9B33

Structure of concanavalin A (ConA) dimer from the open-state structure of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one ConA dimer. Type II interface between GluK2 ligand-binding domain and ConA

Summary for 9B33

Entry DOI	10.2210/pdb9b33/pdb
EMDB information	44124
Descriptor	Concanavalin V, ZINC ION, CALCIUM ION (3 entities in total)
Functional Keywords	kainate receptor, gluk2, positive allosteric modulator, bpam344, open, concanavalin a, cona, glutamate, membrane protein
Biological source	Canavalia ensiformis (jack bean)
Total number of polymer chains	2
Total formula weight	51455.74
Authors	Nadezhdin, K.D.,Gangwar, S.P.,Sobolevsky, A.I. (deposition date: 2024-03-18, release date: 2024-05-22, Last modification date: 2024-06-05)
Primary citation	Gangwar, S.P.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Yen, L.Y.,Newton, T.P.,Aktolun, M.,Kurnikova, M.G.,Sobolevsky, A.I. Kainate receptor channel opening and gating mechanism. Nature, 2024 Cited by PubMed: 38778115 DOI: 10.1038/s41586-024-07475-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.07 Å)

Structure validation