4ZE2
Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with itraconazole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lanosterol 14-alpha demethylase | polymer | 539 | 61860.2 | 1 | UniProt (A6ZSR0) | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) | |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one | non-polymer | 705.6 | 1 | Chemie (1YN) PubChem (3793) PubChem (21309254) PubChem (55283) PubChem (25103690) PubChem (25261097) PubChem (24867300) PubChem (56682298) PubChem (58612883) PubChem (56675666) PubChem (14179008) PubChem (14179012) PubChem (6917738) PubChem (9961741) PubChem (91563952) PubChem (14179009) PubChem (14179010) PubChem (14179011) PubChem (14179013) PubChem (122699344) PubChem (122699348) PubChem (153052543) PubChem (161302809) | |||
| 4 | D (A) | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A: 1 - 530 (UniProt: A6ZSR0)
| PDB | External Database | Details |
|---|---|---|
| His 140 | Tyr 140 | engineered mutation |
| Gly 531 | - | expression tag |
| Gly 532 | - | expression tag |
| Arg 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
| His 536 | - | expression tag |
| His 537 | - | expression tag |
| His 538 | - | expression tag |
| His 539 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 61860.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1322.1 | |
| All* | Total formula weight | 63182.3 |
