4AWA
Crystal structure of active legumain in complex with YVAD-CMK at pH 5.0
Summary for 4AWA
| Entry DOI | 10.2210/pdb4awa/pdb |
| Related | 4AW9 4AWB 4FGU |
| Related PRD ID | PRD_002086 |
| Descriptor | LEGUMAIN, YVAD-CMK, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | hydrolase-hydrolase inhibitor complex, cysteine protease, lysosomal, aep, substrate specificity, mhcii, antigen processing, cancer, hydrolase/hydrolase inhibitor |
| Biological source | HOMO SAPIENS (HUMAN) More |
| Total number of polymer chains | 2 |
| Total formula weight | 33653.95 |
| Authors | Dall, E.,Brandstetter, H. (deposition date: 2012-06-01, release date: 2013-06-26, Last modification date: 2023-12-20) |
| Primary citation | Dall, E.,Brandstetter, H. Mechanistic and Structural Studies on Legumain Explain its Zymogenicity, Distinct Activation Pathways, and Regulation Proc.Natl.Acad.Sci.USA, 110:10940-, 2013 Cited by PubMed: 23776206DOI: 10.1073/PNAS.1300686110 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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