2Y1N
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![BU of 2y1n by Molmil](/molmil-images/mine/2y1n) | Structure of c-Cbl-ZAP-70 peptide complex | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, ... | Authors: | Dou, H, Sibbet, G.J, Huang, D.T. | Deposit date: | 2010-12-08 | Release date: | 2012-01-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.999 Å) | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat.Struct.Mol.Biol., 19, 2012
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2Y1M
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![BU of 2y1m by Molmil](/molmil-images/mine/2y1m) | Structure of native c-Cbl | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION | Authors: | Dou, H, Sibbet, G.J, Huang, D.T. | Deposit date: | 2010-12-08 | Release date: | 2012-01-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat.Struct.Mol.Biol., 19, 2012
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3ZNI
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![BU of 3zni by Molmil](/molmil-images/mine/3zni) | Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL-B, ... | Authors: | Dou, H, Buetow, L, Sibbet, G.J, Cameron, K, Huang, D.T. | Deposit date: | 2013-02-14 | Release date: | 2013-07-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Essentiality of a Non-Ring Element in Priming Donor Ubiquitin for Catalysis by a Monomeric E3. Nat.Struct.Mol.Biol., 20, 2013
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4A4B
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![BU of 4a4b by Molmil](/molmil-images/mine/4a4b) | Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ... | Authors: | Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T. | Deposit date: | 2011-10-08 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.789 Å) | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl Nat.Struct.Mol.Biol., 19, 2012
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4A4C
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![BU of 4a4c by Molmil](/molmil-images/mine/4a4c) | Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ... | Authors: | Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T. | Deposit date: | 2011-10-08 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.704 Å) | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl Nat.Struct.Mol.Biol., 19, 2012
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4AUQ
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![BU of 4auq by Molmil](/molmil-images/mine/4auq) | Structure of BIRC7-UbcH5b-Ub complex. | Descriptor: | BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 7, POLYUBIQUITIN-C, UBIQUITIN-CONJUGATING ENZYME E2 D2, ... | Authors: | Dou, H, Buetow, L, Sibbet, G.J, Cameron, K, Huang, D.T. | Deposit date: | 2012-05-21 | Release date: | 2012-08-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.176 Å) | Cite: | Birc7-E2 Ubiquitin Conjugate Structure Reveals the Mechanism of Ubiquitin Transfer by a Ring Dimer. Nat.Struct.Mol.Biol., 19, 2012
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4A49
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![BU of 4a49 by Molmil](/molmil-images/mine/4a49) | Structure of phosphoTyr371-c-Cbl-UbcH5B complex | Descriptor: | E3 ubiquitin-protein ligase CBL, POTASSIUM ION, Ubiquitin-conjugating enzyme E2 D2, ... | Authors: | Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T. | Deposit date: | 2011-10-07 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.214 Å) | Cite: | Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl. Nat. Struct. Mol. Biol., 19, 2012
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4V3K
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![BU of 4v3k by Molmil](/molmil-images/mine/4v3k) | RNF38-UbcH5B-UB complex | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ... | Authors: | Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T. | Deposit date: | 2014-10-20 | Release date: | 2015-04-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin. Mol.Cell, 58, 2015
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4V3L
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![BU of 4v3l by Molmil](/molmil-images/mine/4v3l) | RNF38-UB-UbcH5B-Ub complex | Descriptor: | 1,2-ETHANEDIOL, E3 UBIQUITIN-PROTEIN LIGASE RNF38, POLYUBIQUITIN-C, ... | Authors: | Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T. | Deposit date: | 2014-10-20 | Release date: | 2015-04-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin. Mol.Cell, 58, 2015
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1FB9
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![BU of 1fb9 by Molmil](/molmil-images/mine/1fb9) | |
5J3X
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![BU of 5j3x by Molmil](/molmil-images/mine/5j3x) | Structure of c-CBL Y371F | Descriptor: | CALCIUM ION, E3 ubiquitin-protein ligase CBL, ZINC ION | Authors: | Huang, D.T, Buetow, L, Dou, H. | Deposit date: | 2016-03-31 | Release date: | 2016-09-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.822 Å) | Cite: | Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation. Bmc Biol., 14, 2016
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1IOX
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![BU of 1iox by Molmil](/molmil-images/mine/1iox) | NMR Structure of human Betacellulin-2 | Descriptor: | Betacellulin | Authors: | Miura, K, Doura, H, Aizawa, T, Tada, H, Seno, M, Yamada, H, Kawano, K. | Deposit date: | 2001-04-18 | Release date: | 2002-07-24 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of betacellulin, a new member of EGF-family ligands. Biochem.Biophys.Res.Commun., 294, 2002
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1JH3
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![BU of 1jh3 by Molmil](/molmil-images/mine/1jh3) | Solution structure of tyrosyl-tRNA synthetase C-terminal domain. | Descriptor: | TYROSYL-TRNA SYNTHETASE | Authors: | Guijarro, J.I, Pintar, A, Prochnicka-Chalufour, A, Guez, V, Gilquin, B, Bedouelle, H, Delepierre, M. | Deposit date: | 2001-06-27 | Release date: | 2002-03-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure and Dynamics of the Anticodon Arm Binding Domain of Bacillus stearothermophilus
Tyrosyl-tRNA Synthetase Structure, 10, 2002
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1IP0
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![BU of 1ip0 by Molmil](/molmil-images/mine/1ip0) | NMR STRUCTURE OF HUMAN BETACELLULIN-2 | Descriptor: | BETACELLULIN | Authors: | Miura, K, Doura, H, Aizawa, T, Tada, H, Seno, M, Yamada, H, Kawano, K. | Deposit date: | 2001-04-19 | Release date: | 2002-07-31 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of betacellulin, a new member of EGF-family ligands. Biochem.Biophys.Res.Commun., 294, 2002
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2WJ8
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![BU of 2wj8 by Molmil](/molmil-images/mine/2wj8) | Respiratory Syncitial Virus RiboNucleoProtein | Descriptor: | BORATE ION, NUCLEOPROTEIN, RNA (5'-R(*CP*CP*CP*CP*CP*C)-3') | Authors: | Tawar, R.G, Duquerroy, S, Vonrhein, C, Varela, P.F, Damier-Piolle, L, Castagne, N, MacLellan, K, Bedouelle, H, Bricogne, G, Bhella, D, Eleouet, J, Rey, F.A. | Deposit date: | 2009-05-25 | Release date: | 2009-12-08 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus Science, 326, 2009
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3UYP
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![BU of 3uyp by Molmil](/molmil-images/mine/3uyp) | Crystal structure of the dengue virus serotype 4 envelope protein domain III in complex with the variable domains of Mab 4E11 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Envelope protein, GLYCEROL, ... | Authors: | Cockburn, J.J.B, Navarro Sanchez, M.E, Fretes, N, Urvoas, A, Staropoli, I, Kikuti, C.M, Coffey, L.L, Arenzana Seisdedos, F, Bedouelle, H, Rey, F.A. | Deposit date: | 2011-12-06 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody. Structure, 20, 2012
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3UZE
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![BU of 3uze by Molmil](/molmil-images/mine/3uze) | Crystal structure of the dengue virus serotype 3 envelope protein domain III in complex with the variable domains of Mab 4E11 | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Envelope protein, ... | Authors: | Cockburn, J.J.B, Navarro Sanchez, M.E, Fretes, N, Urvoas, A, Staropoli, I, Kikuti, C.M, Coffey, L.L, Arenzana Seisdedos, F, Bedouelle, H, Rey, F.A. | Deposit date: | 2011-12-07 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody. Structure, 20, 2012
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3UZV
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![BU of 3uzv by Molmil](/molmil-images/mine/3uzv) | Crystal structure of the dengue virus serotype 2 envelope protein domain III in complex with the variable domains of Mab 4E11 | Descriptor: | ETHANOL, anti-dengue Mab 4E11, envelope protein | Authors: | Cockburn, J.J.B, Navarro Sanchez, M.E, Fretes, N, Urvoas, A, Staropoli, I, Kikuti, C.M, Coffey, L.L, Arenzana Seisdedos, F, Bedouelle, H, Rey, F.A. | Deposit date: | 2011-12-07 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody. Structure, 20, 2012
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3UZQ
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![BU of 3uzq by Molmil](/molmil-images/mine/3uzq) | Crystal structure of the dengue virus serotype 1 envelope protein domain III in complex with the variable domains of Mab 4E11 | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ... | Authors: | Cockburn, J.J.B, Navarro Sanchez, M.E, Fretes, N, Urvoas, A, Staropoli, I, Kikuti, C.M, Coffey, L.L, Arenzana Seisdedos, F, Bedouelle, H, Rey, F.A. | Deposit date: | 2011-12-07 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody. Structure, 20, 2012
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1ODD
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![BU of 1odd by Molmil](/molmil-images/mine/1odd) | |
6UD2
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![BU of 6ud2 by Molmil](/molmil-images/mine/6ud2) | co-crystal structure of compound 1 bound to human Mcl-1 | Descriptor: | (4S,7aR,9aR,10S,11E,18R)-6'-chloro-10-[2-(3,3-difluoroazetidin-1-yl)ethoxy]-N-(dimethylsulfamoyl)-18-hydroxy-15-methyl-16-oxo-3',4',7,7a,8,9,9a,10,13,14,15,16,17,18-tetradecahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)cyclobuta[n][1,4]oxazepino[4,3-a][1,8]diazacyclohexadecine-4,1'-naphthalene]-18-carboxamide, Induced myeloid leukemia cell differentiation protein Mcl-1 | Authors: | Huang, X, Whittington, D. | Deposit date: | 2019-09-18 | Release date: | 2019-12-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an alpha-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere. J.Med.Chem., 62, 2019
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8B12
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![BU of 8b12 by Molmil](/molmil-images/mine/8b12) | cryo-EM structure of carboxysomal mini-shell: icosahedral assembly from CsoS4A/1A and CsoS2 co-expression (T = 9) | Descriptor: | Carboxysome assembly protein CsoS2B, Carboxysome shell vertex protein CsoS4A, Major carboxysome shell protein CsoS1A | Authors: | Ni, T, Jiang, Q, Liu, L.N, Zhang, P. | Deposit date: | 2022-09-09 | Release date: | 2023-08-23 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (1.86 Å) | Cite: | Intrinsically disordered CsoS2 acts as a general molecular thread for alpha-carboxysome shell assembly. Nat Commun, 14, 2023
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8B0Y
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![BU of 8b0y by Molmil](/molmil-images/mine/8b0y) | cryo-EM structure of carboxysomal mini-shell: icosahedral assembly from CsoS4A/1A co-expression (T = 3) | Descriptor: | Carboxysome shell vertex protein CsoS4A, Major carboxysome shell protein CsoS1A | Authors: | Ni, T, Jiang, Q, Liu, L.N, Zhang, P. | Deposit date: | 2022-09-08 | Release date: | 2023-08-23 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Intrinsically disordered CsoS2 acts as a general molecular thread for alpha-carboxysome shell assembly. Nat Commun, 14, 2023
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8B11
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![BU of 8b11 by Molmil](/molmil-images/mine/8b11) | cryo-EM structure of carboxysomal mini-shell: icosahedral assembly from CsoS4A/1A and CsoS2 co-expression (T = 4) | Descriptor: | Carboxysome shell vertex protein CsoS4A, Major carboxysome shell protein CsoS1A | Authors: | Ni, T, Jiang, Q, Liu, L.N, Zhang, P. | Deposit date: | 2022-09-08 | Release date: | 2023-08-23 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | Intrinsically disordered CsoS2 acts as a general molecular thread for alpha-carboxysome shell assembly. Nat Commun, 14, 2023
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6LJS
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![BU of 6ljs by Molmil](/molmil-images/mine/6ljs) | Crystal structure of human FABP4 in complex with a novel inhibitor | Descriptor: | 1,2-ETHANEDIOL, 2-[(2-phenylphenyl)amino]benzoic acid, Fatty acid-binding protein, ... | Authors: | Su, H.X, Zhang, X.L, Li, M.J, Xu, Y.C. | Deposit date: | 2019-12-17 | Release date: | 2020-04-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation. J.Med.Chem., 63, 2020
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