9B36
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to two concanavalin A dimers. Composite map.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutamate receptor ionotropic, kainate 2 | polymer | 912 | 102976.6 | 4 | UniProt (P42260) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluK2,Glutamate receptor 6,GluR-6,GluR6 |
| 2 | E, F, G, H (E, F, G, H) | Concanavalin A | polymer | 237 | 25622.4 | 4 | UniProt (C0HJY1) Pfam (PF00139) | Canavalia ensiformis (jack bean) | ConV |
| 3 | I, W (I, W) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1276.2 | 2 | In PDB GlyTouCan (G28663KH) | |||
| 4 | BA, CA, EA, J, JA... (b, c, e, J, j...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 12 | In PDB GlyTouCan (G42666HT) | |||
| 5 | K (K) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1479.3 | 1 | In PDB GlyTouCan (G89993FE) | |||
| 6 | AA, GA, M, S, T (a, g, M, S, T) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G15407YE) | |||
| 7 | DA, P (d, P) | beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G31886NL) | |||
| 8 | FA, R, Y (f, R, Y) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1317.2 | 3 | In PDB GlyTouCan (G39213VZ) | |||
| 9 | HA, IA, U (h, i, U) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G22573RC) | |||
| 10 | BB, KA, KB, VA (C, A, D, B) | 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | non-polymer | 242.3 | 4 | Chemie (2J9) | |||
| 11 | CB, LA, LB, WA (C, A, D, B) | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) | |||
| 12 | AB, DB, EB, FB, JB... (C, D, A, B) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 14 | Chemie (POV) | |||
| 13 | GB, HB, IB, PA, QA... (C, A, B) | CHOLESTEROL | non-polymer | 386.7 | 8 | Chemie (CLR) | |||
| 14 | OB, QB, SB, UB (E, F, G, H) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 15 | PB, RB, TB, VB (E, F, G, H) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) |
Sequence modifications
A, B, C, D: 1 - 908 (UniProt: P42260)
E, F, G, H: 1 - 237 (UniProt: C0HJY1)
| PDB | External Database | Details |
|---|---|---|
| Val 567 | Ile 567 | conflict |
| Cys 571 | Tyr 571 | conflict |
| Leu 909 | - | expression tag |
| Val 910 | - | expression tag |
| Pro 911 | - | expression tag |
| Arg 912 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 58 | Gly 58 | conflict |
| Ala 70 | Gly 70 | conflict |
| Met 129 | Val 129 | conflict |
| Glu 192 | Asp 192 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 514395.9 | |
| Branched | Number of molecules | 28 |
| Total formula weight | 19752.2 | |
| Non-Polymers* | Number of molecules | 38 |
| Total formula weight | 15713.8 | |
| All* | Total formula weight | 549861.9 |
