7DIY
 
 | | Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-exoribonuclease domain | | Descriptor: | MAGNESIUM ION, ZINC ION, nsp10 protein, ... | | Authors: | Lin, S, Chen, H, Chen, Z.M, Yang, F.L, Ye, F, Zheng, Y, Yang, J, Lin, X, Sun, H.L, Wang, L.L, Wen, A, Cao, Y, Lu, G.W. | | Deposit date: | 2020-11-19 | | Release date: | 2021-05-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.693 Å) | | Cite: | Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity.
Nucleic Acids Res., 49, 2021
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5Y28
 | | Crystal structure of H. pylori HtrA with PDZ2 deletion | | Descriptor: | 1,2-ETHANEDIOL, Periplasmic serine endoprotease DegP-like, UNK-UNK-UNK-UNK | | Authors: | Zhang, Z, Huang, Q, Tao, X. | | Deposit date: | 2017-07-24 | | Release date: | 2018-08-15 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3.08606815 Å) | | Cite: | The unique trimeric assembly of the virulence factor HtrA fromHelicobacter pylorioccurs via N-terminal domain swapping.
J.Biol.Chem., 294, 2019
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5Y2D
 | | Crystal structure of H. pylori HtrA | | Descriptor: | Periplasmic serine endoprotease DegP-like, UNK-UNK-K-UNK-UNK-UNK-UNK-UNK-UNK-UNK, UNK-UNK-UNK, ... | | Authors: | Zhang, Z, Huang, Q, Tao, X. | | Deposit date: | 2017-07-25 | | Release date: | 2018-08-15 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3.70009851 Å) | | Cite: | The unique trimeric assembly of the virulence factor HtrA fromHelicobacter pylorioccurs via N-terminal domain swapping.
J.Biol.Chem., 294, 2019
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8WUZ
 | | Development of 2-imino-2,3,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-4(1H)-one derivatives as human caseinolytic peptidase P (hClpP) activators | | Descriptor: | 5-[(3-fluorophenyl)methyl]-9-[[4-(trifluoromethyl)phenyl]methyl]-1,5,9,11-tetrazatricyclo[8.4.0.0^{2,7}]tetradeca-2(7),10-dien-8-one, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ... | | Authors: | Jiang, J.-X, Ding, H, Chen, M.-R, Lu, M.-L, Sun, H.-Y, Xiao, Y.-B. | | Deposit date: | 2023-10-22 | | Release date: | 2024-10-23 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Development of novel imipridone derivatives with potent anti-cancer activities as human caseinolytic peptidase P (hClpP) activators.
Bioorg.Chem., 153, 2024
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5H65
 | | Crystal structure of human POT1 and TPP1 | | Descriptor: | Adrenocortical dysplasia protein homolog, Protection of telomeres protein 1, ZINC ION | | Authors: | Chen, C, Wu, J, Lei, M. | | Deposit date: | 2016-11-10 | | Release date: | 2017-05-31 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.
Nat Commun, 8, 2017
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8XG1
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2023-12-14 | | Release date: | 2024-12-18 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.53 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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8XHF
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2023-12-17 | | Release date: | 2024-12-18 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.39 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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8XHH
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2023-12-17 | | Release date: | 2024-12-18 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.38 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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8XHG
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2023-12-17 | | Release date: | 2024-12-18 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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8XHE
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2023-12-17 | | Release date: | 2024-12-18 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.64 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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9GO1
 | | C1C2 Channelrhodopsin - SMX Dark structure | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Archaeal-type opsin 1,Archaeal-type opsin 2, RETINAL | | Authors: | Mulder, M, Weinert, T, Skopintsev, P, Bruenle, S, Broser, M, Hegemann, P, Standfuss, J. | | Deposit date: | 2024-09-04 | | Release date: | 2025-01-29 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Structural Insights Into the Opening Mechanism of C1C2 Channelrhodopsin.
J.Am.Chem.Soc., 147, 2025
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8XR9
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2024-01-06 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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8XRD
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2024-01-06 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.87 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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9GO2
 | | C1C2 Channelrhodopsin - SMX Light activated structure | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Archaeal-type opsin 1,Archaeal-type opsin 2, RETINAL | | Authors: | Mulder, M, Weinert, T, Skopintsev, P, Bruenle, S, Broser, M, Hegemann, P, Standfuss, J. | | Deposit date: | 2024-09-04 | | Release date: | 2025-01-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural Insights Into the Opening Mechanism of C1C2 Channelrhodopsin.
J.Am.Chem.Soc., 147, 2025
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8XRA
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid, ... | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2024-01-06 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.31 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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8XR8
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2024-01-06 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.53 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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8XRB
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2024-01-06 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.49 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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8XRC
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2024-01-06 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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8XR7
 | | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | | Authors: | Sun, J, Zheng, T.Y. | | Deposit date: | 2024-01-06 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.62 Å) | | Cite: | Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Nat Commun, 15, 2024
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7YUY
 | | Structure of a mutated membrane-bound glycosyltransferase | | Descriptor: | (11R,14S)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate, 1,3-beta-glucan synthase component FKS1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Hu, X.L, Yang, P, Zhang, M, Liu, X.T, Yu, H.J. | | Deposit date: | 2022-08-18 | | Release date: | 2023-03-29 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural and mechanistic insights into fungal beta-1,3-glucan synthase FKS1.
Nature, 616, 2023
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5TCA
 | | Complement Factor D inhibited with JH3 | | Descriptor: | 1-(2-{(2S)-2-[(6-bromopyridin-2-yl)carbamoyl]-1,3-thiazolidin-3-yl}-2-oxoethyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide, Complement factor D | | Authors: | Stuckey, J.A. | | Deposit date: | 2016-09-14 | | Release date: | 2016-10-19 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.
ACS Med Chem Lett, 7, 2016
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5TKB
 | | CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND | | Descriptor: | ETHANOL, MAGNESIUM ION, N-[(2R)-2,3-dihydroxy-2-methylpropyl]-8-(methylamino)-6-[(2,3,5,6-tetrafluorophenyl)amino]imidazo[1,2-b]pyridazine-3-carboxamide, ... | | Authors: | Sack, J.S. | | Deposit date: | 2016-10-06 | | Release date: | 2016-12-28 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.
Medchemcomm, 8, 2017
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5TKD
 | | CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE | | Descriptor: | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2, SULFATE ION | | Authors: | Muckelbauer, J.K. | | Deposit date: | 2016-10-06 | | Release date: | 2016-12-28 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.
Medchemcomm, 8, 2017
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7W1S
 | | Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-007 | | Descriptor: | Nanobody Nb-007, Spike protein S1 | | Authors: | Yang, J, Lin, S, Sun, H.L, Lu, G.W. | | Deposit date: | 2021-11-20 | | Release date: | 2022-06-29 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.997 Å) | | Cite: | A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding.
Front Immunol, 13, 2022
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5TCC
 | | Complement Factor D inhibited with JH4 | | Descriptor: | (2S)-N-(6-bromopyridin-2-yl)-3-[(1H-indazol-1-yl)acetyl]-1,3-thiazolidine-2-carboxamide, Complement factor D | | Authors: | Stuckey, J.A. | | Deposit date: | 2016-09-14 | | Release date: | 2016-10-19 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.37 Å) | | Cite: | Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.
ACS Med Chem Lett, 7, 2016
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