4JWG
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![BU of 4jwg by Molmil](/molmil-images/mine/4jwg) | Crystal structure of spTrm10(74) | Descriptor: | ACETIC ACID, tRNA (guanine(9)-N1)-methyltransferase | Authors: | Yan, W, Shao, Z. | Deposit date: | 2013-03-27 | Release date: | 2013-10-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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4JWF
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![BU of 4jwf by Molmil](/molmil-images/mine/4jwf) | Crystal structure of spTrm10(74)-SAH complex | Descriptor: | ACETIC ACID, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase | Authors: | Yan, W, Shao, Z. | Deposit date: | 2013-03-27 | Release date: | 2013-10-16 | Last modified: | 2014-02-12 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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4JWH
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![BU of 4jwh by Molmil](/molmil-images/mine/4jwh) | Crystal structure of spTrm10(Full length)-SAH complex | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase | Authors: | Yan, W, Shao, Z. | Deposit date: | 2013-03-27 | Release date: | 2013-10-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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8FZB
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![BU of 8fzb by Molmil](/molmil-images/mine/8fzb) | Crystal structure of human FAM86A | Descriptor: | Protein-lysine N-methyltransferase EEF2KMT, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Shao, Z, Lu, J, Song, J. | Deposit date: | 2023-01-28 | Release date: | 2023-06-21 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | The FAM86 domain of FAM86A confers substrate specificity to promote EEF2-Lys525 methylation. J.Biol.Chem., 299, 2023
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5H3R
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![BU of 5h3r by Molmil](/molmil-images/mine/5h3r) | Crystal Structure of mutant MarR C80S from E.coli complexed with operator DNA | Descriptor: | DNA (5'-D(*CP*AP*TP*AP*CP*TP*TP*GP*CP*CP*TP*GP*GP*GP*CP*AP*AP*TP*AP*TP*T)-3'), DNA (5'-D(*GP*AP*AP*TP*AP*TP*TP*GP*CP*CP*CP*AP*GP*GP*CP*AP*AP*GP*TP*AP*T)-3'), Multiple antibiotic resistance protein MarR | Authors: | Zhu, R, Lou, H, Hao, Z. | Deposit date: | 2016-10-26 | Release date: | 2017-08-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Structural characterization of the DNA-binding mechanism underlying the copper(II)-sensing MarR transcriptional regulator. J. Biol. Inorg. Chem., 22, 2017
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3VOE
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![BU of 3voe by Molmil](/molmil-images/mine/3voe) | |
3VB2
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![BU of 3vb2 by Molmil](/molmil-images/mine/3vb2) | |
4NSP
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![BU of 4nsp by Molmil](/molmil-images/mine/4nsp) | Crystal structure of human ENDOV | Descriptor: | Endonuclease V | Authors: | Xie, W, Zhang, Z, Hao, Z. | Deposit date: | 2013-11-28 | Release date: | 2014-09-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of human endonuclease V as an inosine-specific ribonuclease. Acta Crystallogr.,Sect.D, 70, 2014
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4KR3
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![BU of 4kr3 by Molmil](/molmil-images/mine/4kr3) | Glycyl-tRNA synthetase mutant E71G in complex with tRNA-Gly | Descriptor: | GLYCINE, Gly-tRNA-CCC, Glycine--tRNA ligase, ... | Authors: | Qin, X, Hao, Z, Tian, Q, Zhang, Z, Zhou, C, Xie, W. | Deposit date: | 2013-05-16 | Release date: | 2014-05-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.235 Å) | Cite: | Cocrystal Structures of Glycyl-tRNA Synthetase in Complex with tRNA Suggest Multiple Conformational States in Glycylation J.Biol.Chem., 289, 2014
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4KR2
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![BU of 4kr2 by Molmil](/molmil-images/mine/4kr2) | Glycyl-tRNA synthetase in complex with tRNA-Gly | Descriptor: | ADENOSINE MONOPHOSPHATE, Gly-tRNA-CCC, Glycine--tRNA ligase | Authors: | Qin, X, Hao, Z, Tian, Q, Zhang, Z, Zhou, C, Xie, W. | Deposit date: | 2013-05-16 | Release date: | 2014-05-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.292 Å) | Cite: | Cocrystal Structures of Glycyl-tRNA Synthetase in Complex with tRNA Suggest Multiple Conformational States in Glycylation J.Biol.Chem., 289, 2014
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7YAC
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![BU of 7yac by Molmil](/molmil-images/mine/7yac) | Paltusotine-bound SSTR2-Gi complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhao, J, Shao, Z. | Deposit date: | 2022-06-27 | Release date: | 2023-04-19 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nat Commun, 14, 2023
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7YAE
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![BU of 7yae by Molmil](/molmil-images/mine/7yae) | Octreotide-bound SSTR2-Gi complex | Descriptor: | CHOLESTEROL, DPN-CYS-PHE-DTR-LYS-THR-CYS-THO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhao, J, Shao, Z. | Deposit date: | 2022-06-28 | Release date: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nat Commun, 14, 2023
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1GWZ
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![BU of 1gwz by Molmil](/molmil-images/mine/1gwz) | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1 | Descriptor: | SHP-1 | Authors: | Yang, J, Liang, X, Niu, T, Meng, W, Zhao, Z, Zhou, G.W. | Deposit date: | 1998-08-22 | Release date: | 1999-08-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1. J.Biol.Chem., 273, 1998
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6KG3
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![BU of 6kg3 by Molmil](/molmil-images/mine/6kg3) | |
6KH2
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![BU of 6kh2 by Molmil](/molmil-images/mine/6kh2) | |
6E59
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![BU of 6e59 by Molmil](/molmil-images/mine/6e59) | Crystal structure of the human NK1 tachykinin receptor | Descriptor: | 1-(4-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1H-1,2,3-triazol-5-yl)-N,N-dimethylmethanamine, Substance-P receptor, GlgA glycogen synthase, ... | Authors: | Yin, J, Clark, L, Chapman, K, Shao, Z, Borek, D, Xu, Q, Wang, J, Rosenbaum, D.M. | Deposit date: | 2018-07-19 | Release date: | 2018-12-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal structure of the human NK1tachykinin receptor. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7Y62
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![BU of 7y62 by Molmil](/molmil-images/mine/7y62) | Crystal structure of human TFEB HLHLZ domain | Descriptor: | Transcription factor EB | Authors: | Yang, G, Li, P, Lin, Y, Liu, Z, Sun, H, Zhao, Z, Fang, P, Wang, J. | Deposit date: | 2022-06-18 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB. Proc.Natl.Acad.Sci.USA, 120, 2023
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1TYZ
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![BU of 1tyz by Molmil](/molmil-images/mine/1tyz) | Crystal structure of 1-Aminocyclopropane-1-carboyxlate Deaminase from Pseudomonas | Descriptor: | 1-aminocyclopropane-1-carboxylate deaminase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | Authors: | Karthikeyan, S, Zhou, Q, Zhao, Z, Kao, C.L, Tao, Z, Robinson, H, Liu, H.W, Zhang, H. | Deposit date: | 2004-07-08 | Release date: | 2004-11-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Analysis of Pseudomonas 1-Aminocyclopropane-1-carboxylate Deaminase Complexes:Insight into the mechanism of unique pyrodoxial-5'-phosphate dependent cyclopropane ring opening reaction Biochemistry, 43, 2004
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1TZK
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![BU of 1tzk by Molmil](/molmil-images/mine/1tzk) | Crystal structure of 1-aminocyclopropane-1-carboxylate-deaminase complexed with alpha-keto-butyrate | Descriptor: | 1-aminocyclopropane-1-carboxylate deaminase, 2-KETOBUTYRIC ACID, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Karthikeyan, S, Zhou, Q, Zhao, Z, Kao, C.L, Tao, Z, Robinson, H, Liu, H.W, Zhang, H. | Deposit date: | 2004-07-10 | Release date: | 2004-11-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Analysis of Pseudomonas 1-Aminocyclopropane-1-carboxylate Deaminase Complexes: Insight into the Mechanism of a Unique Pyridoxal-5'-phosphate Dependent Cyclopropane Ring-Opening Reaction Biochemistry, 43, 2004
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1TZM
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![BU of 1tzm by Molmil](/molmil-images/mine/1tzm) | Crystal structure of ACC deaminase complexed with substrate analog b-chloro-D-alanine | Descriptor: | 1-aminocyclopropane-1-carboxylate deaminase, 3-chloro-D-alanine, AMINO-ACRYLATE, ... | Authors: | Karthikeyan, S, Zhou, Q, Zhao, Z, Kao, C.L, Tao, Z, Robinson, H, Liu, H.W, Zhang, H. | Deposit date: | 2004-07-10 | Release date: | 2004-11-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structural Analysis of Pseudomonas 1-Aminocyclopropane-1-carboxylate Deaminase Complexes: Insight into the Mechanism of a Unique Pyridoxal-5'-phosphate Dependent Cyclopropane Ring-Opening Reaction Biochemistry, 43, 2004
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1TZJ
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![BU of 1tzj by Molmil](/molmil-images/mine/1tzj) | Crystal Structure of 1-aminocyclopropane-1-carboxylate deaminase complexed with d-vinyl glycine | Descriptor: | 1-aminocyclopropane-1-carboxylate deaminase, D-VINYLGLYCINE, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Karthikeyan, S, Zhou, Q, Zhao, Z, Kao, C.L, Tao, Z, Robinson, H, Liu, H.W, Zhang, H. | Deposit date: | 2004-07-10 | Release date: | 2004-11-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural Analysis of Pseudomonas 1-Aminocyclopropane-1-carboxylate Deaminase Complexes: Insight into the Mechanism of a Unique Pyridoxal-5'-phosphate Dependent Cyclopropane Ring-Opening Reaction Biochemistry, 43, 2004
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1TZ2
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![BU of 1tz2 by Molmil](/molmil-images/mine/1tz2) | Crystal structure of 1-aminocyclopropane-1-carboyxlate deaminase complexed with ACC | Descriptor: | 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 1-aminocyclopropane-1-carboxylate deaminase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Karthikeyan, S, Zhou, Q, Zhao, Z, Kao, C.L, Tao, Z, Robinson, H, Liu, H.W, Zhang, H. | Deposit date: | 2004-07-09 | Release date: | 2004-11-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Analysis of Pseudomonas 1-Aminocyclopropane-1-carboxylate Deaminase Complexes: Insight into the Mechanism of a Unique Pyridoxal-5'-phosphate Dependent Cyclopropane Ring-Opening Reaction Biochemistry, 43, 2004
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1RQX
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![BU of 1rqx by Molmil](/molmil-images/mine/1rqx) | Crystal structure of ACC Deaminase complexed with Inhibitor | Descriptor: | 1-AMINOCYCLOPROPYLPHOSPHONATE, 1-aminocyclopropane-1-carboxylate deaminase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Karthikeyan, S, Zhao, Z, Kao, C.L, Zhou, Q, Tao, Z, Zhang, H, Liu, H.W. | Deposit date: | 2003-12-07 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural analysis of 1-aminocyclopropane-1-carboxylate deaminase: observation of an aminyl intermediate and identification of Tyr 294 as the active-site nucleophile. Angew.Chem.Int.Ed.Engl., 43, 2004
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7BR3
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![BU of 7br3 by Molmil](/molmil-images/mine/7br3) | Crystal structure of the protein 1 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R)-2,3-dihydroxypropyl dodecanoate, 4-[[(1R)-2-[5-(2-fluoranyl-3-methoxy-phenyl)-3-[[2-fluoranyl-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-bis(oxidanylidene)pyrimidin-1-yl]-1-phenyl-ethyl]amino]butanoic acid, ... | Authors: | Cheng, L, Shao, Z. | Deposit date: | 2020-03-26 | Release date: | 2020-10-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode. Nat Commun, 11, 2020
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4A82
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![BU of 4a82 by Molmil](/molmil-images/mine/4a82) | Fitted model of staphylococcus aureus sav1866 model ABC transporter in the human cystic fibrosis transmembrane conductance regulator volume map EMD-1966. | Descriptor: | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Authors: | Rosenberg, M.F, ORyan, L.P, Hughes, G, Zhao, Z, Aleksandrov, L.A, Riordan, J.R, Ford, R.C. | Deposit date: | 2011-11-18 | Release date: | 2012-01-11 | Last modified: | 2024-05-08 | Method: | ELECTRON CRYSTALLOGRAPHY (9 Å) | Cite: | The Cystic Fibrosis Transmembrane Conductance Regulator (Cftr):3D Structure and Localisation of a Channel Gate. J.Biol.Chem., 286, 2011
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