4L29

Structure of wtMHC class I with NY-ESO1 double mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0000139	cellular_component	Golgi membrane
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002376	biological_process	immune system process
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005765	cellular_component	lysosomal membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0010977	biological_process	negative regulation of neuron projection development
D	0012507	cellular_component	ER to Golgi transport vesicle membrane
D	0016020	cellular_component	membrane
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0023026	molecular_function	MHC class II protein complex binding
D	0030670	cellular_component	phagocytic vesicle membrane
D	0031901	cellular_component	early endosome membrane
D	0031902	cellular_component	late endosome membrane
D	0031905	cellular_component	early endosome lumen
D	0032092	biological_process	positive regulation of protein binding
D	0033077	biological_process	T cell differentiation in thymus
D	0034756	biological_process	regulation of iron ion transport
D	0035580	cellular_component	specific granule lumen
D	0042026	biological_process	protein refolding
D	0042605	molecular_function	peptide antigen binding
D	0042612	cellular_component	MHC class I protein complex
D	0042613	cellular_component	MHC class II protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0050778	biological_process	positive regulation of immune response
D	0050870	biological_process	positive regulation of T cell activation
D	0051289	biological_process	protein homotetramerization
D	0055038	cellular_component	recycling endosome membrane
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0070062	cellular_component	extracellular exosome
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1900121	biological_process	negative regulation of receptor binding
D	1900122	biological_process	positive regulation of receptor binding
D	1904434	biological_process	positive regulation of ferrous iron binding
D	1904437	biological_process	positive regulation of transferrin receptor binding
D	1904724	cellular_component	tertiary granule lumen
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation
F	0000139	cellular_component	Golgi membrane
F	0001913	biological_process	T cell mediated cytotoxicity
F	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
F	0002237	biological_process	response to molecule of bacterial origin
F	0002376	biological_process	immune system process
F	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
F	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
F	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
F	0002726	biological_process	positive regulation of T cell cytokine production
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005765	cellular_component	lysosomal membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0007608	biological_process	sensory perception of smell
F	0007611	biological_process	learning or memory
F	0009897	cellular_component	external side of plasma membrane
F	0009986	cellular_component	cell surface
F	0010977	biological_process	negative regulation of neuron projection development
F	0012507	cellular_component	ER to Golgi transport vesicle membrane
F	0016020	cellular_component	membrane
F	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
F	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
F	0023026	molecular_function	MHC class II protein complex binding
F	0030670	cellular_component	phagocytic vesicle membrane
F	0031901	cellular_component	early endosome membrane
F	0031902	cellular_component	late endosome membrane
F	0031905	cellular_component	early endosome lumen
F	0032092	biological_process	positive regulation of protein binding
F	0033077	biological_process	T cell differentiation in thymus
F	0034756	biological_process	regulation of iron ion transport
F	0035580	cellular_component	specific granule lumen
F	0042026	biological_process	protein refolding
F	0042605	molecular_function	peptide antigen binding
F	0042612	cellular_component	MHC class I protein complex
F	0042613	cellular_component	MHC class II protein complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042824	cellular_component	MHC class I peptide loading complex
F	0045646	biological_process	regulation of erythrocyte differentiation
F	0048260	biological_process	positive regulation of receptor-mediated endocytosis
F	0050680	biological_process	negative regulation of epithelial cell proliferation
F	0050768	biological_process	negative regulation of neurogenesis
F	0050778	biological_process	positive regulation of immune response
F	0050870	biological_process	positive regulation of T cell activation
F	0051289	biological_process	protein homotetramerization
F	0055038	cellular_component	recycling endosome membrane
F	0060586	biological_process	multicellular organismal-level iron ion homeostasis
F	0070062	cellular_component	extracellular exosome
F	0071281	biological_process	cellular response to iron ion
F	0071283	biological_process	cellular response to iron(III) ion
F	0071316	biological_process	cellular response to nicotine
F	1900121	biological_process	negative regulation of receptor binding
F	1900122	biological_process	positive regulation of receptor binding
F	1904434	biological_process	positive regulation of ferrous iron binding
F	1904437	biological_process	positive regulation of transferrin receptor binding
F	1904724	cellular_component	tertiary granule lumen
F	1990000	biological_process	amyloid fibril formation
F	1990712	cellular_component	HFE-transferrin receptor complex
F	2000774	biological_process	positive regulation of cellular senescence
F	2000978	biological_process	negative regulation of forebrain neuron differentiation
H	0000139	cellular_component	Golgi membrane
H	0001913	biological_process	T cell mediated cytotoxicity
H	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
H	0002237	biological_process	response to molecule of bacterial origin
H	0002376	biological_process	immune system process
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005765	cellular_component	lysosomal membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005788	cellular_component	endoplasmic reticulum lumen
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0009986	cellular_component	cell surface
H	0010977	biological_process	negative regulation of neuron projection development
H	0012507	cellular_component	ER to Golgi transport vesicle membrane
H	0016020	cellular_component	membrane
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
H	0023026	molecular_function	MHC class II protein complex binding
H	0030670	cellular_component	phagocytic vesicle membrane
H	0031901	cellular_component	early endosome membrane
H	0031902	cellular_component	late endosome membrane
H	0031905	cellular_component	early endosome lumen
H	0032092	biological_process	positive regulation of protein binding
H	0033077	biological_process	T cell differentiation in thymus
H	0034756	biological_process	regulation of iron ion transport
H	0035580	cellular_component	specific granule lumen
H	0042026	biological_process	protein refolding
H	0042605	molecular_function	peptide antigen binding
H	0042612	cellular_component	MHC class I protein complex
H	0042613	cellular_component	MHC class II protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0045646	biological_process	regulation of erythrocyte differentiation
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0050778	biological_process	positive regulation of immune response
H	0050870	biological_process	positive regulation of T cell activation
H	0051289	biological_process	protein homotetramerization
H	0055038	cellular_component	recycling endosome membrane
H	0060586	biological_process	multicellular organismal-level iron ion homeostasis
H	0070062	cellular_component	extracellular exosome
H	0071281	biological_process	cellular response to iron ion
H	0071283	biological_process	cellular response to iron(III) ion
H	0071316	biological_process	cellular response to nicotine
H	1900121	biological_process	negative regulation of receptor binding
H	1900122	biological_process	positive regulation of receptor binding
H	1904434	biological_process	positive regulation of ferrous iron binding
H	1904437	biological_process	positive regulation of transferrin receptor binding
H	1904724	cellular_component	tertiary granule lumen
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation
J	0000139	cellular_component	Golgi membrane
J	0001913	biological_process	T cell mediated cytotoxicity
J	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
J	0002237	biological_process	response to molecule of bacterial origin
J	0002376	biological_process	immune system process
J	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
J	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
J	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
J	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
J	0002726	biological_process	positive regulation of T cell cytokine production
J	0005198	molecular_function	structural molecule activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005765	cellular_component	lysosomal membrane
J	0005783	cellular_component	endoplasmic reticulum
J	0005788	cellular_component	endoplasmic reticulum lumen
J	0005794	cellular_component	Golgi apparatus
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0005925	cellular_component	focal adhesion
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006955	biological_process	immune response
J	0007608	biological_process	sensory perception of smell
J	0007611	biological_process	learning or memory
J	0009897	cellular_component	external side of plasma membrane
J	0009986	cellular_component	cell surface
J	0010977	biological_process	negative regulation of neuron projection development
J	0012507	cellular_component	ER to Golgi transport vesicle membrane
J	0016020	cellular_component	membrane
J	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
J	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
J	0023026	molecular_function	MHC class II protein complex binding
J	0030670	cellular_component	phagocytic vesicle membrane
J	0031901	cellular_component	early endosome membrane
J	0031902	cellular_component	late endosome membrane
J	0031905	cellular_component	early endosome lumen
J	0032092	biological_process	positive regulation of protein binding
J	0033077	biological_process	T cell differentiation in thymus
J	0034756	biological_process	regulation of iron ion transport
J	0035580	cellular_component	specific granule lumen
J	0042026	biological_process	protein refolding
J	0042605	molecular_function	peptide antigen binding
J	0042612	cellular_component	MHC class I protein complex
J	0042613	cellular_component	MHC class II protein complex
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0042824	cellular_component	MHC class I peptide loading complex
J	0045646	biological_process	regulation of erythrocyte differentiation
J	0048260	biological_process	positive regulation of receptor-mediated endocytosis
J	0050680	biological_process	negative regulation of epithelial cell proliferation
J	0050768	biological_process	negative regulation of neurogenesis
J	0050778	biological_process	positive regulation of immune response
J	0050870	biological_process	positive regulation of T cell activation
J	0051289	biological_process	protein homotetramerization
J	0055038	cellular_component	recycling endosome membrane
J	0060586	biological_process	multicellular organismal-level iron ion homeostasis
J	0070062	cellular_component	extracellular exosome
J	0071281	biological_process	cellular response to iron ion
J	0071283	biological_process	cellular response to iron(III) ion
J	0071316	biological_process	cellular response to nicotine
J	1900121	biological_process	negative regulation of receptor binding
J	1900122	biological_process	positive regulation of receptor binding
J	1904434	biological_process	positive regulation of ferrous iron binding
J	1904437	biological_process	positive regulation of transferrin receptor binding
J	1904724	cellular_component	tertiary granule lumen
J	1990000	biological_process	amyloid fibril formation
J	1990712	cellular_component	HFE-transferrin receptor complex
J	2000774	biological_process	positive regulation of cellular senescence
J	2000978	biological_process	negative regulation of forebrain neuron differentiation
L	0000139	cellular_component	Golgi membrane
L	0001913	biological_process	T cell mediated cytotoxicity
L	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
L	0002237	biological_process	response to molecule of bacterial origin
L	0002376	biological_process	immune system process
L	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
L	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
L	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
L	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
L	0002726	biological_process	positive regulation of T cell cytokine production
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005765	cellular_component	lysosomal membrane
L	0005783	cellular_component	endoplasmic reticulum
L	0005788	cellular_component	endoplasmic reticulum lumen
L	0005794	cellular_component	Golgi apparatus
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0005925	cellular_component	focal adhesion
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0007608	biological_process	sensory perception of smell
L	0007611	biological_process	learning or memory
L	0009897	cellular_component	external side of plasma membrane
L	0009986	cellular_component	cell surface
L	0010977	biological_process	negative regulation of neuron projection development
L	0012507	cellular_component	ER to Golgi transport vesicle membrane
L	0016020	cellular_component	membrane
L	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
L	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
L	0023026	molecular_function	MHC class II protein complex binding
L	0030670	cellular_component	phagocytic vesicle membrane
L	0031901	cellular_component	early endosome membrane
L	0031902	cellular_component	late endosome membrane
L	0031905	cellular_component	early endosome lumen
L	0032092	biological_process	positive regulation of protein binding
L	0033077	biological_process	T cell differentiation in thymus
L	0034756	biological_process	regulation of iron ion transport
L	0035580	cellular_component	specific granule lumen
L	0042026	biological_process	protein refolding
L	0042605	molecular_function	peptide antigen binding
L	0042612	cellular_component	MHC class I protein complex
L	0042613	cellular_component	MHC class II protein complex
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0042824	cellular_component	MHC class I peptide loading complex
L	0045646	biological_process	regulation of erythrocyte differentiation
L	0048260	biological_process	positive regulation of receptor-mediated endocytosis
L	0050680	biological_process	negative regulation of epithelial cell proliferation
L	0050768	biological_process	negative regulation of neurogenesis
L	0050778	biological_process	positive regulation of immune response
L	0050870	biological_process	positive regulation of T cell activation
L	0051289	biological_process	protein homotetramerization
L	0055038	cellular_component	recycling endosome membrane
L	0060586	biological_process	multicellular organismal-level iron ion homeostasis
L	0070062	cellular_component	extracellular exosome
L	0071281	biological_process	cellular response to iron ion
L	0071283	biological_process	cellular response to iron(III) ion
L	0071316	biological_process	cellular response to nicotine
L	1900121	biological_process	negative regulation of receptor binding
L	1900122	biological_process	positive regulation of receptor binding
L	1904434	biological_process	positive regulation of ferrous iron binding
L	1904437	biological_process	positive regulation of transferrin receptor binding
L	1904724	cellular_component	tertiary granule lumen
L	1990000	biological_process	amyloid fibril formation
L	1990712	cellular_component	HFE-transferrin receptor complex
L	2000774	biological_process	positive regulation of cellular senescence
L	2000978	biological_process	negative regulation of forebrain neuron differentiation
N	0000139	cellular_component	Golgi membrane
N	0001913	biological_process	T cell mediated cytotoxicity
N	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
N	0002237	biological_process	response to molecule of bacterial origin
N	0002376	biological_process	immune system process
N	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
N	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
N	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
N	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
N	0002726	biological_process	positive regulation of T cell cytokine production
N	0005198	molecular_function	structural molecule activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005765	cellular_component	lysosomal membrane
N	0005783	cellular_component	endoplasmic reticulum
N	0005788	cellular_component	endoplasmic reticulum lumen
N	0005794	cellular_component	Golgi apparatus
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0005925	cellular_component	focal adhesion
N	0006826	biological_process	iron ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006955	biological_process	immune response
N	0007608	biological_process	sensory perception of smell
N	0007611	biological_process	learning or memory
N	0009897	cellular_component	external side of plasma membrane
N	0009986	cellular_component	cell surface
N	0010977	biological_process	negative regulation of neuron projection development
N	0012507	cellular_component	ER to Golgi transport vesicle membrane
N	0016020	cellular_component	membrane
N	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
N	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
N	0023026	molecular_function	MHC class II protein complex binding
N	0030670	cellular_component	phagocytic vesicle membrane
N	0031901	cellular_component	early endosome membrane
N	0031902	cellular_component	late endosome membrane
N	0031905	cellular_component	early endosome lumen
N	0032092	biological_process	positive regulation of protein binding
N	0033077	biological_process	T cell differentiation in thymus
N	0034756	biological_process	regulation of iron ion transport
N	0035580	cellular_component	specific granule lumen
N	0042026	biological_process	protein refolding
N	0042605	molecular_function	peptide antigen binding
N	0042612	cellular_component	MHC class I protein complex
N	0042613	cellular_component	MHC class II protein complex
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0042824	cellular_component	MHC class I peptide loading complex
N	0045646	biological_process	regulation of erythrocyte differentiation
N	0048260	biological_process	positive regulation of receptor-mediated endocytosis
N	0050680	biological_process	negative regulation of epithelial cell proliferation
N	0050768	biological_process	negative regulation of neurogenesis
N	0050778	biological_process	positive regulation of immune response
N	0050870	biological_process	positive regulation of T cell activation
N	0051289	biological_process	protein homotetramerization
N	0055038	cellular_component	recycling endosome membrane
N	0060586	biological_process	multicellular organismal-level iron ion homeostasis
N	0070062	cellular_component	extracellular exosome
N	0071281	biological_process	cellular response to iron ion
N	0071283	biological_process	cellular response to iron(III) ion
N	0071316	biological_process	cellular response to nicotine
N	1900121	biological_process	negative regulation of receptor binding
N	1900122	biological_process	positive regulation of receptor binding
N	1904434	biological_process	positive regulation of ferrous iron binding
N	1904437	biological_process	positive regulation of transferrin receptor binding
N	1904724	cellular_component	tertiary granule lumen
N	1990000	biological_process	amyloid fibril formation
N	1990712	cellular_component	HFE-transferrin receptor complex
N	2000774	biological_process	positive regulation of cellular senescence
N	2000978	biological_process	negative regulation of forebrain neuron differentiation
P	0000139	cellular_component	Golgi membrane
P	0001913	biological_process	T cell mediated cytotoxicity
P	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
P	0002237	biological_process	response to molecule of bacterial origin
P	0002376	biological_process	immune system process
P	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
P	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
P	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
P	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
P	0002726	biological_process	positive regulation of T cell cytokine production
P	0005198	molecular_function	structural molecule activity
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005765	cellular_component	lysosomal membrane
P	0005783	cellular_component	endoplasmic reticulum
P	0005788	cellular_component	endoplasmic reticulum lumen
P	0005794	cellular_component	Golgi apparatus
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0005925	cellular_component	focal adhesion
P	0006826	biological_process	iron ion transport
P	0006879	biological_process	intracellular iron ion homeostasis
P	0006955	biological_process	immune response
P	0007608	biological_process	sensory perception of smell
P	0007611	biological_process	learning or memory
P	0009897	cellular_component	external side of plasma membrane
P	0009986	cellular_component	cell surface
P	0010977	biological_process	negative regulation of neuron projection development
P	0012507	cellular_component	ER to Golgi transport vesicle membrane
P	0016020	cellular_component	membrane
P	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
P	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
P	0023026	molecular_function	MHC class II protein complex binding
P	0030670	cellular_component	phagocytic vesicle membrane
P	0031901	cellular_component	early endosome membrane
P	0031902	cellular_component	late endosome membrane
P	0031905	cellular_component	early endosome lumen
P	0032092	biological_process	positive regulation of protein binding
P	0033077	biological_process	T cell differentiation in thymus
P	0034756	biological_process	regulation of iron ion transport
P	0035580	cellular_component	specific granule lumen
P	0042026	biological_process	protein refolding
P	0042605	molecular_function	peptide antigen binding
P	0042612	cellular_component	MHC class I protein complex
P	0042613	cellular_component	MHC class II protein complex
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0042824	cellular_component	MHC class I peptide loading complex
P	0045646	biological_process	regulation of erythrocyte differentiation
P	0048260	biological_process	positive regulation of receptor-mediated endocytosis
P	0050680	biological_process	negative regulation of epithelial cell proliferation
P	0050768	biological_process	negative regulation of neurogenesis
P	0050778	biological_process	positive regulation of immune response
P	0050870	biological_process	positive regulation of T cell activation
P	0051289	biological_process	protein homotetramerization
P	0055038	cellular_component	recycling endosome membrane
P	0060586	biological_process	multicellular organismal-level iron ion homeostasis
P	0070062	cellular_component	extracellular exosome
P	0071281	biological_process	cellular response to iron ion
P	0071283	biological_process	cellular response to iron(III) ion
P	0071316	biological_process	cellular response to nicotine
P	1900121	biological_process	negative regulation of receptor binding
P	1900122	biological_process	positive regulation of receptor binding
P	1904434	biological_process	positive regulation of ferrous iron binding
P	1904437	biological_process	positive regulation of transferrin receptor binding
P	1904724	cellular_component	tertiary granule lumen
P	1990000	biological_process	amyloid fibril formation
P	1990712	cellular_component	HFE-transferrin receptor complex
P	2000774	biological_process	positive regulation of cellular senescence
P	2000978	biological_process	negative regulation of forebrain neuron differentiation
R	0000139	cellular_component	Golgi membrane
R	0001913	biological_process	T cell mediated cytotoxicity
R	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
R	0002237	biological_process	response to molecule of bacterial origin
R	0002376	biological_process	immune system process
R	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
R	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
R	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
R	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
R	0002726	biological_process	positive regulation of T cell cytokine production
R	0005198	molecular_function	structural molecule activity
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005615	cellular_component	extracellular space
R	0005765	cellular_component	lysosomal membrane
R	0005783	cellular_component	endoplasmic reticulum
R	0005788	cellular_component	endoplasmic reticulum lumen
R	0005794	cellular_component	Golgi apparatus
R	0005829	cellular_component	cytosol
R	0005886	cellular_component	plasma membrane
R	0005925	cellular_component	focal adhesion
R	0006826	biological_process	iron ion transport
R	0006879	biological_process	intracellular iron ion homeostasis
R	0006955	biological_process	immune response
R	0007608	biological_process	sensory perception of smell
R	0007611	biological_process	learning or memory
R	0009897	cellular_component	external side of plasma membrane
R	0009986	cellular_component	cell surface
R	0010977	biological_process	negative regulation of neuron projection development
R	0012507	cellular_component	ER to Golgi transport vesicle membrane
R	0016020	cellular_component	membrane
R	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
R	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
R	0023026	molecular_function	MHC class II protein complex binding
R	0030670	cellular_component	phagocytic vesicle membrane
R	0031901	cellular_component	early endosome membrane
R	0031902	cellular_component	late endosome membrane
R	0031905	cellular_component	early endosome lumen
R	0032092	biological_process	positive regulation of protein binding
R	0033077	biological_process	T cell differentiation in thymus
R	0034756	biological_process	regulation of iron ion transport
R	0035580	cellular_component	specific granule lumen
R	0042026	biological_process	protein refolding
R	0042605	molecular_function	peptide antigen binding
R	0042612	cellular_component	MHC class I protein complex
R	0042613	cellular_component	MHC class II protein complex
R	0042802	molecular_function	identical protein binding
R	0042803	molecular_function	protein homodimerization activity
R	0042824	cellular_component	MHC class I peptide loading complex
R	0045646	biological_process	regulation of erythrocyte differentiation
R	0048260	biological_process	positive regulation of receptor-mediated endocytosis
R	0050680	biological_process	negative regulation of epithelial cell proliferation
R	0050768	biological_process	negative regulation of neurogenesis
R	0050778	biological_process	positive regulation of immune response
R	0050870	biological_process	positive regulation of T cell activation
R	0051289	biological_process	protein homotetramerization
R	0055038	cellular_component	recycling endosome membrane
R	0060586	biological_process	multicellular organismal-level iron ion homeostasis
R	0070062	cellular_component	extracellular exosome
R	0071281	biological_process	cellular response to iron ion
R	0071283	biological_process	cellular response to iron(III) ion
R	0071316	biological_process	cellular response to nicotine
R	1900121	biological_process	negative regulation of receptor binding
R	1900122	biological_process	positive regulation of receptor binding
R	1904434	biological_process	positive regulation of ferrous iron binding
R	1904437	biological_process	positive regulation of transferrin receptor binding
R	1904724	cellular_component	tertiary granule lumen
R	1990000	biological_process	amyloid fibril formation
R	1990712	cellular_component	HFE-transferrin receptor complex
R	2000774	biological_process	positive regulation of cellular senescence
R	2000978	biological_process	negative regulation of forebrain neuron differentiation
T	0000139	cellular_component	Golgi membrane
T	0001913	biological_process	T cell mediated cytotoxicity
T	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
T	0002237	biological_process	response to molecule of bacterial origin
T	0002376	biological_process	immune system process
T	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
T	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
T	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
T	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
T	0002726	biological_process	positive regulation of T cell cytokine production
T	0005198	molecular_function	structural molecule activity
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0005765	cellular_component	lysosomal membrane
T	0005783	cellular_component	endoplasmic reticulum
T	0005788	cellular_component	endoplasmic reticulum lumen
T	0005794	cellular_component	Golgi apparatus
T	0005829	cellular_component	cytosol
T	0005886	cellular_component	plasma membrane
T	0005925	cellular_component	focal adhesion
T	0006826	biological_process	iron ion transport
T	0006879	biological_process	intracellular iron ion homeostasis
T	0006955	biological_process	immune response
T	0007608	biological_process	sensory perception of smell
T	0007611	biological_process	learning or memory
T	0009897	cellular_component	external side of plasma membrane
T	0009986	cellular_component	cell surface
T	0010977	biological_process	negative regulation of neuron projection development
T	0012507	cellular_component	ER to Golgi transport vesicle membrane
T	0016020	cellular_component	membrane
T	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
T	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
T	0023026	molecular_function	MHC class II protein complex binding
T	0030670	cellular_component	phagocytic vesicle membrane
T	0031901	cellular_component	early endosome membrane
T	0031902	cellular_component	late endosome membrane
T	0031905	cellular_component	early endosome lumen
T	0032092	biological_process	positive regulation of protein binding
T	0033077	biological_process	T cell differentiation in thymus
T	0034756	biological_process	regulation of iron ion transport
T	0035580	cellular_component	specific granule lumen
T	0042026	biological_process	protein refolding
T	0042605	molecular_function	peptide antigen binding
T	0042612	cellular_component	MHC class I protein complex
T	0042613	cellular_component	MHC class II protein complex
T	0042802	molecular_function	identical protein binding
T	0042803	molecular_function	protein homodimerization activity
T	0042824	cellular_component	MHC class I peptide loading complex
T	0045646	biological_process	regulation of erythrocyte differentiation
T	0048260	biological_process	positive regulation of receptor-mediated endocytosis
T	0050680	biological_process	negative regulation of epithelial cell proliferation
T	0050768	biological_process	negative regulation of neurogenesis
T	0050778	biological_process	positive regulation of immune response
T	0050870	biological_process	positive regulation of T cell activation
T	0051289	biological_process	protein homotetramerization
T	0055038	cellular_component	recycling endosome membrane
T	0060586	biological_process	multicellular organismal-level iron ion homeostasis
T	0070062	cellular_component	extracellular exosome
T	0071281	biological_process	cellular response to iron ion
T	0071283	biological_process	cellular response to iron(III) ion
T	0071316	biological_process	cellular response to nicotine
T	1900121	biological_process	negative regulation of receptor binding
T	1900122	biological_process	positive regulation of receptor binding
T	1904434	biological_process	positive regulation of ferrous iron binding
T	1904437	biological_process	positive regulation of transferrin receptor binding
T	1904724	cellular_component	tertiary granule lumen
T	1990000	biological_process	amyloid fibril formation
T	1990712	cellular_component	HFE-transferrin receptor complex
T	2000774	biological_process	positive regulation of cellular senescence
T	2000978	biological_process	negative regulation of forebrain neuron differentiation
V	0000139	cellular_component	Golgi membrane
V	0001913	biological_process	T cell mediated cytotoxicity
V	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
V	0002237	biological_process	response to molecule of bacterial origin
V	0002376	biological_process	immune system process
V	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
V	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
V	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
V	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
V	0002726	biological_process	positive regulation of T cell cytokine production
V	0005198	molecular_function	structural molecule activity
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005615	cellular_component	extracellular space
V	0005765	cellular_component	lysosomal membrane
V	0005783	cellular_component	endoplasmic reticulum
V	0005788	cellular_component	endoplasmic reticulum lumen
V	0005794	cellular_component	Golgi apparatus
V	0005829	cellular_component	cytosol
V	0005886	cellular_component	plasma membrane
V	0005925	cellular_component	focal adhesion
V	0006826	biological_process	iron ion transport
V	0006879	biological_process	intracellular iron ion homeostasis
V	0006955	biological_process	immune response
V	0007608	biological_process	sensory perception of smell
V	0007611	biological_process	learning or memory
V	0009897	cellular_component	external side of plasma membrane
V	0009986	cellular_component	cell surface
V	0010977	biological_process	negative regulation of neuron projection development
V	0012507	cellular_component	ER to Golgi transport vesicle membrane
V	0016020	cellular_component	membrane
V	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
V	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
V	0023026	molecular_function	MHC class II protein complex binding
V	0030670	cellular_component	phagocytic vesicle membrane
V	0031901	cellular_component	early endosome membrane
V	0031902	cellular_component	late endosome membrane
V	0031905	cellular_component	early endosome lumen
V	0032092	biological_process	positive regulation of protein binding
V	0033077	biological_process	T cell differentiation in thymus
V	0034756	biological_process	regulation of iron ion transport
V	0035580	cellular_component	specific granule lumen
V	0042026	biological_process	protein refolding
V	0042605	molecular_function	peptide antigen binding
V	0042612	cellular_component	MHC class I protein complex
V	0042613	cellular_component	MHC class II protein complex
V	0042802	molecular_function	identical protein binding
V	0042803	molecular_function	protein homodimerization activity
V	0042824	cellular_component	MHC class I peptide loading complex
V	0045646	biological_process	regulation of erythrocyte differentiation
V	0048260	biological_process	positive regulation of receptor-mediated endocytosis
V	0050680	biological_process	negative regulation of epithelial cell proliferation
V	0050768	biological_process	negative regulation of neurogenesis
V	0050778	biological_process	positive regulation of immune response
V	0050870	biological_process	positive regulation of T cell activation
V	0051289	biological_process	protein homotetramerization
V	0055038	cellular_component	recycling endosome membrane
V	0060586	biological_process	multicellular organismal-level iron ion homeostasis
V	0070062	cellular_component	extracellular exosome
V	0071281	biological_process	cellular response to iron ion
V	0071283	biological_process	cellular response to iron(III) ion
V	0071316	biological_process	cellular response to nicotine
V	1900121	biological_process	negative regulation of receptor binding
V	1900122	biological_process	positive regulation of receptor binding
V	1904434	biological_process	positive regulation of ferrous iron binding
V	1904437	biological_process	positive regulation of transferrin receptor binding
V	1904724	cellular_component	tertiary granule lumen
V	1990000	biological_process	amyloid fibril formation
V	1990712	cellular_component	HFE-transferrin receptor complex
V	2000774	biological_process	positive regulation of cellular senescence
V	2000978	biological_process	negative regulation of forebrain neuron differentiation
X	0000139	cellular_component	Golgi membrane
X	0001913	biological_process	T cell mediated cytotoxicity
X	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
X	0002237	biological_process	response to molecule of bacterial origin
X	0002376	biological_process	immune system process
X	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
X	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
X	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
X	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
X	0002726	biological_process	positive regulation of T cell cytokine production
X	0005198	molecular_function	structural molecule activity
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005615	cellular_component	extracellular space
X	0005765	cellular_component	lysosomal membrane
X	0005783	cellular_component	endoplasmic reticulum
X	0005788	cellular_component	endoplasmic reticulum lumen
X	0005794	cellular_component	Golgi apparatus
X	0005829	cellular_component	cytosol
X	0005886	cellular_component	plasma membrane
X	0005925	cellular_component	focal adhesion
X	0006826	biological_process	iron ion transport
X	0006879	biological_process	intracellular iron ion homeostasis
X	0006955	biological_process	immune response
X	0007608	biological_process	sensory perception of smell
X	0007611	biological_process	learning or memory
X	0009897	cellular_component	external side of plasma membrane
X	0009986	cellular_component	cell surface
X	0010977	biological_process	negative regulation of neuron projection development
X	0012507	cellular_component	ER to Golgi transport vesicle membrane
X	0016020	cellular_component	membrane
X	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
X	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
X	0023026	molecular_function	MHC class II protein complex binding
X	0030670	cellular_component	phagocytic vesicle membrane
X	0031901	cellular_component	early endosome membrane
X	0031902	cellular_component	late endosome membrane
X	0031905	cellular_component	early endosome lumen
X	0032092	biological_process	positive regulation of protein binding
X	0033077	biological_process	T cell differentiation in thymus
X	0034756	biological_process	regulation of iron ion transport
X	0035580	cellular_component	specific granule lumen
X	0042026	biological_process	protein refolding
X	0042605	molecular_function	peptide antigen binding
X	0042612	cellular_component	MHC class I protein complex
X	0042613	cellular_component	MHC class II protein complex
X	0042802	molecular_function	identical protein binding
X	0042803	molecular_function	protein homodimerization activity
X	0042824	cellular_component	MHC class I peptide loading complex
X	0045646	biological_process	regulation of erythrocyte differentiation
X	0048260	biological_process	positive regulation of receptor-mediated endocytosis
X	0050680	biological_process	negative regulation of epithelial cell proliferation
X	0050768	biological_process	negative regulation of neurogenesis
X	0050778	biological_process	positive regulation of immune response
X	0050870	biological_process	positive regulation of T cell activation
X	0051289	biological_process	protein homotetramerization
X	0055038	cellular_component	recycling endosome membrane
X	0060586	biological_process	multicellular organismal-level iron ion homeostasis
X	0070062	cellular_component	extracellular exosome
X	0071281	biological_process	cellular response to iron ion
X	0071283	biological_process	cellular response to iron(III) ion
X	0071316	biological_process	cellular response to nicotine
X	1900121	biological_process	negative regulation of receptor binding
X	1900122	biological_process	positive regulation of receptor binding
X	1904434	biological_process	positive regulation of ferrous iron binding
X	1904437	biological_process	positive regulation of transferrin receptor binding
X	1904724	cellular_component	tertiary granule lumen
X	1990000	biological_process	amyloid fibril formation
X	1990712	cellular_component	HFE-transferrin receptor complex
X	2000774	biological_process	positive regulation of cellular senescence
X	2000978	biological_process	negative regulation of forebrain neuron differentiation
Z	0000139	cellular_component	Golgi membrane
Z	0001913	biological_process	T cell mediated cytotoxicity
Z	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
Z	0002237	biological_process	response to molecule of bacterial origin
Z	0002376	biological_process	immune system process
Z	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
Z	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
Z	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
Z	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
Z	0002726	biological_process	positive regulation of T cell cytokine production
Z	0005198	molecular_function	structural molecule activity
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005615	cellular_component	extracellular space
Z	0005765	cellular_component	lysosomal membrane
Z	0005783	cellular_component	endoplasmic reticulum
Z	0005788	cellular_component	endoplasmic reticulum lumen
Z	0005794	cellular_component	Golgi apparatus
Z	0005829	cellular_component	cytosol
Z	0005886	cellular_component	plasma membrane
Z	0005925	cellular_component	focal adhesion
Z	0006826	biological_process	iron ion transport
Z	0006879	biological_process	intracellular iron ion homeostasis
Z	0006955	biological_process	immune response
Z	0007608	biological_process	sensory perception of smell
Z	0007611	biological_process	learning or memory
Z	0009897	cellular_component	external side of plasma membrane
Z	0009986	cellular_component	cell surface
Z	0010977	biological_process	negative regulation of neuron projection development
Z	0012507	cellular_component	ER to Golgi transport vesicle membrane
Z	0016020	cellular_component	membrane
Z	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
Z	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
Z	0023026	molecular_function	MHC class II protein complex binding
Z	0030670	cellular_component	phagocytic vesicle membrane
Z	0031901	cellular_component	early endosome membrane
Z	0031902	cellular_component	late endosome membrane
Z	0031905	cellular_component	early endosome lumen
Z	0032092	biological_process	positive regulation of protein binding
Z	0033077	biological_process	T cell differentiation in thymus
Z	0034756	biological_process	regulation of iron ion transport
Z	0035580	cellular_component	specific granule lumen
Z	0042026	biological_process	protein refolding
Z	0042605	molecular_function	peptide antigen binding
Z	0042612	cellular_component	MHC class I protein complex
Z	0042613	cellular_component	MHC class II protein complex
Z	0042802	molecular_function	identical protein binding
Z	0042803	molecular_function	protein homodimerization activity
Z	0042824	cellular_component	MHC class I peptide loading complex
Z	0045646	biological_process	regulation of erythrocyte differentiation
Z	0048260	biological_process	positive regulation of receptor-mediated endocytosis
Z	0050680	biological_process	negative regulation of epithelial cell proliferation
Z	0050768	biological_process	negative regulation of neurogenesis
Z	0050778	biological_process	positive regulation of immune response
Z	0050870	biological_process	positive regulation of T cell activation
Z	0051289	biological_process	protein homotetramerization
Z	0055038	cellular_component	recycling endosome membrane
Z	0060586	biological_process	multicellular organismal-level iron ion homeostasis
Z	0070062	cellular_component	extracellular exosome
Z	0071281	biological_process	cellular response to iron ion
Z	0071283	biological_process	cellular response to iron(III) ion
Z	0071316	biological_process	cellular response to nicotine
Z	1900121	biological_process	negative regulation of receptor binding
Z	1900122	biological_process	positive regulation of receptor binding
Z	1904434	biological_process	positive regulation of ferrous iron binding
Z	1904437	biological_process	positive regulation of transferrin receptor binding
Z	1904724	cellular_component	tertiary granule lumen
Z	1990000	biological_process	amyloid fibril formation
Z	1990712	cellular_component	HFE-transferrin receptor complex
Z	2000774	biological_process	positive regulation of cellular senescence
Z	2000978	biological_process	negative regulation of forebrain neuron differentiation
b	0000139	cellular_component	Golgi membrane
b	0001913	biological_process	T cell mediated cytotoxicity
b	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
b	0002237	biological_process	response to molecule of bacterial origin
b	0002376	biological_process	immune system process
b	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
b	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
b	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
b	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
b	0002726	biological_process	positive regulation of T cell cytokine production
b	0005198	molecular_function	structural molecule activity
b	0005515	molecular_function	protein binding
b	0005576	cellular_component	extracellular region
b	0005615	cellular_component	extracellular space
b	0005765	cellular_component	lysosomal membrane
b	0005783	cellular_component	endoplasmic reticulum
b	0005788	cellular_component	endoplasmic reticulum lumen
b	0005794	cellular_component	Golgi apparatus
b	0005829	cellular_component	cytosol
b	0005886	cellular_component	plasma membrane
b	0005925	cellular_component	focal adhesion
b	0006826	biological_process	iron ion transport
b	0006879	biological_process	intracellular iron ion homeostasis
b	0006955	biological_process	immune response
b	0007608	biological_process	sensory perception of smell
b	0007611	biological_process	learning or memory
b	0009897	cellular_component	external side of plasma membrane
b	0009986	cellular_component	cell surface
b	0010977	biological_process	negative regulation of neuron projection development
b	0012507	cellular_component	ER to Golgi transport vesicle membrane
b	0016020	cellular_component	membrane
b	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
b	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
b	0023026	molecular_function	MHC class II protein complex binding
b	0030670	cellular_component	phagocytic vesicle membrane
b	0031901	cellular_component	early endosome membrane
b	0031902	cellular_component	late endosome membrane
b	0031905	cellular_component	early endosome lumen
b	0032092	biological_process	positive regulation of protein binding
b	0033077	biological_process	T cell differentiation in thymus
b	0034756	biological_process	regulation of iron ion transport
b	0035580	cellular_component	specific granule lumen
b	0042026	biological_process	protein refolding
b	0042605	molecular_function	peptide antigen binding
b	0042612	cellular_component	MHC class I protein complex
b	0042613	cellular_component	MHC class II protein complex
b	0042802	molecular_function	identical protein binding
b	0042803	molecular_function	protein homodimerization activity
b	0042824	cellular_component	MHC class I peptide loading complex
b	0045646	biological_process	regulation of erythrocyte differentiation
b	0048260	biological_process	positive regulation of receptor-mediated endocytosis
b	0050680	biological_process	negative regulation of epithelial cell proliferation
b	0050768	biological_process	negative regulation of neurogenesis
b	0050778	biological_process	positive regulation of immune response
b	0050870	biological_process	positive regulation of T cell activation
b	0051289	biological_process	protein homotetramerization
b	0055038	cellular_component	recycling endosome membrane
b	0060586	biological_process	multicellular organismal-level iron ion homeostasis
b	0070062	cellular_component	extracellular exosome
b	0071281	biological_process	cellular response to iron ion
b	0071283	biological_process	cellular response to iron(III) ion
b	0071316	biological_process	cellular response to nicotine
b	1900121	biological_process	negative regulation of receptor binding
b	1900122	biological_process	positive regulation of receptor binding
b	1904434	biological_process	positive regulation of ferrous iron binding
b	1904437	biological_process	positive regulation of transferrin receptor binding
b	1904724	cellular_component	tertiary granule lumen
b	1990000	biological_process	amyloid fibril formation
b	1990712	cellular_component	HFE-transferrin receptor complex
b	2000774	biological_process	positive regulation of cellular senescence
b	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 301

Chain	Residue
A	ARG21

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 302

Chain	Residue
A	ARG97
A	HIS114
A	TRP147
A	VAL152
A	LEU156
m	TRP5
m	ILE6
m	THR7

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 101

Chain	Residue
B	TYR78

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 301

Chain	Residue
C	ARG21

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 302

Chain	Residue
C	ARG97
C	VAL152
C	LEU156
i	TRP5
i	THR7

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL C 303

Chain	Residue
C	ARG35
C	ALA41

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL i 101

Chain	Residue
C	ARG65
K	MET189
i	MET4

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 301

Chain	Residue
E	ARG21
F	HIS51

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL E 302

Chain	Residue
E	ARG97
E	TRP147
E	VAL152
E	LEU156
k	TRP5
k	ILE6
k	THR7

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL F 101

Chain	Residue
F	LYS41
F	TYR78

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL G 301

Chain	Residue
G	ARG21

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL H 101

Chain	Residue
H	THR71

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL f 101

Chain	Residue
G	ARG97
G	VAL152
f	TRP5
f	THR7

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL I 301

Chain	Residue
I	ARG21

---

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL I 302

Chain	Residue
I	LYS144

---

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL I 303

Chain	Residue
I	ARG111

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL J 101

Chain	Residue
J	LYS41
J	PHE70
J	THR71
J	TYR78

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL l 101

Chain	Residue
I	ARG97
I	TRP147
I	VAL152
I	LEU156
l	ILE6
l	THR7

---

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL K 302

Chain	Residue
K	ARG35
K	ALA41

---

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL L 101

Chain	Residue
L	THR71

---

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL h 101

Chain	Residue
K	ARG97
K	VAL152
K	LEU156
h	LEU3
h	TRP5
h	THR7

---

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL N 101

Chain	Residue
N	LYS41
N	THR71

---

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL N 102

Chain	Residue
N	HIS51

---

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL e 101

Chain	Residue
M	ARG97
M	TRP147
M	VAL152
M	LEU156
e	TRP5
e	THR7

---

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL O 301

Chain	Residue
O	ARG21

---

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL O 302

Chain	Residue
O	ARG97
O	HIS114
O	TRP147
O	VAL152
O	LEU156
n	THR7

---

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL O 303

Chain	Residue
O	ALA40
O	ALA41

---

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL P 101

Chain	Residue
P	THR71

---

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL Q 301

Chain	Residue
C	ARG131
Q	PHE109

---

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL Q 303

Chain	Residue
Q	ARG97
Q	TRP147
Q	VAL152
Q	LEU156
p	THR7

---

site_id	DC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL R 101

Chain	Residue
R	THR71

---

site_id	DC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL S 301

Chain	Residue
S	ARG21

---

site_id	DC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL S 302

Chain	Residue
S	ASP37

---

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL T 101

Chain	Residue
T	LYS41
T	THR71
T	TYR78

---

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL o 101

Chain	Residue
S	ARG97
S	HIS114
S	GLN155
S	LEU156
o	LEU3
o	THR7

---

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL V 101

Chain	Residue
V	TYR78
V	LYS41

---

site_id	EC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL c 101

Chain	Residue
U	ARG97
U	HIS114
U	TRP147
U	VAL152
U	LEU156
c	LEU3
c	ILE6
c	THR7

---

site_id	EC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL W 301

Chain	Residue
W	ARG21

---

site_id	EC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL g 101

Chain	Residue
W	ARG97
W	TRP147
W	VAL152
W	LEU156
g	LEU3
g	TRP5
g	THR7

---

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL Y 301

Chain	Residue
Y	ARG21
Z	HIS51

---

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL Y 302

Chain	Residue
Y	ARG35
Y	ASP37
Y	ALA41

---

site_id	EC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL q 101

Chain	Residue
Y	ARG97
Y	VAL152
Y	LEU156
q	LEU3
q	TRP5
q	THR7

---

site_id	EC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL a 301

Chain	Residue
b	HIS51

---

site_id	EC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL a 302

Chain	Residue
a	ARG97
a	VAL152
a	LEU156
j	TRP5
j	THR7

---

site_id	EC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL b 101

Chain	Residue
b	LYS41
b	TYR78

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR257-HIS263

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280

Chain	Residue	Details
B	GLN2
T	GLN2
V	GLN2
X	GLN2
Z	GLN2
b	GLN2
E	TYR84
E	THR143
E	LYS146
E	TYR171
G	TYR7
D	GLN2
G	THR73
G	TYR84
G	THR143
G	LYS146
G	TYR171
I	TYR7
I	THR73
I	TYR84
I	THR143
I	LYS146
F	GLN2
I	TYR171
K	TYR7
K	THR73
K	TYR84
K	THR143
K	LYS146
K	TYR171
M	TYR7
M	THR73
M	TYR84
H	GLN2
M	THR143
M	LYS146
M	TYR171
O	TYR7
O	THR73
O	TYR84
O	THR143
O	LYS146
O	TYR171
Q	TYR7
J	GLN2
Q	THR73
Q	TYR84
Q	THR143
Q	LYS146
Q	TYR171
S	TYR7
S	THR73
S	TYR84
S	THR143
S	LYS146
L	GLN2
S	TYR171
U	TYR7
U	THR73
U	TYR84
U	THR143
U	LYS146
U	TYR171
W	TYR7
W	THR73
W	TYR84
N	GLN2
W	THR143
W	LYS146
W	TYR171
Y	TYR7
Y	THR73
Y	TYR84
Y	THR143
Y	LYS146
Y	TYR171
a	TYR7
P	GLN2
a	THR73
a	TYR84
a	THR143
a	LYS146
a	TYR171
R	GLN2

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443

Chain	Residue	Details
B	ILE1
T	ILE1
V	ILE1
X	ILE1
Z	ILE1
b	ILE1
O	TYR116
O	TYR159
Q	TYR116
Q	TYR159
S	TYR116
D	ILE1
S	TYR159
U	TYR116
U	TYR159
W	TYR116
W	TYR159
Y	TYR116
Y	TYR159
a	TYR116
a	TYR159
F	ILE1
H	ILE1
J	ILE1
L	ILE1
N	ILE1
P	ILE1
R	ILE1

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443

Chain	Residue	Details
B	LYS19
D	LYS58
D	LYS91
D	LYS94
F	LYS19
F	LYS41
F	LYS48
F	LYS58
F	LYS91
F	LYS94
H	LYS19
B	LYS41
H	LYS41
H	LYS48
H	LYS58
H	LYS91
H	LYS94
J	LYS19
J	LYS41
J	LYS48
J	LYS58
J	LYS91
B	LYS48
J	LYS94
L	LYS19
L	LYS41
L	LYS48
L	LYS58
L	LYS91
L	LYS94
N	LYS19
N	LYS41
N	LYS48
B	LYS58
N	LYS58
N	LYS91
N	LYS94
P	LYS19
P	LYS41
P	LYS48
P	LYS58
P	LYS91
P	LYS94
R	LYS19
B	LYS91
R	LYS41
R	LYS48
R	LYS58
R	LYS91
R	LYS94
T	LYS19
T	LYS41
T	LYS48
T	LYS58
T	LYS91
B	LYS94
T	LYS94
V	LYS19
V	LYS41
V	LYS48
V	LYS58
V	LYS91
V	LYS94
X	LYS19
X	LYS41
X	LYS48
D	LYS19
X	LYS58
X	LYS91
X	LYS94
Z	LYS19
Z	LYS41
Z	LYS48
Z	LYS58
Z	LYS91
Z	LYS94
b	LYS19
D	LYS41
b	LYS41
b	LYS48
b	LYS58
b	LYS91
b	LYS94
D	LYS48

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN86
S	ASN86
U	ASN86
W	ASN86
Y	ASN86
a	ASN86
C	ASN86
E	ASN86
G	ASN86
I	ASN86
K	ASN86
M	ASN86
O	ASN86
Q	ASN86

---