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7T1U
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BU of 7t1u by Molmil
Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide
Descriptor: Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION
Authors:Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S.
Deposit date:2021-12-02
Release date:2022-08-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
6ML1
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BU of 6ml1 by Molmil
Structure of the USP15 deubiquitinase domain in complex with an affinity-matured inhibitory Ubv
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S.
Deposit date:2018-09-26
Release date:2019-01-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
7XK2
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BU of 7xk2 by Molmil
Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex
Descriptor: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, Han, G.W, DiBerto, J.F, Wu, L.J, Tong, J.H, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J.
Deposit date:2022-04-19
Release date:2023-02-22
Last modified:2023-12-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into the human niacin receptor HCA2-G i signalling complex.
Nat Commun, 14, 2023
4TZI
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BU of 4tzi by Molmil
Structure of unliganded Lyn SH2 domain
Descriptor: Tyrosine-protein kinase Lyn
Authors:Wybenga-Groot, L.E.
Deposit date:2014-07-10
Release date:2015-01-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity.
Mol.Cell Proteomics, 14, 2015
3V6E
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BU of 3v6e by Molmil
Crystal Structure of USP2 and a mutant form of Ubiquitin
Descriptor: CHLORIDE ION, GLYCEROL, Ubiquitin, ...
Authors:Neculai, M, Ernst, A, Sidhu, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2011-12-19
Release date:2012-12-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
7YF5
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BU of 7yf5 by Molmil
Crystal Structure of the UDPGA Binding Domain of the Human Phase II Metabolizing Enzyme UDP-Glucuronosyltransferase 2B10
Descriptor: SULFATE ION, UDP-glucuronosyltransferase 2B10
Authors:Yin, X.L, Tong, J.S.
Deposit date:2022-07-07
Release date:2023-07-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.527 Å)
Cite:Crystal Structure Determination of Nucleotide-sugar Binding Domain of Human UDP-glucuronosyltransferases 2B10.
Protein Pept.Lett., 30, 2023
7Y3O
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BU of 7y3o by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody BIOLS56
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of BIOLS56, Light chain of BIOLS56, ...
Authors:Rao, X, Gao, F, Wu, Y, Gao, F.
Deposit date:2022-06-11
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 120, 2023
7Y3N
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BU of 7y3n by Molmil
Crystal structure of SARS-CoV receptor binding domain in complex with human antibody BIOLS56
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of BIOLS56, ...
Authors:Rao, X, Chai, Y, Wu, Y, Gao, F.
Deposit date:2022-06-11
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 120, 2023
6CPM
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BU of 6cpm by Molmil
Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ...
Authors:Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S.
Deposit date:2018-03-13
Release date:2019-01-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6CRN
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BU of 6crn by Molmil
Structure of the USP15 deubiquitinase domain in complex with a high-affinity first-generation Ubv
Descriptor: Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.2, ZINC ION
Authors:Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S.
Deposit date:2018-03-19
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
4I6L
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BU of 4i6l by Molmil
Crystal structure of OTUB1 in complex with ubiquitin variant
Descriptor: Ubiquitin, Ubiquitin thioesterase OTUB1
Authors:Juang, Y.C, Sicheri, F.
Deposit date:2012-11-29
Release date:2013-01-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.488 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
5H2C
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BU of 5h2c by Molmil
Crystal structure of Saccharomyces cerevisiae Osh1 ANK - Nvj1
Descriptor: Nucleus-vacuole junction protein 1, Oxysterol-binding protein homolog 1
Authors:Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S.
Deposit date:2016-10-14
Release date:2017-05-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.508 Å)
Cite:Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction
Structure, 25, 2017
5H2D
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BU of 5h2d by Molmil
Crystal structure of Osh1 ORD domain in complex with ergosterol
Descriptor: ERGOSTEROL, KLLA0C04147p, SULFATE ION
Authors:Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S.
Deposit date:2016-10-14
Release date:2017-05-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction
Structure, 25, 2017
5H28
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BU of 5h28 by Molmil
Crystal structure of Osh1 ANK domain from Saccharomyces cerevisia
Descriptor: Oxysterol-binding protein homolog 1
Authors:Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S.
Deposit date:2016-10-14
Release date:2017-05-17
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction
Structure, 25, 2017
5H2A
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BU of 5h2a by Molmil
Crystal structure of Osh1 ANK domain from Kluyveromyces lactis
Descriptor: KLLA0C04147p
Authors:Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S.
Deposit date:2016-10-14
Release date:2017-05-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction
Structure, 25, 2017
5WVR
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BU of 5wvr by Molmil
Crystal structure of Osh1 ORD domain in complex with cholesterol
Descriptor: CHOLESTEROL, KLLA0C04147p, SULFATE ION
Authors:Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S.
Deposit date:2016-12-28
Release date:2017-05-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction
Structure, 25, 2017
3I3T
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BU of 3i3t by Molmil
Crystal structure of covalent ubiquitin-USP21 complex
Descriptor: ETHANAMINE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 21, ...
Authors:Neculai, D, Avvakumov, G.V, Walker, J.R, Xue, S, Butler-Cole, C, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2009-06-30
Release date:2009-07-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3MTN
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BU of 3mtn by Molmil
Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor
Descriptor: CHLORIDE ION, GLYCEROL, UBIQUITIN VARIANT UBV.21.4, ...
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3N3K
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BU of 3n3k by Molmil
The catalytic domain of USP8 in complex with a USP8 specific inhibitor
Descriptor: Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 8, ZINC ION
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Allali-Hassani, A, Lam, R, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2010-05-20
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
1JPA
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BU of 1jpa by Molmil
Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, neural kinase, Nuk=Eph/Elk/Eck family receptor-like tyrosine kinase
Authors:Wybenga-Groot, L.E, Pawson, T, Sicheri, F.
Deposit date:2001-08-01
Release date:2001-10-03
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.
Cell(Cambridge,Mass.), 106, 2001
4J7P
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BU of 4j7p by Molmil
Crystal structure of Saccharomyces cerevisiae Sfh3
Descriptor: Phosphatidylinositol transfer protein PDR16
Authors:Yang, H, Im, Y.J.
Deposit date:2013-02-14
Release date:2013-07-03
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural determinants for phosphatidylinositol recognition by Sfh3 and substrate-induced dimer-monomer transition during lipid transfer cycles.
Febs Lett., 587, 2013
4J7Q
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BU of 4j7q by Molmil
Crystal structure of Saccharomyces cerevisiae Sfh3 complexed with phosphatidylinositol
Descriptor: (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Phosphatidylinositol transfer protein PDR16
Authors:Yang, H, Im, Y.J.
Deposit date:2013-02-14
Release date:2013-07-03
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural determinants for phosphatidylinositol recognition by Sfh3 and substrate-induced dimer-monomer transition during lipid transfer cycles.
Febs Lett., 587, 2013
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數據於2024-06-12公開中

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