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4ZE2

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with itraconazole

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0006696biological_processergosterol biosynthetic process
A0008398molecular_functionsterol 14-demethylase activity
A0016020cellular_componentmembrane
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0020037molecular_functionheme binding
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue HEM A 601
ChainResidue
APHE113
AARG385
APRO462
APHE463
AGLY464
AHIS468
ACYS470
AILE471
AGLY472
A1YN602
AHOH835
ATYR126
AHIS140
ALEU147
ALYS151
AGLY315
ATHR318
APRO379
ALEU383

site_idAC2
Number of Residues19
Detailsbinding site for residue 1YN A 602
ChainResidue
AALA69
ATYR72
AGLY73
ATYR126
ALEU129
APHE134
AILE139
AHIS140
APHE236
APRO238
AGLY310
AGLY314
ASER382
APHE384
ATHR507
ASER508
AMET509
AHEM601
AHOH879

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgGRHRCIG
ChainResidueDetails
APHE463-GLY472

251422

PDB entries from 2026-04-01

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