4L3C
Structure of HLA-A2 in complex with D76N b2m mutant and NY-ESO1 double mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, BA, D, EA, G... (A, C, E, G, I...) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31951.3 | 14 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (human) | MHC class I antigen A*2 |
| 2 | B, CA, E, FA, H... (B, D, F, H, J...) | Beta-2-microglobulin | polymer | 100 | 11878.4 | 14 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
| 3 | AA, C, DA, F, GA... (m, i, k, f, l...) | NY-ESO1 double mutant (1Y, 9V) | polymer | 9 | 1166.4 | 14 | |||
| 4 | AB, AC, BB, BC, CC... (E, Q, F, R, G...) | CHLORIDE ION | non-polymer | 35.5 | 38 | Chemie (CL) PubChem (312) | |||
| 5 | CB, DC, FB, FC, GC... (k, p, f, S, U...) | GLYCEROL | non-polymer | 92.1 | 20 | Chemie (GOL) PubChem (753) | |||
| 6 | AD, BD, CD, DD, ED... (E, F, G, H, I...) | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence modifications
B, D, F, H, J, L, N, P, R, T, V, X, Z, b: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Asn 76 | Asp 96 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 42 |
| Total formula weight | 629945.7 | |
| Non-Polymers* | Number of molecules | 58 |
| Total formula weight | 3189.1 | |
| All* | Total formula weight | 633134.8 |
