3UZV

Crystal structure of the dengue virus serotype 2 envelope protein domain III in complex with the variable domains of Mab 4E11

Summary for 3UZV

• Entry DOI: 10.2210/pdb3uzv/pdb
• Related: 3UYP 3UZE 3UZQ
• Descriptor: envelope protein, anti-dengue Mab 4E11, ETHANOL, ... (4 entities in total)
• Functional Keywords: dengue antibody neutralization, immune system
• Biological source: Dengue virus 2 (DENV-2); More
• Cellular location: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P07564
• Total number of polymer chains: 2
• Total formula weight: 40159.09

Authors

Cockburn, J.J.B.,Navarro Sanchez, M.E.,Fretes, N.,Urvoas, A.,Staropoli, I.,Kikuti, C.M.,Coffey, L.L.,Arenzana Seisdedos, F.,Bedouelle, H.,Rey, F.A. (deposition date: 2011-12-07, release date: 2012-02-22, Last modification date: 2023-09-13)

• Primary citation: Cockburn, J.J.,Navarro Sanchez, M.E.,Fretes, N.,Urvoas, A.,Staropoli, I.,Kikuti, C.M.,Coffey, L.L.,Arenzana Seisdedos, F.,Bedouelle, H.,Rey, F.A.; Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody.; Structure, 20:303-314, 2012; PubMed: 22285214; DOI: 10.1016/j.str.2012.01.001

Experimental method

X-RAY DIFFRACTION (2.1 Å)