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4C1L
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BU of 4c1l by Molmil
Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino- heptulosonate 7-phosphate synthase I181D interface mutant
Descriptor: 2-dehydro-3-deoxyphosphoheptonate aldolase, CHLORIDE ION, MANGANESE (II) ION, ...
Authors:Nazmi, A.R, Schofield, L.R, Dobson, R.C.J, Jameson, G.B, Parker, E.J.
Deposit date:2013-08-13
Release date:2013-11-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Destabilization of the homotetrameric assembly of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from the hyperthermophile Pyrococcus furiosus enhances enzymatic activity.
J. Mol. Biol., 426, 2014
3ZOK
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BU of 3zok by Molmil
Structure of 3-Dehydroquinate Synthase from Actinidia chinensis in complex with NAD
Descriptor: 3-DEHYDROQUINATE SYNTHASE, DI(HYDROXYETHYL)ETHER, GLYCINE, ...
Authors:Mittelstaedt, G, Negron, L, Schofield, L.R, Marsh, K, Parker, E.J.
Deposit date:2013-02-22
Release date:2013-08-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biochemical and structural characterisation of dehydroquinate synthase from the New Zealand kiwifruit Actinidia chinensis.
Arch. Biochem. Biophys., 537, 2013
4UMC
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BU of 4umc by Molmil
Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water
Descriptor: L-PHOSPHOLACTATE, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Heyes, L.C, Reichau, S, Cross, P.J, Parker, E.J.
Deposit date:2014-05-16
Release date:2014-10-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water.
Bioorg.Chem., 57, 2014
4UMB
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BU of 4umb by Molmil
Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water
Descriptor: (2R)-2-(phosphonooxy)propanoic acid, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Heyes, L.C, Reichau, S, Cross, P.J, Parker, E.J.
Deposit date:2014-05-16
Release date:2014-10-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water.
Bioorg.Chem., 57, 2014
4UMA
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BU of 4uma by Molmil
Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3 deoxy D arabino heptulosonate 7 phosphate synthase the importance of accommodating the active site water
Descriptor: (E)-2-METHYL-3-PHOSPHONOACRYLATE, MANGANESE (II) ION, PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE
Authors:Heyes, L.C, Reichau, S, Cross, P.J, Parker, E.J.
Deposit date:2014-05-16
Release date:2014-10-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water.
Bioorg.Chem., 57, 2014
3FYO
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BU of 3fyo by Molmil
Crystal structure of the triple mutant (N23C/D247E/P249A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Descriptor: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase, CHLORIDE ION, MANGANESE (II) ION, ...
Authors:Jameson, G.B, Parker, E.J, Cochrane, F.P, Patchett, M.L.
Deposit date:2009-01-22
Release date:2009-03-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Reversing evolution: re-establishing obligate metal ion dependence in a metal-independent KDO8P synthase
J.Mol.Biol., 390, 2009
3FYP
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BU of 3fyp by Molmil
Crystal structure of the quadruple mutant (N23C/C246S/D247E/P249A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Descriptor: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase, CHLORIDE ION, GLYCEROL, ...
Authors:Jameson, G.B, Parker, E.J, Cochrane, F.P, Patchett, M.L.
Deposit date:2009-01-22
Release date:2009-03-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Reversing evolution: re-establishing obligate metal ion dependence in a metal-independent KDO8P synthase
J.Mol.Biol., 390, 2009
2B7O
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BU of 2b7o by Molmil
The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase from Mycobacterium tuberculosis
Descriptor: 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG, MANGANESE (II) ION, O-DODECANYL OCTAETHYLENE GLYCOL, ...
Authors:Webby, C.J, Baker, H.M, Lott, J.S, Baker, E.N, Parker, E.J, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2005-10-05
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes
J.Mol.Biol., 354, 2005
4GRS
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BU of 4grs by Molmil
Crystal structure of a chimeric DAH7PS
Descriptor: Phospho-2-dehydro-3-deoxyheptonate aldolase, 2-dehydro-3-deoxyphosphoheptonate aldolase, TYROSINE
Authors:Cross, P.J, Allison, T.M, Dobson, R.C.J, Jameson, G.B, Parker, E.J.
Deposit date:2012-08-26
Release date:2013-02-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain
Proc.Natl.Acad.Sci.USA, 110, 2013
4HSO
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BU of 4hso by Molmil
Crystal structure of S213G variant DAH7PS from Neisseria meningitidis
Descriptor: 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ...
Authors:Cross, P.J, Pietersma, A.L, Allison, T.M, Wilson-Coutts, S.M, Cochrane, F.C, Parker, E.J.
Deposit date:2012-10-30
Release date:2013-09-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine.
Protein Sci., 22, 2013
4HSN
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BU of 4hsn by Molmil
Crystal structure of DAH7PS from Neisseria meningitidis
Descriptor: 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ...
Authors:Cross, P.J, Pietersma, A.L, Allison, T.M, Wilson-Coutts, S.M, Cochrane, F.C, Parker, E.J.
Deposit date:2012-10-30
Release date:2013-09-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine.
Protein Sci., 22, 2013
3QQ1
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BU of 3qq1 by Molmil
Crystal structure of a double mutant [A58P, DEL(N59)] of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Descriptor: 2-dehydro-3-deoxyphosphooctonate aldolase
Authors:Allison, T.M, Jameson, G.B, Parker, E.J.
Deposit date:2011-02-14
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Biochemistry, 50, 2011
3QQ0
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BU of 3qq0 by Molmil
Crystal structure of a deletion mutant (N59) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Descriptor: 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, GLYCEROL, ...
Authors:Allison, T.M, Jameson, G.B, Parker, E.J.
Deposit date:2011-02-14
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Biochemistry, 50, 2011
3RMJ
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BU of 3rmj by Molmil
Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis
Descriptor: 2-isopropylmalate synthase, GLYCEROL, MAGNESIUM ION, ...
Authors:Huisman, F.H.A, Baker, H.M, Koon, N, Baker, E.N, Parker, E.J.
Deposit date:2011-04-20
Release date:2012-03-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Biochemistry, 51, 2012
3PFP
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BU of 3pfp by Molmil
Structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with an active site inhibitor
Descriptor: (2R)-2,7-bis(phosphonooxy)heptanoic acid, (2S)-2,7-bis(phosphonooxy)heptanoic acid, CHLORIDE ION, ...
Authors:Reichau, S, Jiao, W, Walker, S.R, Hutton, R.D, Parker, E.J, Baker, E.N.
Deposit date:2010-10-28
Release date:2011-03-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design
J.Biol.Chem., 286, 2011
3PG8
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BU of 3pg8 by Molmil
Truncated form of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Thermotoga maritima
Descriptor: AZIDE ION, GLYCEROL, Phospho-2-dehydro-3-deoxyheptonate aldolase
Authors:Cross, P.J, Dobson, R.C.J, Patchett, M.L, Parker, E.J.
Deposit date:2010-10-31
Release date:2011-01-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis
J.Biol.Chem., 286, 2011
3PG9
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BU of 3pg9 by Molmil
Thermotoga maritima DAH7P synthase in complex with inhibitor
Descriptor: AZIDE ION, CHLORIDE ION, NITRATE ION, ...
Authors:Cross, P.J, Dobson, R.C.J, Patchett, M.L, Parker, E.J.
Deposit date:2010-10-31
Release date:2011-01-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis
J.Biol.Chem., 286, 2011
3QPZ
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BU of 3qpz by Molmil
Crystal structure of the N59A mutant of the 3-deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Descriptor: 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, GLYCEROL, ...
Authors:Allison, T.M, Jameson, G.B, Parker, E.J, Cochrane, F.C.
Deposit date:2011-02-14
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Biochemistry, 50, 2011
3QPY
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BU of 3qpy by Molmil
Crystal structure of a mutant (K57A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Descriptor: 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, GLYCEROL, ...
Authors:Allison, T.M, Jameson, G.B, Parker, E.J.
Deposit date:2011-02-14
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Biochemistry, 50, 2011
3RZI
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BU of 3rzi by Molmil
The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis cocrystallized and complexed with phenylalanine and tryptophan
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Jiao, W, Jameson, G.B, Hutton, R.D, Parker, E.J.
Deposit date:2011-05-11
Release date:2012-01-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Dynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allostery.
J.Mol.Biol., 415, 2012
4YB5
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BU of 4yb5 by Molmil
Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni in complex with the allosteric inhibitor histidine
Descriptor: ATP phosphoribosyltransferase, DI(HYDROXYETHYL)ETHER, HISTIDINE, ...
Authors:Mittelstaedt, G, Moggre, G.-J, Parker, E.J.
Deposit date:2015-02-18
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail.
Protein Sci., 25, 2016
4YB6
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BU of 4yb6 by Molmil
Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni in complex with the inhibitors AMP and histidine
Descriptor: ADENOSINE MONOPHOSPHATE, ATP phosphoribosyltransferase, DI(HYDROXYETHYL)ETHER, ...
Authors:Mittelstaedt, G, Moggre, G.-J, Parker, E.J.
Deposit date:2015-02-18
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail.
Protein Sci., 25, 2016
4YB7
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BU of 4yb7 by Molmil
Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni in complex with ATP
Descriptor: ACETIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ATP phosphoribosyltransferase, ...
Authors:Mittelstaedt, G, Moggre, G.-J, Parker, E.J.
Deposit date:2015-02-18
Release date:2016-03-09
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail.
Protein Sci., 25, 2016
3STF
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BU of 3stf by Molmil
Crystal structure of a mutant (S211A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Descriptor: 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, GLYCEROL, ...
Authors:Allison, T.M, Jameson, G.B, Gloyne, B.J, Parker, E.J.
Deposit date:2011-07-09
Release date:2011-11-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An Extended (beta)7(alpha)7 Substrate-Binding Loop Is Essential for Efficient Catalysis by 3-Deoxy-D-manno-Octulosonate 8-Phosphate Synthase
Biochemistry, 50, 2011
3STC
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BU of 3stc by Molmil
Crystal structure of loop 7 truncated mutant of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Descriptor: 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, SODIUM ION
Authors:Allison, T.M, Jameson, G.B, Parker, E.J.
Deposit date:2011-07-09
Release date:2011-11-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:An Extended (beta)7(alpha)7 Substrate-Binding Loop Is Essential for Efficient Catalysis by 3-Deoxy-D-manno-Octulosonate 8-Phosphate Synthase
Biochemistry, 50, 2011

221716

數據於2024-06-26公開中

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