3V1S

Scaffold tailoring by a newly detected Pictet-Spenglerase ac-tivity of strictosidine synthase (STR1): from the common tryp-toline skeleton to the rare piperazino-indole framework

Summary for 3V1S

Entry DOI	10.2210/pdb3v1s/pdb
Descriptor	Strictosidine synthase, 2-(1H-indol-1-yl)ethanamine (3 entities in total)
Functional Keywords	strictosidine synthase, alkaloid biosynthesis, strictosidine synthase family, lyase
Biological source	Rauvolfia serpentina (devilpepper)
Cellular location	Vacuole: P68175
Total number of polymer chains	2
Total formula weight	71852.31
Authors	Wu, F.,Zhu, H.,Sun, L.,Rajendran, C.,Wang, M.,Ren, X.,Panjikar, S.,Cherkasov, A.,Zou, H.,Stoeckigt, J. (deposition date: 2011-12-10, release date: 2012-02-29, Last modification date: 2023-11-08)
Primary citation	Wu, F.,Zhu, H.,Sun, L.,Rajendran, C.,Wang, M.,Ren, X.,Panjikar, S.,Cherkasov, A.,Zou, H.,Stockigt, J. Scaffold Tailoring by a Newly Detected Pictet-Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework J.Am.Chem.Soc., 134:1498-1500, 2012 Cited by PubMed: 22229634 DOI: 10.1021/ja211524d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.328 Å)

Structure validation