4RR4
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![BU of 4rr4 by Molmil](/molmil-images/mine/4rr4) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367 | Descriptor: | 2-chloro-N-[3-(4-{[(2Z)-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enoyl]amino}phenoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxamide, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Ren, X, Zhu, J, Li, H. | Deposit date: | 2014-11-06 | Release date: | 2015-11-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367 TO BE PUBLISHED
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4RKA
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![BU of 4rka by Molmil](/molmil-images/mine/4rka) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347 | Descriptor: | 2-{[5-(naphthalen-1-ylmethyl)-4-oxo-4H-1lambda~4~,3-thiazol-2-yl]amino}benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Ren, X, Zhu, J, Li, H. | Deposit date: | 2014-10-12 | Release date: | 2015-11-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347 TO BE PUBLISHED
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4RK8
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![BU of 4rk8 by Molmil](/molmil-images/mine/4rk8) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356 | Descriptor: | 5-fluoro-2-{[(5Z)-5-(naphthalen-1-ylmethylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]amino}benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Ren, X, Zhu, J, Li, H. | Deposit date: | 2014-10-12 | Release date: | 2015-11-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356 TO BE PUBLISHED
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4RLI
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![BU of 4rli by Molmil](/molmil-images/mine/4rli) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048 | Descriptor: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | Authors: | Zhu, L, Ren, X, Zhu, J, Li, H. | Deposit date: | 2014-10-17 | Release date: | 2015-11-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048 TO BE PUBLISHED
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7JTL
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![BU of 7jtl by Molmil](/molmil-images/mine/7jtl) | Structure of SARS-CoV-2 ORF8 accessory protein | Descriptor: | ORF8 protein, SODIUM ION | Authors: | Flower, T.G, Buffalo, C.Z, Hooy, R.M, Allaire, M, Ren, X, Hurley, J.H. | Deposit date: | 2020-08-18 | Release date: | 2020-08-26 | Last modified: | 2021-02-10 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein. Proc.Natl.Acad.Sci.USA, 118, 2021
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6CM9
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![BU of 6cm9 by Molmil](/molmil-images/mine/6cm9) | Structure of the cargo bound AP-1:Arf1:tetherin-Nef closed trimer monomeric subunit | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | Authors: | Morris, K.L, Buffalo, C.Z, Ren, X, Hurley, J.H. | Deposit date: | 2018-03-03 | Release date: | 2018-08-08 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell, 174, 2018
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6DFF
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![BU of 6dff by Molmil](/molmil-images/mine/6dff) | Structure of the cargo bound AP-1:Arf1:tetherin-Nef monomer | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | Authors: | Morris, K.L, Buffalo, C.Z, Ren, X, Hurley, J.H. | Deposit date: | 2018-05-14 | Release date: | 2018-08-08 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell, 174, 2018
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7V7W
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![BU of 7v7w by Molmil](/molmil-images/mine/7v7w) | Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex with oleoylethanolamide (OEA) | Descriptor: | (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha | Authors: | Diao, X, Ren, X, Li, F.W, Zhang, M, Sun, X, Wu, D. | Deposit date: | 2021-08-21 | Release date: | 2022-05-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.507 Å) | Cite: | Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha. Nat Commun, 13, 2022
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7V7L
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![BU of 7v7l by Molmil](/molmil-images/mine/7v7l) | Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha | Authors: | Diao, X, Ren, X, Li, F.W, Sun, X, Wu, D. | Deposit date: | 2021-08-21 | Release date: | 2022-05-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha. Nat Commun, 13, 2022
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5HM9
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![BU of 5hm9 by Molmil](/molmil-images/mine/5hm9) | Crystal structure of MamO protease domain from Magnetospirillum magneticum (apo form) | Descriptor: | MamO protease domain, poly(UNK) | Authors: | Hershey, D.M, Ren, X, Hurley, J.H, Komeili, A. | Deposit date: | 2016-01-15 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | MamO Is a Repurposed Serine Protease that Promotes Magnetite Biomineralization through Direct Transition Metal Binding in Magnetotactic Bacteria. Plos Biol., 14, 2016
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5HMA
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![BU of 5hma by Molmil](/molmil-images/mine/5hma) | Crystal structure of MamO protease domain from Magnetospirillum magneticum (Ni bound form) | Descriptor: | CHLORIDE ION, NICKEL (II) ION, Trypsin-like serine protease, ... | Authors: | Hershey, D.M, Ren, X, Hurley, J.H, Komeili, A. | Deposit date: | 2016-01-15 | Release date: | 2016-02-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | MamO Is a Repurposed Serine Protease that Promotes Magnetite Biomineralization through Direct Transition Metal Binding in Magnetotactic Bacteria. Plos Biol., 14, 2016
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3SPD
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![BU of 3spd by Molmil](/molmil-images/mine/3spd) | Crystal structure of aprataxin ortholog Hnt3 in complex with DNA | Descriptor: | Aprataxin-like protein, DNA (5'-D(*GP*TP*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*TP*GP*AP*G)-3'), DNA (5'-D(*TP*AP*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*AP*C)-3'), ... | Authors: | Gong, Y, Zhu, D, Ding, J, Dou, C, Ren, X, Jiang, T, Wang, D. | Deposit date: | 2011-07-01 | Release date: | 2011-10-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.912 Å) | Cite: | Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA Nat.Struct.Mol.Biol., 18, 2011
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4JGD
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![BU of 4jgd by Molmil](/molmil-images/mine/4jgd) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016 | Descriptor: | 1-[4-methyl-2-(naphthalen-2-ylamino)-1,3-thiazol-5-yl]ethanone, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Zhu, J, Ren, X, Li, H. | Deposit date: | 2013-03-01 | Release date: | 2014-03-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016 TO BE PUBLISHED
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4JTT
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![BU of 4jtt by Molmil](/molmil-images/mine/4jtt) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 066 | Descriptor: | 2,4-dimethyl-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | Authors: | Zhu, L, Li, H, Zhu, J, Ren, X. | Deposit date: | 2013-03-24 | Release date: | 2014-03-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 TO BE PUBLISHED
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4JTU
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![BU of 4jtu by Molmil](/molmil-images/mine/4jtu) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with brequinar analogue | Descriptor: | 6-bromo-2-{4-[(2R)-butan-2-yl]phenyl}-3-methylquinoline-4-carboxylic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Zhu, J, Ren, X, Li, H. | Deposit date: | 2013-03-24 | Release date: | 2014-03-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 To be Published
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4JS3
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![BU of 4js3 by Molmil](/molmil-images/mine/4js3) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 | Descriptor: | 2-chloro-4-methyl-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide, ACETIC ACID, Dihydroorotate dehydrogenase (quinone), ... | Authors: | Zhu, L, Li, H, Zhu, J, Ren, X. | Deposit date: | 2013-03-22 | Release date: | 2014-03-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 TO BE PUBLISHED
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4JTS
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![BU of 4jts by Molmil](/molmil-images/mine/4jts) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 072 | Descriptor: | 4-methyl-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | Authors: | Zhu, L, Zhu, J, Ren, X, Li, H. | Deposit date: | 2013-03-24 | Release date: | 2014-03-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.206 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 To be Published
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3SP4
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![BU of 3sp4 by Molmil](/molmil-images/mine/3sp4) | Crystal structure of aprataxin ortholog Hnt3 from Schizosaccharomyces pombe | Descriptor: | Aprataxin-like protein, SULFATE ION, ZINC ION | Authors: | Gong, Y, Zhu, D, Ding, J, Dou, C, Ren, X, Jiang, T, Wang, D. | Deposit date: | 2011-07-01 | Release date: | 2011-10-12 | Last modified: | 2013-07-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA Nat.Struct.Mol.Biol., 18, 2011
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3SPL
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![BU of 3spl by Molmil](/molmil-images/mine/3spl) | Crystal structure of aprataxin ortholog Hnt3 in complex with DNA and AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Aprataxin-like protein, DNA (5'-D(*GP*TP*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*TP*GP*AP*G)-3'), ... | Authors: | Gong, Y, Zhu, D, Ding, J, Dou, C, Ren, X, Jiang, T, Wang, D. | Deposit date: | 2011-07-02 | Release date: | 2011-10-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA Nat.Struct.Mol.Biol., 18, 2011
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3V1S
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![BU of 3v1s by Molmil](/molmil-images/mine/3v1s) | Scaffold tailoring by a newly detected Pictet-Spenglerase ac-tivity of strictosidine synthase (STR1): from the common tryp-toline skeleton to the rare piperazino-indole framework | Descriptor: | 2-(1H-indol-1-yl)ethanamine, Strictosidine synthase | Authors: | Wu, F, Zhu, H, Sun, L, Rajendran, C, Wang, M, Ren, X, Panjikar, S, Cherkasov, A, Zou, H, Stoeckigt, J. | Deposit date: | 2011-12-10 | Release date: | 2012-02-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.328 Å) | Cite: | Scaffold Tailoring by a Newly Detected Pictet-Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework J.Am.Chem.Soc., 134, 2012
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4LS1
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![BU of 4ls1 by Molmil](/molmil-images/mine/4ls1) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312 | Descriptor: | 2-[(E)-{2-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | Authors: | Zhu, L, Li, H, Ren, X, Zhu, J. | Deposit date: | 2013-07-21 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312 To be Published
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4LS2
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![BU of 4ls2 by Molmil](/molmil-images/mine/4ls2) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A313 | Descriptor: | 2-[(E)-{2-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | Authors: | Zhu, L, Li, H, Ren, X, Zhu, J. | Deposit date: | 2013-07-21 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A313 To be Published
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4LS0
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![BU of 4ls0 by Molmil](/molmil-images/mine/4ls0) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH01B0033 | Descriptor: | 2-{(E)-[2-(4-phenyl-1,3-thiazol-2-yl)hydrazinylidene]methyl}benzaldehyde, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Li, H, Ren, X, Zhu, J. | Deposit date: | 2013-07-21 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DHO1B0033 To be Published
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7XSV
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![BU of 7xsv by Molmil](/molmil-images/mine/7xsv) | Crystal Structures of PIM1 in Complex with Macrocyclic Compound H3 | Descriptor: | 8-Methyl-2,5,20-trioxa-8,13,17-triazatetracyclo[11.10.2.014,19.021,25]pentacosa-1(24),14(19),15,17,21(25),22-hexaene, Serine/threonine-protein kinase pim-1 | Authors: | Shen, C, Xie, Y, Ren, X, Zhou, Y, Niu, H. | Deposit date: | 2022-05-15 | Release date: | 2022-07-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Design, synthesis, and bioactivity evaluation of macrocyclic benzo[b]pyrido[4,3-e][1,4]oxazine derivatives as novel Pim-1 kinase inhibitors. Bioorg.Med.Chem.Lett., 72, 2022
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2M2L
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![BU of 2m2l by Molmil](/molmil-images/mine/2m2l) | |