4L29

Structure of wtMHC class I with NY-ESO1 double mutant

Summary for 4L29
Related4L3C
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, NY-ESO1 DOUBLE MUTANT (1Y, 9V), ... (6 entities in total)
Functional Keywordsmhc, beta-2 microglobulin, hla_a0201, ny-eso1, d76n variant, immunglobulin, beta sandwitch, immune system
Biological sourceHomo sapiens (human)
More
Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted: P61769
Total number of polymer chains42
Total formula weight632864.91
Authors
Halabelian, L.,Giorgetti, S.,Bellotti, V.,Bolognesi, M.,Ricagno, S. (deposition date: 2013-06-04, release date: 2013-12-25, Last modification date: 2014-02-26)
Primary citationAchour, A.,Al-Shawi, R.,Barbiroli, A.,Bellotti, V.,Bolognesi, M.,Esposito, G.,Giorgetti, S.,Grandori, R.,Halabelian, L.,Mangione, P.P.,Marchese, L.,Pellegrino, S.,Raimondi, S.,Ricagno, S.,Santambrogio, C.,Simons, J.P.,Speck, I.,Stoppini, M.
Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
J.Biol.Chem., 289:3318-3327, 2014
PubMed: 24338476
DOI: 110.1074/jbc.M113.524157
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.09 Å)
Structure validation
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PDB entries from 2021-06-23