5JLC
Structure of CYP51 from the pathogen Candida glabrata
Summary for 5JLC
Entry DOI | 10.2210/pdb5jlc/pdb |
Descriptor | Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, ... (7 entities in total) |
Functional Keywords | pathogen, candida glabrata, cyp51, itraconazole, oxidoreductase-oxidoreducatse inhibitor complex, oxidoreductase/oxidoreducatse inhibitor |
Biological source | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) |
Total number of polymer chains | 1 |
Total formula weight | 61109.33 |
Authors | Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Sagatova, A.A.,Tyndall, J.D.A.,Monk, B.C. (deposition date: 2016-04-26, release date: 2016-05-25, Last modification date: 2023-09-27) |
Primary citation | Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Woods, M.A.,Sagatova, A.A.,Tyndall, J.D.A.,Monk, B.C. Crystal Structures of Full-Length Lanosterol 14 alpha-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery. Antimicrob.Agents Chemother., 62:-, 2018 Cited by PubMed: 30126961DOI: 10.1128/AAC.01134-18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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