4ZE2

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with itraconazole

Summary for 4ZE2

Entry DOI	10.2210/pdb4ze2/pdb
Related	4K0F 4LXJ 4WMZ
Descriptor	Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, ... (4 entities in total)
Functional Keywords	cyp51, oxidoreductase-oxidoreductase inhibitor complex, resistance mutation, oxidoreductase/oxidoreductase inhibitor
Biological source	Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Total number of polymer chains	1
Total formula weight	63182.30
Authors	Sagatova, A.,Keniya, M.V.,Wilson, R.,Monk, B.C.,Tyndall, J.D.A. (deposition date: 2015-04-20, release date: 2016-03-30, Last modification date: 2023-09-27)
Primary citation	Sagatova, A.A.,Keniya, M.V.,Wilson, R.K.,Sabherwal, M.,Tyndall, J.D.,Monk, B.C. Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6:26213-26213, 2016 Cited by PubMed: 27188873 DOI: 10.1038/srep26213 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation