5J7L
 
 | | Structure of the 70S E coli ribosome with the U1052G mutation in the 16S rRNA bound to tetracycline | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | | Authors: | Cocozaki, A, Ferguson, A. | | Deposit date: | 2016-04-06 | | Release date: | 2016-07-27 | | Last modified: | 2018-08-15 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5JG8
 | | Crystal structure of human acid sphingomyelinase | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Xiong, Z.J, Prive, G.G. | | Deposit date: | 2016-04-19 | | Release date: | 2016-07-06 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis.
J.Mol.Biol., 428, 2016
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5J91
 | | Structure of the Wild-type 70S E coli ribosome bound to Tigecycline | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | | Authors: | Cocozaki, A, Ferguson, A. | | Deposit date: | 2016-04-08 | | Release date: | 2016-07-06 | | Last modified: | 2016-08-03 | | Method: | X-RAY DIFFRACTION (2.96 Å) | | Cite: | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5J5B
 | | Structure of the WT E coli ribosome bound to tetracycline | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | | Authors: | Cocozaki, A, Ferguson, A. | | Deposit date: | 2016-04-01 | | Release date: | 2016-07-27 | | Last modified: | 2018-08-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.
Proc.Natl.Acad.Sci.USA, 113, 2016
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3N2R
 | | Structure of neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R/3S,4S)-4-(3-Phenoxyphenoxy)pyrrolidin-3-yl)methyl)pyridin-2-amine | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-{[(3R,4R)-4-(3-phenoxyphenoxy)pyrrolidin-3-yl]methyl}pyridin-2-amine, ACETATE ION, ... | | Authors: | Li, H, Poulos, T.L. | | Deposit date: | 2010-05-18 | | Release date: | 2010-08-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.
Bioorg.Med.Chem., 18, 2010
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5IL0
 | | Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation | | Descriptor: | 1,2-ETHANEDIOL, BROMIDE ION, METTL14, ... | | Authors: | Wang, X, Guan, Z, Zou, T, Yin, P. | | Deposit date: | 2016-03-04 | | Release date: | 2016-05-25 | | Last modified: | 2016-06-29 | | Method: | X-RAY DIFFRACTION (1.882 Å) | | Cite: | Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
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5IL1
 | | Crystal structure of SAM-bound METTL3-METTL14 complex | | Descriptor: | 1,2-ETHANEDIOL, METTL14, METTL3, ... | | Authors: | Wang, X, Guan, Z, Zou, T, Yin, P. | | Deposit date: | 2016-03-04 | | Release date: | 2016-05-25 | | Last modified: | 2016-06-29 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
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5IL2
 | | Crystal structure of SAH-bound METTL3-METTL14 complex | | Descriptor: | 1,2-ETHANEDIOL, METTL14, METTL3, ... | | Authors: | Wang, X, Guan, Z, Zou, T, Yin, P. | | Deposit date: | 2016-03-04 | | Release date: | 2016-05-25 | | Last modified: | 2016-06-29 | | Method: | X-RAY DIFFRACTION (1.606 Å) | | Cite: | Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
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7CMA
 | | Structure of A151R from African swine fever virus Georgia | | Descriptor: | A151R, ZINC ION | | Authors: | Niu, D, Liu, K, Huang, J, Chen, C, Liu, W, Guo, R. | | Deposit date: | 2020-07-26 | | Release date: | 2021-06-02 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Structure basis of non-structural protein pA151R from African Swine Fever Virus.
Biochem.Biophys.Res.Commun., 532, 2020
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6BTE
 | | DNA Polymerase Beta I260Q Binary Complex | | Descriptor: | CHLORIDE ION, DNA Downstream Strand, DNA Primer Strand, ... | | Authors: | Eckenroth, B.E, Doublie, S. | | Deposit date: | 2017-12-06 | | Release date: | 2018-09-26 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | I260Q DNA polymerase beta highlights precatalytic conformational rearrangements critical for fidelity.
Nucleic Acids Res., 46, 2018
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8IJS
 | | anti-VEGF nanobody mutant | | Descriptor: | ZINC ION, anti-VEGF nanobody | | Authors: | Qian, F, Zhu, S.Q. | | Deposit date: | 2023-02-28 | | Release date: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.752 Å) | | Cite: | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
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8IIU
 | | anti-VEGF nanobody | | Descriptor: | SULFATE ION, anti-VEGF nanobody | | Authors: | Qian, F, Zhu, S.Q. | | Deposit date: | 2023-02-24 | | Release date: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.27 Å) | | Cite: | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
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8IJZ
 | | anti-VEGF mutant | | Descriptor: | anti-VEGF nanobody | | Authors: | Qian, F, Zhu, S.Q. | | Deposit date: | 2023-02-28 | | Release date: | 2023-12-27 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | | Cite: | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
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6BTF
 | | DNA Polymerase Beta I260Q Ternary Complex | | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DNA Downstream Strand, DNA Primer Strand, ... | | Authors: | Eckenroth, B.E, Doublie, S. | | Deposit date: | 2017-12-06 | | Release date: | 2018-09-26 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | I260Q DNA polymerase beta highlights precatalytic conformational rearrangements critical for fidelity.
Nucleic Acids Res., 46, 2018
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4Q6I
 | | Crystal structure of murine 2D5 Fab, a potent anti-CD4 HIV-1-neutralizing antibody in complex with CD4 | | Descriptor: | Heavy chain of murine 2D5 Fab, Light chain of murine 2D5 Fab, T-cell surface glycoprotein CD4 | | Authors: | Boyington, J.C, Nabel, G.J, Mascola, J.R. | | Deposit date: | 2014-04-22 | | Release date: | 2014-07-23 | | Method: | X-RAY DIFFRACTION (3.65 Å) | | Cite: | Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor.
Sci Transl Med, 6, 2014
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4RQU
 | | Alcohol Dehydrogenase crystal structure in complex with NAD | | Descriptor: | Alcohol Dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION | | Authors: | Xu, Y.W. | | Deposit date: | 2014-11-05 | | Release date: | 2014-12-17 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural insight into the conformational change of alcohol dehydrogenase from arabidopsis Thalianal during coenzyme binding.
Biochimie, 108C, 2014
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6KZE
 | | The crystal structue of PDE10A complexed with 4d | | Descriptor: | 8-[(E)-2-[5-methyl-1-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]benzimidazol-2-yl]ethenyl]quinoline, MAGNESIUM ION, ZINC ION, ... | | Authors: | Yang, Y, Zhang, S, Zhou, Q, Huang, Y.-Y, Guo, L, Luo, H.-B. | | Deposit date: | 2019-09-24 | | Release date: | 2020-09-30 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.50003481 Å) | | Cite: | Novel Potent and Highly Selective Benzoimidazole-based Phosphodiesterase 10 Inhibitors with Improved Solubility and Pharmacokinetic Properties for the Treatment of Pulmonary Arterial Hypertension
To Be Published
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4OWW
 | | Structural basis of SOSS1 in complex with a 35nt ssDNA | | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), Integrator complex subunit 3, SOSS complex subunit B1, ... | | Authors: | Ren, W, Sun, Q, Tang, X, Song, H. | | Deposit date: | 2014-02-04 | | Release date: | 2014-04-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA.
Cell Rep, 6, 2014
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4RQT
 | | Alcohol Dehydrogenase Crystal Structure | | Descriptor: | ACETIC ACID, Alcohol dehydrogenase class-P, SULFATE ION, ... | | Authors: | Xu, Y.W. | | Deposit date: | 2014-11-05 | | Release date: | 2014-12-17 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insight into the conformational change of alcohol dehydrogenase from arabidopsis Thalianal during coenzyme binding.
Biochimie, 108C, 2014
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4OWT
 | | Structural basis of SOSS1 complex assembly | | Descriptor: | Integrator complex subunit 3, SOSS complex subunit B1, SOSS complex subunit C | | Authors: | Ren, W, Sun, Q, Tang, X, Song, H. | | Deposit date: | 2014-02-03 | | Release date: | 2014-04-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA.
Cell Rep, 6, 2014
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4OWX
 | | Structural basis of SOSS1 in complex with a 12nt ssDNA | | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Integrator complex subunit 3, SOSS complex subunit B1 | | Authors: | Ren, W, Sun, Q, Tang, X, Song, H. | | Deposit date: | 2014-02-04 | | Release date: | 2014-04-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA.
Cell Rep, 6, 2014
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7T8N
 | | Crystal structure of the PNAG binding module PgaA-TPR 220-359 | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Poly-beta-1,6-N-acetyl-D-glucosamine export protein | | Authors: | Pfoh, R, Little, D.J, Howell, P.L. | | Deposit date: | 2021-12-16 | | Release date: | 2022-08-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing.
Plos Pathog., 18, 2022
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8HL9
 | | Crystal structure of Galectin-8 C-CRD with part of linker | | Descriptor: | Galectin-8 | | Authors: | Si, Y.L. | | Deposit date: | 2022-11-29 | | Release date: | 2023-07-05 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Linker remodels human Galectin-8 structure and regulates its hemagglutination and pro-apoptotic activity.
Int.J.Biol.Macromol., 245, 2023
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6UCH
 | | SMARCB1 nucleosome-interacting C-terminal alpha helix | | Descriptor: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | | Authors: | Valencia, A.M, Sun, Z.Y.J, Seo, H.S, Vangos, H.S, Yeoh, Z.C, Mashtalir, N, Dhe-Paganon, S, Kadoch, C. | | Deposit date: | 2019-09-16 | | Release date: | 2019-11-27 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling.
Cell, 179, 2019
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8K6C
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