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Influenza A/H17N10 polymerase with bound promoter and 3' end of template in active site
Descriptor:	3' end of the promoter vRNA, 5' end of the promoter vRNA, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:	Cusack, S, Drncova, P.
Deposit date:	2024-04-23
Release date:	2024-09-18
Method:	X-RAY DIFFRACTION (1.959 Å)
Cite:	High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit To Be Published

9F37

Replication-like initiation state of influenza polymerase with GTP and CTP at respectively the -1 and +1 positions (strain A/little yellow-shouldered bat/Guatemala/060/2010/H17N10)
Descriptor:	3' end of the vRNA promoter, 5' end of the vRNA promoter, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:	Cusack, S, Drncova, P.
Deposit date:	2024-04-25
Release date:	2024-09-18
Method:	X-RAY DIFFRACTION (1.905 Å)
Cite:	High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit Biorxiv, 2024

6QCX

Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer
Descriptor:	MAGNESIUM ION, PHOSPHATE ION, PYROPHOSPHATE 2-, ...
Authors:	Cusack, S, Drncova, P.
Deposit date:	2018-12-31
Release date:	2019-06-05
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (3.08 Å)
Cite:	Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019

6QCV

Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP
Descriptor:	CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:	Cusack, S, Drncova, P.
Deposit date:	2018-12-31
Release date:	2019-06-05
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (3.24 Å)
Cite:	Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019

6QCW

Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer
Descriptor:	PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:	Cusack, S, Drncova, P.
Deposit date:	2018-12-31
Release date:	2019-06-05
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.88 Å)
Cite:	Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019

7Z43

Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B
Descriptor:	PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:	Cusack, S, Drncova, P.
Deposit date:	2022-03-03
Release date:	2022-05-11
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (3.123 Å)
Cite:	Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD. Plos Pathog., 18, 2022

7Z42

Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 2B
Descriptor:	DNA-directed RNA polymerase II subunit RPB1, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:	Cusack, S, Drncova, P.
Deposit date:	2022-03-03
Release date:	2022-05-18
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (2.418 Å)
Cite:	Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD. Plos Pathog., 18, 2022

7R0E

Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-02-01
Release date:	2022-12-28
Last modified:	2024-07-17
Method:	ELECTRON MICROSCOPY (2.51 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

7R1F

Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-02-02
Release date:	2022-12-28
Last modified:	2024-07-17
Method:	ELECTRON MICROSCOPY (2.58 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

7QTL

Influenza A/H7N9 polymerase elongation complex
Descriptor:	3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-01-14
Release date:	2022-12-28
Last modified:	2024-07-17
Method:	ELECTRON MICROSCOPY (2.48 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BE0

Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the C +1 position
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-20
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (2.34 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BDR

Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-19
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (2.7 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BEK

Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-21
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (2.86 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BF5

Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP analogue
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-24
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (2.96 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

6FHH

Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated.
Descriptor:	PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:	Lukarska, M, Cusack, S.
Deposit date:	2018-01-14
Release date:	2019-01-30
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain To Be Published

6FHI

Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated Pol II CTD peptide with a truncated linker.
Descriptor:	PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:	Lukarska, M, Cusack, S.
Deposit date:	2018-01-14
Release date:	2019-01-30
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain To Be Published

7ZPM

Influenza A/H7N9 polymerase apo-protein dimer complex
Descriptor:	Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-04-27
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (2.81 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

7ZPL

Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook
Descriptor:	5' vRNA, MAGNESIUM ION, Polymerase acidic protein, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-04-27
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (3.12 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

6QCT

Influenza B polymerase elongation complex
Descriptor:	3 end, 5 end, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2018-12-30
Release date:	2019-06-05
Last modified:	2024-05-15
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019

6QCS

Influenza B polymerase pre-initiation complex
Descriptor:	3 end, 5 end, Capped RNA, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2018-12-30
Release date:	2019-06-05
Last modified:	2024-05-15
Method:	ELECTRON MICROSCOPY (3.1 Å)
Cite:	Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019

7Z4O

Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A
Descriptor:	MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:	Cusack, S, Pflug, A.
Deposit date:	2022-03-04
Release date:	2022-05-11
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (3.412 Å)
Cite:	Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD. Plos Pathog., 18, 2022

6SZV

Bat Influenza A polymerase elongation complex with incoming UTP analogue (core + endonuclease only)
Descriptor:	3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ...
Authors:	Wandzik, J.M, Kouba, T, Cusack, S.
Deposit date:	2019-10-02
Release date:	2020-04-15
Last modified:	2024-05-22
Method:	ELECTRON MICROSCOPY (2.5 Å)
Cite:	A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020

6T0U

Bat Influenza A polymerase product dissociation complex using 44-mer vRNA template with intact oligo(U) sequence
Descriptor:	Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit, ...
Authors:	Wandzik, J.M, Kouba, T, Cusack, S.
Deposit date:	2019-10-03
Release date:	2020-04-15
Last modified:	2024-09-25
Method:	ELECTRON MICROSCOPY (3.12 Å)
Cite:	A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020

6T0V

Bat Influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase)
Descriptor:	3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ...
Authors:	Wandzik, J.M, Kouba, T, Cusack, S.
Deposit date:	2019-10-03
Release date:	2020-04-15
Last modified:	2024-05-22
Method:	ELECTRON MICROSCOPY (3.02 Å)
Cite:	A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020

6T0W

Human Influenza B polymerase recycling complex
Descriptor:	Polymerase PB2, Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, ...
Authors:	Wandzik, J.M, Kouba, T, Karuppasamy, M, Cusack, S.
Deposit date:	2019-10-03
Release date:	2020-04-15
Last modified:	2024-05-22
Method:	ELECTRON MICROSCOPY (3.18 Å)
Cite:	A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020

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Displayed results:	25
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