2YPQ

3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with tryptophan and tyrosine bound

Summary for 2YPQ

• Entry DOI: 10.2210/pdb2ypq/pdb
• Related: 2YPO 2YPP
• Descriptor: PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE AROG, TYROSINE, MANGANESE (II) ION, ... (9 entities in total)
• Functional Keywords: shikimate pathway, transferase, aromatic amino acid biosynthesis, allostery
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 2
• Total formula weight: 103283.78

Authors

Blackmore, N.J.,Reichau, S.,Jiao, W.,Hutton, R.D.,Baker, E.N.,Jameson, G.B.,Parker, E.J. (deposition date: 2012-10-31, release date: 2013-01-09, Last modification date: 2023-12-20)

• Primary citation: Blackmore, N.J.,Reichau, S.,Jiao, W.,Hutton, R.D.,Baker, E.N.,Jameson, G.B.,Parker, E.J.; Three Sites and You are Out: Ternary Synergistic Allostery Controls Aromatic Aminoacid Biosynthesis in Mycobacterium Tuberculosis.; J.Mol.Biol., 425:1582-, 2013; PubMed: 23274137; DOI: 10.1016/J.JMB.2012.12.019

Experimental method

X-RAY DIFFRACTION (2.76 Å)