1ORW

Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with a Peptidomimetic Inhibitor

Summary for 1ORW

• Entry DOI: 10.2210/pdb1orw/pdb
• Related: 1ORV
• Descriptor: dipeptidyl peptidase IV, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: serine protease, oxyanion hole, substrate channeling, drug design, diabetes mellitus, hydrolase
• Biological source: Sus scrofa (pig)
• Total number of polymer chains: 4
• Total formula weight: 347128.38

Authors

Engel, M.,Hoffmann, T.,Wagner, L.,Wermann, M.,Heiser, U.,Kiefersauer, R.,Huber, R.,Bode, W.,Demuth, H.U.,Brandstetter, H. (deposition date: 2003-03-16, release date: 2003-05-06, Last modification date: 2020-07-29)

• Primary citation: Engel, M.,Hoffmann, T.,Wagner, L.,Wermann, M.,Heiser, U.,Kiefersauer, R.,Huber, R.,Bode, W.,Demuth, H.U.,Brandstetter, H.; The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals its Functional Regulation and Enzymatic Mechanism; Proc.Natl.Acad.Sci.USA, 100:5063-5068, 2003; PubMed: 12690074; DOI: 10.1073/pnas.0230620100

Experimental method

X-RAY DIFFRACTION (2.84 Å)