2K27
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![BU of 2k27 by Molmil](/molmil-images/mine/2k27) | Solution structure of Human Pax8 Paired Box Domain | Descriptor: | Paired box protein Pax-8 | Authors: | Codutti, L, Esposito, G, Corazza, A, Fogolari, F, Tell, G, Vascotto, C, van Ingen, H, Boelens, R, Viglino, P, Quadrifoglio, F. | Deposit date: | 2008-03-26 | Release date: | 2008-09-30 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | The Solution Structure of DNA-free Pax-8 Paired Box Domain Accounts for Redox Regulation of Transcriptional Activity in the Pax Protein Family. J.Biol.Chem., 283, 2008
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4GEQ
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![BU of 4geq by Molmil](/molmil-images/mine/4geq) | Crystal structure of the Spc24-Spc25/Cnn1 binding interface | Descriptor: | GLYCEROL, Kinetochore protein SPC24, Kinetochore protein SPC25, ... | Authors: | Malvezzi, F, Litos, G, Schleiffer, A, Heuck, A, Clausen, T, Westermann, S. | Deposit date: | 2012-08-02 | Release date: | 2013-01-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors. Embo J., 32, 2013
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1PY4
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![BU of 1py4 by Molmil](/molmil-images/mine/1py4) | Beta2 microglobulin mutant H31Y displays hints for amyloid formations | Descriptor: | Beta-2-microglobulin precursor | Authors: | Rosano, C, Zuccotti, S, Mangione, P, Giorgetti, S, Bellotti, V, Pettirossi, F, Corazza, A, Viglino, P, Esposito, G, Bolognesi, M. | Deposit date: | 2003-07-08 | Release date: | 2004-05-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | beta2-microglobulin H31Y variant 3D structure highlights the protein natural propensity towards intermolecular aggregation J.Mol.Biol., 335, 2004
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2Z9T
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![BU of 2z9t by Molmil](/molmil-images/mine/2z9t) | Crystal structure of the human beta-2 microglobulin mutant W60G | Descriptor: | Beta-2-microglobulin | Authors: | Ricagno, S, Bolognesi, M, Bellotti, V, Corazza, A, Rennella, E, Gural, D, Mimmi, M.C, Betto, E, Pucillo, C, Fogolari, F, Viglino, P, Raimondi, S, Giorgetti, S, Bolognesi, B, Merlini, G, Stoppini, M. | Deposit date: | 2007-09-26 | Release date: | 2008-04-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties J.Mol.Biol., 378, 2008
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5IL7
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![BU of 5il7 by Molmil](/molmil-images/mine/5il7) | |
4M3J
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![BU of 4m3j by Molmil](/molmil-images/mine/4m3j) | Structure of a single-domain camelid antibody fragment cAb-H7S specific of the BlaP beta-lactamase from Bacillus licheniformis | Descriptor: | Camelid heavy-chain antibody variable fragment cAb-H7S, SULFATE ION | Authors: | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | Deposit date: | 2013-08-06 | Release date: | 2014-08-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments To be Published
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5DPX
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![BU of 5dpx by Molmil](/molmil-images/mine/5dpx) | 1,2,4-Triazole-3-thione compounds as inhibitors of L1, di-zinc metallo-beta-lactamases. | Descriptor: | 5-(2-methylphenyl)-3H-1,2,4-triazole-3-thione, Metallo-beta-lactamase L1 type 3, SULFATE ION, ... | Authors: | Nauton, L, Garau, G, Khan, R, Dideberg, O. | Deposit date: | 2015-09-14 | Release date: | 2017-01-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-beta-lactamases. ChemMedChem, 12, 2017
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5TBP
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![BU of 5tbp by Molmil](/molmil-images/mine/5tbp) | Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003 | Descriptor: | ACETATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Aleshin, A.E, Liddington, R.C, Su, Y, Zhang, X. | Deposit date: | 2016-09-12 | Release date: | 2017-08-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha. Nat Commun, 8, 2017
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5N5K
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5N5J
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![BU of 5n5j by Molmil](/molmil-images/mine/5n5j) | Human MMP12 in complex with 3-(5-(1,2-dithiolan-3-yl)pentanamido)propane-1-sulfonate | Descriptor: | 3-[5-[(3~{S})-1,2-dithiolan-3-yl]pentanoylamino]propane-1-sulfonic acid, ACETOHYDROXAMIC ACID, CALCIUM ION, ... | Authors: | Calderone, V. | Deposit date: | 2017-02-14 | Release date: | 2017-11-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX). J. Med. Chem., 60, 2017
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8R4C
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![BU of 8r4c by Molmil](/molmil-images/mine/8r4c) | |
8R4D
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![BU of 8r4d by Molmil](/molmil-images/mine/8r4d) | |
5CKA
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![BU of 5cka by Molmil](/molmil-images/mine/5cka) | Human beta-2 microglobulin double mutant W60G-N83V | Descriptor: | ACETATE ION, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | Authors: | Sala, B.M, De Rosa, M, Bolognesi, M, Ricagno, S. | Deposit date: | 2015-07-15 | Release date: | 2016-05-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability. Sci Rep, 6, 2016
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5CKG
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![BU of 5ckg by Molmil](/molmil-images/mine/5ckg) | Human beta-2 microglobulin mutant V85E | Descriptor: | ACETATE ION, Beta-2-microglobulin, GLYCEROL | Authors: | Sala, B.M, De Rosa, M, Bolognesi, M, Ricagno, S. | Deposit date: | 2015-07-15 | Release date: | 2016-05-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability. Sci Rep, 6, 2016
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5CFH
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![BU of 5cfh by Molmil](/molmil-images/mine/5cfh) | |
4N5G
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![BU of 4n5g by Molmil](/molmil-images/mine/4n5g) | Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012 | Descriptor: | 5-(2-{(1Z)-5-fluoro-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha | Authors: | Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. | Deposit date: | 2013-10-09 | Release date: | 2014-05-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
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7RKT
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7RKR
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7RKW
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4N8R
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![BU of 4n8r by Molmil](/molmil-images/mine/4n8r) | Crystal structure of RXRa LBD complexed with a synthetic modulator K-8008 | Descriptor: | 5-(2-{(1Z)-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha | Authors: | Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. | Deposit date: | 2013-10-17 | Release date: | 2014-05-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
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4L3C
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![BU of 4l3c by Molmil](/molmil-images/mine/4l3c) | Structure of HLA-A2 in complex with D76N b2m mutant and NY-ESO1 double mutant | Descriptor: | Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ... | Authors: | Halabelian, L, Giorgetti, S, Bellotti, V, Bolognesi, M, Ricagno, S. | Deposit date: | 2013-06-05 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin. J.Biol.Chem., 289, 2014
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4L29
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![BU of 4l29 by Molmil](/molmil-images/mine/4l29) | Structure of wtMHC class I with NY-ESO1 double mutant | Descriptor: | Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ... | Authors: | Halabelian, L, Giorgetti, S, Bellotti, V, Bolognesi, M, Ricagno, S. | Deposit date: | 2013-06-04 | Release date: | 2013-12-25 | Last modified: | 2014-02-26 | Method: | X-RAY DIFFRACTION (3.09 Å) | Cite: | Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin. J.Biol.Chem., 289, 2014
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4M3K
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![BU of 4m3k by Molmil](/molmil-images/mine/4m3k) | Structure of a single domain camelid antibody fragment cAb-H7S in complex with the BlaP beta-lactamase from Bacillus licheniformis | Descriptor: | Beta-lactamase, CHLORIDE ION, Camelid heavy-chain antibody variable fragment cAb-H7S | Authors: | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | Deposit date: | 2013-08-06 | Release date: | 2014-08-06 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments To be Published
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2BJE
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![BU of 2bje by Molmil](/molmil-images/mine/2bje) | Acylphosphatase from Sulfolobus solfataricus. Monclinic P21 space group | Descriptor: | ACYLPHOSPHATASE, CHLORIDE ION, SULFATE ION | Authors: | Rosano, C, Zuccotti, S. | Deposit date: | 2005-02-02 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure, Conformational Stability, and Enzymatic Properties of Acylphosphatase from the Hyperthermophile Sulfolobus Solfataricus. Proteins: Struct., Funct., Bioinf., 62, 2006
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2BJD
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![BU of 2bjd by Molmil](/molmil-images/mine/2bjd) | Sulfolobus Solfataricus Acylphosphatase. Triclinic space group | Descriptor: | ACYLPHOSPHATASE, CADMIUM ION, CHLORIDE ION, ... | Authors: | Rosano, C, Zuccotti, S, Bolognesi, M. | Deposit date: | 2005-02-02 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Structure, Conformational Stability, and Enzymatic Properties of Acylphosphatase from the Hyperthermophile Sulfolobus Solfataricus. Proteins: Struct., Funct., Bioinf., 62, 2006
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