8R4D

Focused map on the Roc-COR domains of the Roco protein from C. tepidum in the GTP state bound to the activating Nanobody NbRoco1

Summary for 8R4D

• Entry DOI: 10.2210/pdb8r4d/pdb
• Related: 8R4B 8R4C
• EMDB information: 18886
• Descriptor: Rab family protein, NbRoco1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE (3 entities in total)
• Functional Keywords: gtpase, nanobody, parkinson's disease, allostery activator, hydrolase
• Biological source: Chlorobaculum tepidum; More
• Total number of polymer chains: 2
• Total formula weight: 140059.42

Authors

Galicia, C.,Versees, W. (deposition date: 2023-11-13, release date: 2024-05-01, Last modification date: 2024-05-15)

• Primary citation: Galicia, C.,Guaitoli, G.,Fislage, M.,Gloeckner, C.J.,Versees, W.; Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies.; Elife, 13:-, 2024; PubMed: 38666771; DOI: 10.7554/eLife.94503

Experimental method

ELECTRON MICROSCOPY (3.88 Å)