1J04
 
 | | Structural mechanism of enzyme mistargeting in hereditary kidney stone disease in vitro | | Descriptor: | (AMINOOXY)ACETIC ACID, GLYCEROL, alanine--glyoxylate aminotransferase | | Authors: | Zhang, X, Djordjevic, S, Bartlam, M, Ye, S, Rao, Z, Danpure, C.J. | | Deposit date: | 2002-10-30 | | Release date: | 2003-11-11 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting.
Acta Crystallogr.,Sect.F, 66, 2010
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5NWT
 | | Crystal Structure of Escherichia coli RNA polymerase - Sigma54 Holoenzyme complex | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Zhang, X, Buck, M, Darbari, V.C, Yang, Y, Zhang, N, Lu, D, Glyde, R, Wang, Y, Winkelman, J, Gourse, R.L, Murakami, K.S. | | Deposit date: | 2017-05-08 | | Release date: | 2017-09-13 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.76 Å) | | Cite: | TRANSCRIPTION. Structures of the RNA polymerase-Sigma54 reveal new and conserved regulatory strategies.
Science, 349, 2015
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5Y14
 | | Crystal structure of LP-40/N44 | | Descriptor: | LP-40, N44 | | Authors: | Zhang, X, Wang, X, He, Y. | | Deposit date: | 2017-07-19 | | Release date: | 2017-11-08 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.762 Å) | | Cite: | Enfuvirtide (T20)-Based Lipopeptide Is a Potent HIV-1 Cell Fusion Inhibitor: Implications for Viral Entry and Inhibition
J. Virol., 91, 2017
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7OZR
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6LCY
 | | Crystal structure of Synaptotagmin-7 C2B in complex with IP6 | | Descriptor: | INOSITOL HEXAKISPHOSPHATE, Synaptotagmin-7 | | Authors: | Zhang, Y, Zhang, X, Rao, F, Wang, C. | | Deposit date: | 2019-11-20 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | 5-IP 7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis.
Nat Metab, 3, 2021
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5XWY
 | | Electron cryo-microscopy structure of LbuCas13a-crRNA binary complex | | Descriptor: | A type VI-A CRISPR-Cas RNA-guided RNA ribonuclease, Cas13a, RNA (59-MER) | | Authors: | Zhang, X, Wang, Y, Ma, J, Liu, L, Li, X, Li, Z, You, L, Wang, J, Wang, M. | | Deposit date: | 2017-06-30 | | Release date: | 2017-09-13 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a.
Cell, 170, 2017
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5XUR
 | | Crystal Structure of Rv2466c C22S Mutant | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Thioredoxin-like reductase Rv2466c | | Authors: | Zhang, X, Li, H. | | Deposit date: | 2017-06-25 | | Release date: | 2018-03-14 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.996 Å) | | Cite: | Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.
ACS Infect Dis, 4, 2018
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6X19
 | | Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor | | Descriptor: | 3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Belousoff, M.J, Zhang, X, Danev, R. | | Deposit date: | 2020-05-18 | | Release date: | 2020-09-09 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (2.1 Å) | | Cite: | Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
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6X18
 | | GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor | | Descriptor: | Glucagon, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Belousoff, M.J, Zhang, X, Danev, R. | | Deposit date: | 2020-05-18 | | Release date: | 2020-09-09 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (2.1 Å) | | Cite: | Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
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6X1A
 | | Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor | | Descriptor: | 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Belousoff, M.J, Zhang, X, Danev, R. | | Deposit date: | 2020-05-18 | | Release date: | 2020-09-09 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
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5FB1
 | | Crystal Structure of a PHD finger bound to histone H3 K9me3 peptide | | Descriptor: | MALONATE ION, Nuclear autoantigen Sp-100, Peptide from Histone H3, ... | | Authors: | Li, H, Zhang, X. | | Deposit date: | 2015-12-13 | | Release date: | 2016-05-04 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C
J.Biol.Chem., 291, 2016
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5FB0
 | | Crystal Structure of a PHD finger bound to histone H3 T3ph peptide | | Descriptor: | Nuclear autoantigen Sp-100, Peptide from Histone H3, ZINC ION | | Authors: | Li, H, Zhang, X. | | Deposit date: | 2015-12-13 | | Release date: | 2016-05-04 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.702 Å) | | Cite: | Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C
J.Biol.Chem., 291, 2016
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2Z41
 | | Crystal Structure Analysis of the Ski2-type RNA helicase | | Descriptor: | MAGNESIUM ION, putative ski2-type helicase | | Authors: | Nakashima, T, Zhang, X, Kakuta, Y, Yao, M, Tanaka, I, Kimura, M. | | Deposit date: | 2007-06-12 | | Release date: | 2008-04-08 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.51 Å) | | Cite: | Crystal structure of an archaeal Ski2p-like protein from Pyrococcus horikoshii OT3
Protein Sci., 17, 2008
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5TEB
 | | Crystal Structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RPP1 | | Descriptor: | Recognition of Peronospora parasitica 1 | | Authors: | Bentham, A.R, Zhang, X, Croll, T, Williams, S, Kobe, B. | | Deposit date: | 2016-09-20 | | Release date: | 2017-02-01 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.796 Å) | | Cite: | Multiple functional self-association interfaces in plant TIR domains.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1RHP
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5GQH
 | | Cryo-EM structure of PaeCas3-AcrF3 complex | | Descriptor: | CRISPR-associated nuclease/helicase Cas3 subtype I-F/YPEST, anti-CRISPR protein 3 | | Authors: | Zhang, X, Ma, J, Wang, Y, Wang, J. | | Deposit date: | 2016-08-07 | | Release date: | 2016-09-21 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses
Cell Res., 26, 2016
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3O5X
 | | Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor | | Descriptor: | 3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11 | | Authors: | Zhang, Z.-Y, Zhang, X, He, Y, Liu, S, Yu, Z, Jiang, Z, Yang, Z, Dong, Y, Nabinger, S.C, Wu, L, Gunawan, A.M, Wang, L, Chan, R.J. | | Deposit date: | 2010-07-28 | | Release date: | 2010-08-11 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
J.Med.Chem., 53, 2010
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4O9L
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4O9F
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4OA7
 | | Crystal structure of Tankyrase1 in complex with IWR1 | | Descriptor: | 4-[(3aR,4R,7S,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide, Tankyrase-1, ZINC ION | | Authors: | Zhang, X, He, H. | | Deposit date: | 2014-01-03 | | Release date: | 2015-01-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.
Mol.Cell.Biol., 35, 2015
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2QVJ
 | | Crystal structure of a vesicular stomatitis virus nucleocapsid protein Ser290Trp mutant | | Descriptor: | Nucleocapsid protein | | Authors: | Luo, M, Green, T.J, Zhang, X, Tsao, J, Qiu, S. | | Deposit date: | 2007-08-08 | | Release date: | 2008-01-08 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Role of intermolecular interactions of vesicular stomatitis virus nucleoprotein in RNA encapsidation.
J.Virol., 82, 2008
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7YSK
 | | Crystal structure of D-Cysteine desulfhydrase from Pectobacterium atrosepticum | | Descriptor: | D-Cysteine desulfhydrase | | Authors: | Zhang, X, Wang, L, Xu, X, Xing, X, Zhou, J. | | Deposit date: | 2022-08-12 | | Release date: | 2022-12-14 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Characterization and structural basis of D-cysteine desulfhydrase from Pectobacterium atrosepticum
Tetrahedron, 2022
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7YSL
 | | Crystal structure of D-Cysteine desulfhydrase with a trapped PLP-pyruvate geminal diamine | | Descriptor: | 1,2-ETHANEDIOL, D-Cysteine desulfhydrase, FORMIC ACID | | Authors: | Zhang, X, Wang, L, Xu, X, Xing, X, Zhou, J. | | Deposit date: | 2022-08-12 | | Release date: | 2022-12-14 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Characterization and structural basis of D-cysteine desulfhydrase from Pectobacterium atrosepticum
Tetrahedron, 2022
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8XJN
 | | Cloprosetnol bound Thromboxane A2 receptor-Gq Protein Complex | | Descriptor: | Antibody fragment scFv16, Cloprostenol, Engineered miniGq, ... | | Authors: | Zhang, X, Li, X, Liu, G, Gong, W. | | Deposit date: | 2023-12-21 | | Release date: | 2024-02-28 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
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8XJL
 | | PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex | | Descriptor: | (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | | Authors: | Zhang, X, Li, X, Liu, G, Gong, W. | | Deposit date: | 2023-12-21 | | Release date: | 2024-02-28 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
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