4L3C

Structure of HLA-A2 in complex with D76N b2m mutant and NY-ESO1 double mutant

Summary for 4L3C

Entry DOI	10.2210/pdb4l3c/pdb
Related	4L29
Descriptor	HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, NY-ESO1 double mutant (1Y, 9V), ... (6 entities in total)
Functional Keywords	mhc, beta-2 microglobulin, hla_a0201, ny-eso1, d76n variant, immunglobulin, beta sandwitch, immune system, amyloid aggregation
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P01892 Secreted: P61769
Total number of polymer chains	42
Total formula weight	633134.76
Authors	Halabelian, L.,Giorgetti, S.,Bellotti, V.,Bolognesi, M.,Ricagno, S. (deposition date: 2013-06-05, release date: 2013-12-25, Last modification date: 2023-09-20)
Primary citation	Halabelian, L.,Ricagno, S.,Giorgetti, S.,Santambrogio, C.,Barbiroli, A.,Pellegrino, S.,Achour, A.,Grandori, R.,Marchese, L.,Raimondi, S.,Mangione, P.P.,Esposito, G.,Al-Shawi, R.,Simons, J.P.,Speck, I.,Stoppini, M.,Bolognesi, M.,Bellotti, V. Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin. J.Biol.Chem., 289:3318-3327, 2014 Cited by PubMed: 24338476 DOI: 10.1074/jbc.M113.524157 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.64 Å)

Structure validation