3U46
| CH04H/CH02L P212121 | Descriptor: | CH02 Light chain Fab, CH04 Heavy chain Fab | Authors: | Louder, R, Pancera, M, McLellan, J.S, Kwong, P.D. | Deposit date: | 2011-10-07 | Release date: | 2011-11-30 | Last modified: | 2011-12-21 | Method: | X-RAY DIFFRACTION (2.906 Å) | Cite: | Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature, 480, 2011
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4JM4
| Crystal Structure of PGT 135 Fab | Descriptor: | PGT 135 Heavy Chain, PGT 135 Light Chain | Authors: | Kong, L, Wilson, I.A. | Deposit date: | 2013-03-13 | Release date: | 2013-05-29 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat.Struct.Mol.Biol., 20, 2013
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3TYG
| Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with a glycosylated engineered gp120 outer domain with miniV3 (eODmV3) | Descriptor: | Envelope glycoprotein gp160, PGT128 heavy chain, Ig gamma-1 chain C region, ... | Authors: | Pejchal, R, Huang, P.S, Schief, W.R, Stanfield, R.L, Wilson, I.A. | Deposit date: | 2011-09-25 | Release date: | 2011-10-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science, 334, 2011
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4JPJ
| Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6 | Authors: | Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A. | Deposit date: | 2013-03-19 | Release date: | 2013-04-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013
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3U4E
| Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain CAP45 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PG9 Heavy Chain, PG9 Light Chain, ... | Authors: | Gorman, J, McLellan, J, Pancera, M, Kwong, P.D. | Deposit date: | 2011-10-07 | Release date: | 2011-11-30 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.185 Å) | Cite: | Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature, 480, 2011
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3U2S
| Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain ZM109 | Descriptor: | (R,R)-2,3-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | McLellan, J.S, Pancera, M, Kwong, P.D. | Deposit date: | 2011-10-04 | Release date: | 2011-11-30 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.797 Å) | Cite: | Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature, 480, 2011
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4JPI
| Crystal structure of a putative VRC01 germline precursor Fab | Descriptor: | GLYCEROL, Putative VRC01 germline Fab heavy chain, Putative VRC01 germline Fab light chain | Authors: | Julien, J.-P, Diwanji, D.C, Jardine, J, Schief, W.R, Wilson, I.A. | Deposit date: | 2013-03-19 | Release date: | 2013-04-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013
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4JPK
| Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain eOD-GT6 in complex with a putative VRC01 germline precursor Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6, ... | Authors: | Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A. | Deposit date: | 2013-03-19 | Release date: | 2013-04-10 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013
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4KTD
| Fab fragment of HIV vaccine-elicited CD4bs-directed antibody, GE136, from non-human primate | Descriptor: | GE136 Heavy Chain Fab, GE136 Light Chain Fab, GLYCEROL, ... | Authors: | Poulsen, C, Tran, K, Standfield, R, Wyatt, R.T. | Deposit date: | 2013-05-20 | Release date: | 2014-02-05 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign. Proc.Natl.Acad.Sci.USA, 111, 2014
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7LOP
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV05-163 and CR3022 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 Fab heavy chain, CR3022 Fab light chain, ... | Authors: | Yuan, M, Zhu, X, Wilson, I.A. | Deposit date: | 2021-02-10 | Release date: | 2021-03-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.246 Å) | Cite: | Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. Science, 373, 2021
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7LQ7
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV503 and COVA1-16 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COVA1-16 heavy chain, COVA1-16 light chain, ... | Authors: | Yuan, M, Zhu, X, Wilson, I.A. | Deposit date: | 2021-02-13 | Release date: | 2021-09-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern. Sci Transl Med, 13, 2021
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7KKZ
| Crystal structure of mouse anti-HIV potent neutralizing antibody M4H2K1 | Descriptor: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Heavy chain of Fab fragment of mouse monoclonal antibody M4H2K1, ... | Authors: | Kumar, S, Wilson, I.A. | Deposit date: | 2020-10-28 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles. Mbio, 12, 2021
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7KMD
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7KLC
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6AVN
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6AXL
| Crystal structure of Fab317 complex | Descriptor: | Fab317 heavy chain, Fab317 light chains, Peptide ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-NH2 | Authors: | Oyen, D, Wilson, I.A. | Deposit date: | 2017-09-07 | Release date: | 2017-11-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6AXK
| Crystal structure of Fab311 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN, Fab311 heavy chain, ... | Authors: | Oyen, D, Wilson, I.A. | Deposit date: | 2017-09-07 | Release date: | 2017-11-22 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6B0N
| Crystal structure of the cleavage-independent prefusion HIV Env glycoprotein trimer of the clade A BG505 isolate (NFL construct) in complex with Fabs PGT122 and PGV19 at 3.39 A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp140, ... | Authors: | Sarkar, A, Irimia, A, Wilson, I.A. | Deposit date: | 2017-09-14 | Release date: | 2018-05-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer. Nat Commun, 9, 2018
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6CNW
| STRUCTURE OF HUMANIZED SINGLE DOMAIN ANTIBODY SD84 | Descriptor: | ACETATE ION, DI(HYDROXYETHYL)ETHER, humanized antibody SD84h | Authors: | Luo, J, Obmolova, O. | Deposit date: | 2018-03-09 | Release date: | 2018-11-14 | Method: | X-RAY DIFFRACTION (0.92 Å) | Cite: | Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin. Science, 362, 2018
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6CA9
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6CA7
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6CA6
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6CK8
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6CNV
| INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR9114 Fab heavy chain, ... | Authors: | Luo, J, Obmolova, G. | Deposit date: | 2018-03-09 | Release date: | 2018-11-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin. Science, 362, 2018
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6CE0
| Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ... | Authors: | Kumar, S, Sarkar, A, Wilson, I.A. | Deposit date: | 2018-02-09 | Release date: | 2018-12-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.602 Å) | Cite: | HIV-1 vaccine design through minimizing envelope metastability. Sci Adv, 4, 2018
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