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LOW TEMPERATURE STRUCTURE OF WILD-TYPE IDH COMPLEXED WITH MG-ISOCITRATE
Descriptor:	ISOCITRATE DEHYDROGENASE, ISOCITRIC ACID, MAGNESIUM ION, ...
Authors:	Stroud, M.R, Finer-Moore, J.
Deposit date:	1999-08-25
Release date:	1999-09-01
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase. J.Mol.Biol., 295, 2000

3KL4

Recognition of a signal peptide by the signal recognition particle
Descriptor:	Signal peptide of yeast dipeptidyl aminopeptidase B, Signal recognition 54 kDa protein
Authors:	Janda, C.Y, Nagai, K, Li, J, Oubridge, C.
Deposit date:	2009-11-06
Release date:	2010-03-31
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (3.5 Å)
Cite:	Recognition of a signal peptide by the signal recognition particle. Nature, 465, 2010

3INK

UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY
Descriptor:	INTERLEUKIN-2
Authors:	Mckay, D.B, Brandhuber, B.J.
Deposit date:	1992-12-09
Release date:	1993-10-31
Last modified:	2024-06-05
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Response. Science, 257, 1992

4O1X

Crystal structure of human thymidylate synthase double mutant C195S-Y202C
Descriptor:	1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
Authors:	Pozzi, C, Mangani, S.
Deposit date:	2013-12-16
Release date:	2015-01-21
Last modified:	2023-03-01
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. Elife, 11, 2022

1ABT

NMR SOLUTION STRUCTURE OF AN ALPHA-BUNGAROTOXIN(SLASH)NICOTINIC RECEPTOR PEPTIDE COMPLEX
Descriptor:	ALPHA-BUNGAROTOXIN, NICOTINIC RECEPTOR PEPTIDE
Authors:	Basus, V.J, Song, G, Hawrot, E.
Deposit date:	1993-11-17
Release date:	1994-01-31
Last modified:	2022-02-16
Method:	SOLUTION NMR
Cite:	NMR solution structure of an alpha-bungarotoxin/nicotinic receptor peptide complex. Biochemistry, 32, 1993

1BIT

THE CRYSTAL STRUCTURE OF ANIONIC SALMON TRYPSIN IN A SECOND CRYSTAL FORM
Descriptor:	BENZAMIDINE, CALCIUM ION, SULFATE ION, ...
Authors:	Berglund, G.I.
Deposit date:	1994-08-26
Release date:	1994-11-01
Last modified:	2019-08-14
Method:	X-RAY DIFFRACTION (1.83 Å)
Cite:	Structure of anionic salmon trypsin in a second crystal form. Acta Crystallogr.,Sect.D, 51, 1995

4O1U

Crystal structure of human thymidylate synthase mutant Y202C
Descriptor:	1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
Authors:	Pozzi, C, Mangani, S.
Deposit date:	2013-12-16
Release date:	2015-01-21
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.26 Å)
Cite:	Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. Elife, 11, 2022

1TYS

WATER-MEDIATED SUBSTRATE(SLASH)PRODUCT DISCRIMINATION: THE PRODUCT COMPLEX OF THYMIDYLATE SYNTHASE AT 1.83 ANGSTROMS
Descriptor:	DIHYDROFOLIC ACID, THYMIDINE-5'-PHOSPHATE, THYMIDYLATE SYNTHASE
Authors:	Fauman, E, Rutenber, E, Stroud, R.
Deposit date:	1993-05-07
Release date:	1994-06-22
Last modified:	2024-06-05
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A. Biochemistry, 33, 1994

5V5Z

Structure of CYP51 from the pathogen Candida albicans
Descriptor:	2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:	Keniya, M.V, Sabherwal, M, Wilson, R.K, Sagatova, A.A, Tyndall, J.D.A, Monk, B.C.
Deposit date:	2017-03-15
Release date:	2017-03-29
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Crystal Structures of Full-Length Lanosterol 14 alpha-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery. Antimicrob.Agents Chemother., 62, 2018

4KPW

Crystal structure of His-tagged human thymidylate synthase R175A mutant
Descriptor:	1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase
Authors:	Pozzi, C, Mangani, S.
Deposit date:	2013-05-14
Release date:	2014-05-14
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.03 Å)
Cite:	Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem., 58, 2015

1GBT

STRUCTURE OF AN ACYL-ENZYME INTERMEDIATE DURING CATALYSIS: (GUANIDINOBENZOYL) TRYPSIN
Descriptor:	4-carbamimidamidobenzoic acid, BETA-TRYPSIN, CALCIUM ION, ...
Authors:	Singer, P.T, Sweet, R.M.
Deposit date:	1991-09-17
Release date:	1994-01-31
Last modified:	2024-06-19
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structure of an acyl-enzyme intermediate during catalysis: (guanidinobenzoyl)trypsin. Biochemistry, 29, 1990

2PQU

Crystal structure of KH1 domain of human PCBP2 complexed to single-stranded 12-mer telomeric dna
Descriptor:	12-mer C-rich strand of human telomeric DNA, Poly(rC)-binding protein 2
Authors:	James, T.L, Lee, J.
Deposit date:	2007-05-02
Release date:	2007-06-12
Last modified:	2019-07-24
Method:	X-RAY DIFFRACTION (2.12 Å)
Cite:	X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. Rna, 13, 2007

2PY9

Protein-RNA Interaction involving KH1 domain from Human Poly(C)-Binding Protein-2
Descriptor:	12-mer C-rich strand of human telomeric RNA, Poly(rC)-binding protein 2
Authors:	James, T.L, Du, Z, Lee, J.K.
Deposit date:	2007-05-15
Release date:	2007-06-12
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.56 Å)
Cite:	X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. Rna, 13, 2007

1LS1

T. aquaticus Ffh NG Domain at 1.1A Resolution
Descriptor:	MAGNESIUM ION, OXYGEN MOLECULE, SIGNAL RECOGNITION PARTICLE PROTEIN
Authors:	Ramirez, U.D, Minasov, G, Freymann, D.M.
Deposit date:	2002-05-16
Release date:	2002-11-16
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.1 Å)
Cite:	Structural Basis for Mobility in the 1.1 A Crystal Structure of the NG Domain of Thermus aquaticus Ffh J.Mol.Biol., 320, 2002

1TRM

THE THREE-DIMENSIONAL STRUCTURE OF ASN102 MUTANT OF TRYPSIN. ROLE OF ASP102 IN SERINE PROTEASE CATALYSIS
Descriptor:	BENZAMIDINE, CALCIUM ION, TRYPSIN
Authors:	Sprang, S, Standing, T, Fletterick, R.J.
Deposit date:	1987-10-21
Release date:	1988-07-16
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science, 237, 1987

4ZDZ

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with fluconazole
Descriptor:	2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:	Sagatova, A, Keniya, M.V, Wilson, R.K, Tyndall, J.D.A, Monk, B.C.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

4ZE0

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with Voriconazole
Descriptor:	Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole
Authors:	Sagatova, A, Keniya, M.V, Wilson, R, Tyndall, J.D.A, Monk, B.C.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

4ZDY

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with itraconazole
Descriptor:	2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:	Sagatova, A, Keniya, M.V, Wilson, R.K, Tyndall, J.D.A, Monk, B.C.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.02 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

4ZE3

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with fluconazole
Descriptor:	2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:	Sagatova, A, Keniya, M.V, Wilson, R, Monk, B.C, Tyndall, J.D.A.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

4ZE1

Saccharomyces cerevisiae CYP51 Y140F mutant complexed with posaconazole in the active site
Descriptor:	Lanosterol 14-alpha demethylase, POSACONAZOLE, PROTOPORPHYRIN IX CONTAINING FE
Authors:	Sagatova, A, Keniya, M.V, Wilson, R, Tyndall, J.D.A, Monk, B.C.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

4ZE2

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with itraconazole
Descriptor:	2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:	Sagatova, A, Keniya, M.V, Wilson, R, Monk, B.C, Tyndall, J.D.A.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

1C1P

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.37 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C2M

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	CALCIUM ION, MAGNESIUM ION, SULFATE ION, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C2G

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANE KETONE HYDRATE, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C1N

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	BENZAMIDINE, CALCIUM ION, SULFATE ION, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

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