4UMC
Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water
Summary for 4UMC
Entry DOI | 10.2210/pdb4umc/pdb |
Related | 4UMA 4UMB |
Descriptor | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, MANGANESE (II) ION, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | transferase, dah7ps, dahps, aromatic amino acids, shikimate pathway, oxocarbenium ion, enzyme inhibitors, meningitis |
Biological source | NEISSERIA MENINGITIDIS |
Total number of polymer chains | 4 |
Total formula weight | 156128.40 |
Authors | Heyes, L.C.,Reichau, S.,Cross, P.J.,Parker, E.J. (deposition date: 2014-05-16, release date: 2014-10-08, Last modification date: 2024-01-10) |
Primary citation | Heyes, L.C.,Reichau, S.,Cross, P.J.,Jameson, G.B.,Parker, E.J. Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water. Bioorg.Chem., 57:242-, 2014 Cited by PubMed: 25245459DOI: 10.1016/J.BIOORG.2014.08.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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