4O1X
Crystal structure of human thymidylate synthase double mutant C195S-Y202C
Summary for 4O1X
Entry DOI | 10.2210/pdb4o1x/pdb |
Related | 4O1U |
Descriptor | Thymidylate synthase, SULFATE ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | dimer-dimer interface modification, active conformation, methyltransferase, nucleotide biosynthesis, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P04818 P04818 |
Total number of polymer chains | 4 |
Total formula weight | 150394.03 |
Authors | Pozzi, C.,Mangani, S. (deposition date: 2013-12-16, release date: 2015-01-21, Last modification date: 2023-03-01) |
Primary citation | Costantino, L.,Ferrari, S.,Santucci, M.,Salo-Ahen, O.M.H.,Carosati, E.,Franchini, S.,Lauriola, A.,Pozzi, C.,Trande, M.,Gozzi, G.,Saxena, P.,Cannazza, G.,Losi, L.,Cardinale, D.,Venturelli, A.,Quotadamo, A.,Linciano, P.,Tagliazucchi, L.,Moschella, M.G.,Guerrini, R.,Pacifico, S.,Luciani, R.,Genovese, F.,Henrich, S.,Alboni, S.,Santarem, N.,da Silva Cordeiro, A.,Giovannetti, E.,Peters, G.J.,Pinton, P.,Rimessi, A.,Cruciani, G.,Stroud, R.M.,Wade, R.C.,Mangani, S.,Marverti, G.,D'Arca, D.,Ponterini, G.,Costi, M.P. Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. Elife, 11:-, 2022 Cited by PubMed: 36475542DOI: 10.7554/eLife.73862 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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