9B36

Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to two concanavalin A dimers. Composite map.

Functional Information from PROSITE/UniProt

site_id	PS00307
Number of Residues	7
Details	LECTIN_LEGUME_BETA Legume lectins beta-chain signature. VAVELDT

Chain	Residue	Details
E	VAL5-THR11

---

site_id	PS00308
Number of Residues	10
Details	LECTIN_LEGUME_ALPHA Legume lectins alpha-chain signature. LPEWVRVGLS

Chain	Residue	Details
E	LEU85-SER94

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000269|PubMed:27737777

Chain	Residue	Details
E	GLU8
E	ARG228
F	GLU8
F	ASP10
F	TYR12
F	ASN14
F	ASP19
F	HIS24
F	ALA70
F	GLY98
F	ASP208
E	ASP10
F	ARG228
G	GLU8
G	ASP10
G	TYR12
G	ASN14
G	ASP19
G	HIS24
G	ALA70
G	GLY98
G	ASP208
E	TYR12
G	ARG228
H	GLU8
H	ASP10
H	TYR12
H	ASN14
H	ASP19
H	HIS24
H	ALA70
H	GLY98
H	ASP208
E	ASN14
H	ARG228
E	ASP19
E	HIS24
E	ALA70
E	GLY98
E	ASP208

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ASP562-ALA582
D	ASP562-ALA582
D	ILE639-LEU659
D	ILE820-GLY840
A	ILE639-LEU659
A	ILE820-GLY840
B	ASP562-ALA582
B	ILE639-LEU659
B	ILE820-GLY840
C	ASP562-ALA582
C	ILE639-LEU659
C	ILE820-GLY840

---

site_id	SWS_FT_FI3
Number of Residues	488
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:8163463

Chain	Residue	Details
A	ARG583-GLY638
A	GLU841-ALA908
B	ARG583-GLY638
B	GLU841-ALA908
C	ARG583-GLY638
C	GLU841-ALA908
D	ARG583-GLY638
D	GLU841-ALA908

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:15721240, ECO:0000269|PubMed:17115050, ECO:0007744|PDB:1S50, ECO:0007744|PDB:1S7Y, ECO:0007744|PDB:2I0B, ECO:0007744|PDB:2I0C

Chain	Residue	Details
A	PRO516
B	ALA689
B	THR690
B	GLU738
C	PRO516
C	ALA518
C	ARG523
C	ALA689
A	ALA518
A	ARG523
A	ALA689
A	THR690
A	GLU738
B	PRO516
B	ALA518
B	ARG523
C	THR690
C	GLU738
D	PRO516
D	ALA518
D	ARG523
D	ALA689
D	THR690
D	GLU738

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q13002

Chain	Residue	Details
A	SER846
A	SER868
B	SER846
B	SER868
C	SER846
C	SER868
D	SER846
D	SER868

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21791290

Chain	Residue	Details
A	ASN67
D	ASN67
D	ASN378
D	ASN412
A	ASN378
A	ASN412
B	ASN67
B	ASN378
B	ASN412
C	ASN67
C	ASN378
C	ASN412

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN73
C	ASN275
C	ASN430
C	ASN546
D	ASN73
D	ASN275
D	ASN430
D	ASN546
A	ASN275
A	ASN430
A	ASN546
B	ASN73
B	ASN275
B	ASN430
B	ASN546
C	ASN73

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15677325

Chain	Residue	Details
A	ASN423
B	ASN423
C	ASN423
D	ASN423

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15677325, ECO:0000269|PubMed:8163463

Chain	Residue	Details
A	ASN751
C	ASN751
B	ASN751
D	ASN751

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000269|PubMed:17486098

Chain	Residue	Details
A	LYS886
B	LYS886
C	LYS886
D	LYS886

---