4ZE3

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with fluconazole

Summary for 4ZE3

Entry DOI	10.2210/pdb4ze3/pdb
Related	4K0F 4LXJ 4WMZ 4ZDY 4ZDZ 4ZE0 4ZE1 4ZE2
Descriptor	Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total)
Functional Keywords	fluconazole, cyp51, oxidoreductase-oxidoreductase inhibitor complex, y140h, resistance mutation, oxidoreductase-oxidoreducatse inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Total number of polymer chains	1
Total formula weight	62782.94
Authors	Sagatova, A.,Keniya, M.V.,Wilson, R.,Monk, B.C.,Tyndall, J.D.A. (deposition date: 2015-04-20, release date: 2016-03-30, Last modification date: 2023-09-27)
Primary citation	Sagatova, A.A.,Keniya, M.V.,Wilson, R.K.,Sabherwal, M.,Tyndall, J.D.,Monk, B.C. Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6:26213-26213, 2016 Cited by PubMed: 27188873 DOI: 10.1038/srep26213 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation