5V5Z

Structure of CYP51 from the pathogen Candida albicans

Summary for 5V5Z

• Entry DOI: 10.2210/pdb5v5z/pdb
• Related: 5EQB 5JLC
• Descriptor: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one (3 entities in total)
• Functional Keywords: pathogen, candida albicans, cyp51, itraconazole, oxidoreductase-oxidoreducatse inhibitor complex, oxidoreductase/oxidoreducatse inhibitor
• Biological source: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
• Total number of polymer chains: 1
• Total formula weight: 63170.55

Authors

Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Sagatova, A.A.,Tyndall, J.D.A.,Monk, B.C. (deposition date: 2017-03-15, release date: 2017-03-29, Last modification date: 2023-10-04)

• Primary citation: Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Woods, M.A.,Sagatova, A.A.,Tyndall, J.D.A.,Monk, B.C.; Crystal Structures of Full-Length Lanosterol 14 alpha-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.; Antimicrob.Agents Chemother., 62:-, 2018; PubMed: 30126961; DOI: 10.1128/AAC.01134-18

Experimental method

X-RAY DIFFRACTION (2.9 Å)