A.A, Schleicher, M, Holak, T.A.
Deposit date:	2004-01-01
Release date:	2004-01-27
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	STRUCTURE OF THE N-TERMINAL DOMAIN OF THE ADENYLYL CYCLASE-ASSOCIATED PROTEIN (CAP) FROM DICTYOSTELIUM DISCOIDEUM Structure, 11, 2003

1ORW

Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with a Peptidomimetic Inhibitor
Descriptor:	(2S)-PYRROLIDIN-2-YLMETHYLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Engel, M, Hoffmann, T, Wagner, L, Wermann, M, Heiser, U, Kiefersauer, R, Huber, R, Bode, W, Demuth, H.U, Brandstetter, H.
Deposit date:	2003-03-16
Release date:	2003-05-06
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.84 Å)
Cite:	The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals its Functional Regulation and Enzymatic Mechanism Proc.Natl.Acad.Sci.USA, 100, 2003

1N6E

tricorn protease in complex with a tridecapeptide chloromethyl ketone derivative
Descriptor:	DQTQKAAAELTFF, Tricorn protease
Authors:	Kim, J.-S, Groll, M, Huber, R, Brandstetter, H.
Deposit date:	2002-11-10
Release date:	2002-12-30
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Navigation Inside a Protease: Substrate Selection and Product Exit in the Tricorn Protease from Thermoplasma acidophilum J.Mol.Biol., 324, 2002

1N6F

tricorn protease in complex with Z-Phe-diketo-Arg-Glu-Phe
Descriptor:	4-[2-(3-BENZYLOXYCARBONYLAMINO-4-CYCLOHEXYL-1-HYDROXY-2-OXO-BUTYLAMINO)-5-GUANIDINO-PENTANOYLAMINO]-4-(1-CARBOXY-2-CYCLOHEXYL-ETHYLCARBAMOYL)-BUTYRIC ACID, tricorn protease
Authors:	Kim, J.-S, Groll, M, Huber, R, Brandstetter, H.
Deposit date:	2002-11-10
Release date:	2002-12-30
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Navigation Inside a Protease: Substrate Selection and Product Exit in the Tricorn Protease from Thermoplasma acidophilum J.Mol.Biol., 324, 2002

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