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6RRO
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BU of 6rro by Molmil
Solution NMR structure of the peptide 536_2 from medicinal leech Hirudo medicinalis in dodecylphosphocholine micelles
Descriptor: peptide 536_2
Authors:Nadezhdin, K.D, Grafskaia, E.N, Arseniev, A.S, Lazarev, V.N.
Deposit date:2019-05-20
Release date:2019-07-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens.
Eur.J.Med.Chem., 180, 2019
6RRL
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BU of 6rrl by Molmil
Solution NMR structure of the peptide 3967 from medicinal leech Hirudo medicinalis in dodecylphosphocholine micelles
Descriptor: peptide 3967
Authors:Nadezhdin, K.D, Grafskaia, E.N, Arseniev, A.S, Lazarev, V.N.
Deposit date:2019-05-20
Release date:2019-07-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens.
Eur.J.Med.Chem., 180, 2019
9B35
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BU of 9b35 by Molmil
Ligand-binding and transmembrane domains of kainate receptor GluK2 in the open state, a complex with agonist glutamate and positive allosteric modulator BPAM344
Descriptor: GLUTAMIC ACID, Glutamate receptor ionotropic, kainate 2
Authors:Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
Deposit date:2024-03-18
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Kainate receptor channel opening and gating mechanism.
Nature, 2024
9B38
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BU of 9b38 by Molmil
Kainate receptor GluK2 in complex with agonist glutamate with pseudo 4-fold symmetrical ligand-binding domain layer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
Authors:Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
Deposit date:2024-03-18
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Kainate receptor channel opening and gating mechanism.
Nature, 2024
9B36
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BU of 9b36 by Molmil
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to two concanavalin A dimers. Composite map.
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
Deposit date:2024-03-18
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.29 Å)
Cite:Kainate receptor channel opening and gating mechanism.
Nature, 2024
9B33
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BU of 9b33 by Molmil
Structure of concanavalin A (ConA) dimer from the open-state structure of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one ConA dimer. Type II interface between GluK2 ligand-binding domain and ConA
Descriptor: CALCIUM ION, Concanavalin V, ZINC ION
Authors:Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
Deposit date:2024-03-18
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.07 Å)
Cite:Kainate receptor channel opening and gating mechanism.
Nature, 2024
9B37
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BU of 9b37 by Molmil
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one concanavalin A dimer. Composite map.
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
Deposit date:2024-03-18
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (6.66 Å)
Cite:Kainate receptor channel opening and gating mechanism.
Nature, 2024
9B39
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BU of 9b39 by Molmil
Kainate receptor GluK2 in complex with agonist glutamate with asymmetric ligand-binding domain layer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
Authors:Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
Deposit date:2024-03-18
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Kainate receptor channel opening and gating mechanism.
Nature, 2024
9B34
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BU of 9b34 by Molmil
Structure of concanavalin A (ConA) dimer from the open-state structure of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to two ConA dimers. Type I interface between GluK2 ligand-binding domain and ConA
Descriptor: CALCIUM ION, Concanavalin A, ZINC ION
Authors:Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
Deposit date:2024-03-18
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Kainate receptor channel opening and gating mechanism.
Nature, 2024
2JWM
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BU of 2jwm by Molmil
NMR spatial srtucture of ternary complex kalata B7/Mn2+/DPC micelle
Descriptor: Kalata-B7
Authors:Nadezhdin, K.D, Shenkarev, Z.O, Skjeldal, L, Arseniev, A.S.
Deposit date:2007-10-16
Release date:2008-03-11
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Divalent cation coordination and mode of membrane interaction in cyclotides: NMR spatial structure of ternary complex Kalata B7/Mn(2+)/DPC micelle
J.Inorg.Biochem., 102, 2008
7S8B
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BU of 7s8b by Molmil
Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ...
Authors:Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2021-09-17
Release date:2021-11-17
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.43 Å)
Cite:Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
8T1D
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BU of 8t1d by Molmil
Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD
Descriptor: (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera
Authors:Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-06-02
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
8T1E
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BU of 8t1e by Molmil
Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD
Descriptor: (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4,Enhanced green fluorescent protein, ...
Authors:Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-06-02
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
8T1F
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BU of 8t1f by Molmil
Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera
Authors:Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-06-02
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
7LR0
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BU of 7lr0 by Molmil
Structure of squirrel TRPV1 in complex with capsaicin
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, Osm-9-like TRP channel 1, ...
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2021-02-15
Release date:2021-04-21
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.81 Å)
Cite:Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Nat Commun, 12, 2021
7LQZ
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BU of 7lqz by Molmil
Structure of squirrel TRPV1 in complex with RTX
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Osm-9-like TRP channel 1, SODIUM ION, ...
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2021-02-15
Release date:2021-04-21
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Nat Commun, 12, 2021
7MIJ
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BU of 7mij by Molmil
Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2021-04-17
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (1.98 Å)
Cite:Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
Nat.Struct.Mol.Biol., 28, 2021
7MIM
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BU of 7mim by Molmil
Mouse TRPV3 in cNW11 nanodiscs, closed state at 4 degrees Celsius
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2021-04-17
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
Nat.Struct.Mol.Biol., 28, 2021
7PH8
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BU of 7ph8 by Molmil
Structure of Insulin-like growth factor 1 receptor's transmembrane domain
Descriptor: Insulin-like growth factor 1 receptor
Authors:Bershatsky, Y.V, Nadezhdin, K.D, Bocharova, O.V, Bocharov, E.V.
Deposit date:2021-08-16
Release date:2022-08-24
Method:SOLUTION NMR
Cite:Structure of Insulin-like growth factor 1 receptor's transmembrane domain
To Be Published
7D2K
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BU of 7d2k by Molmil
Crystal structure of rat TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a
Descriptor: 1-(5-bromanylpyridin-3-yl)-4-[4-(3-methylphenyl)cyclohexyl]piperazin-4-ium, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6
Authors:Singh, A.K, Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2020-09-16
Release date:2021-10-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.698 Å)
Cite:Inactivation-mimicking block of the epithelial calcium channel TRPV6.
Sci Adv, 6, 2020
1ZNU
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BU of 1znu by Molmil
Structure of cyclotide Kalata B1 in DPC micelles solution
Descriptor: Kalata B1
Authors:Shenkarev, Z.O, Nadezhdin, K.D, Sobol, V.A, Sobol, A.G, Skjeldal, L, Arseniev, A.S.
Deposit date:2005-05-12
Release date:2006-04-25
Last modified:2020-02-05
Method:SOLUTION NMR
Cite:Conformation and mode of membrane interaction in cyclotides. Spatial structure of kalata B1 bound to a dodecylphosphocholine micelle.
Febs J., 273, 2006
7UGG
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BU of 7ugg by Molmil
Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Dyclonine, SODIUM ION, ...
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2022-03-24
Release date:2022-06-08
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine.
Nat Commun, 13, 2022
6RSM
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BU of 6rsm by Molmil
Solution NMR structure of the peptide 12530 from medicinal leech Hirudo medicinalis in dodecylphosphocholine micelles
Descriptor: peptide 12530
Authors:Talyzina, I.A, Nadezhdin, K.D, Grafskaia, E.N, Arseniev, A.S, Lazarev, V.N.
Deposit date:2019-05-21
Release date:2019-07-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens.
Eur.J.Med.Chem., 180, 2019
8FOA
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BU of 8foa by Molmil
Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2022-12-30
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.
Nat Commun, 14, 2023
8FOB
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BU of 8fob by Molmil
Cryo-EM structure of human TRPV6 in the open state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ...
Authors:Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2022-12-30
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (2.71 Å)
Cite:Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.
Nat Commun, 14, 2023

221051

數據於2024-06-12公開中

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