9B36
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to two concanavalin A dimers. Composite map.
Summary for 9B36
| Entry DOI | 10.2210/pdb9b36/pdb |
| EMDB information | 44129 |
| Descriptor | Glutamate receptor ionotropic, kainate 2, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, ... (15 entities in total) |
| Functional Keywords | kainate receptor, gluk2, positive allosteric modulator, bpam344, open, concanavalin a, cona, glutamate, membrane protein |
| Biological source | Rattus norvegicus (Norway rat) More |
| Total number of polymer chains | 8 |
| Total formula weight | 549861.95 |
| Authors | Nadezhdin, K.D.,Gangwar, S.P.,Sobolevsky, A.I. (deposition date: 2024-03-18, release date: 2024-05-22, Last modification date: 2024-06-05) |
| Primary citation | Gangwar, S.P.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Yen, L.Y.,Newton, T.P.,Aktolun, M.,Kurnikova, M.G.,Sobolevsky, A.I. Kainate receptor channel opening and gating mechanism. Nature, 2024 Cited by PubMed: 38778115DOI: 10.1038/s41586-024-07475-0 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (4.29 Å) |
Structure validation
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