2OG9
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6TI7
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![BU of 6ti7 by Molmil](/molmil-images/mine/6ti7) | Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils | Descriptor: | Amyloid-beta precursor protein | Authors: | Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. | Deposit date: | 2019-11-21 | Release date: | 2020-07-22 | Last modified: | 2024-06-19 | Method: | SOLID-STATE NMR | Cite: | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils. Chem.Commun.(Camb.), 56, 2020
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6T1J
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![BU of 6t1j by Molmil](/molmil-images/mine/6t1j) | Crystal structure of MLLT1 (ENL) YEATS domain in complexed with piperazine-urea derivative 2 | Descriptor: | 1,2-ETHANEDIOL, Protein ENL, ~{N}-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-4-thiophen-2-ylcarbonyl-piperazine-1-carboxamide | Authors: | Chaikuad, A, Heidenreich, D, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Fedorov, O, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2019-10-04 | Release date: | 2019-11-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1. Acs Med.Chem.Lett., 10, 2019
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2NY6
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![BU of 2ny6 by Molmil](/molmil-images/mine/2ny6) | HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T123C, T257S, V275C,S334A, S375W, Q428C, G431C) Complexed with CD4 and Antibody 17b | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ... | Authors: | Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D. | Deposit date: | 2006-11-20 | Release date: | 2007-02-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature, 445, 2007
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2OHF
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3JYO
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![BU of 3jyo by Molmil](/molmil-images/mine/3jyo) | Quinate dehydrogenase from Corynebacterium glutamicum in complex with NAD | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Quinate/shikimate dehydrogenase | Authors: | Hoeppner, A, Niefind, K, Schomburg, D. | Deposit date: | 2009-09-22 | Release date: | 2010-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Enzyme-substrate complexes of the quinate/shikimate dehydrogenase from Corynebacterium glutamicum enable new insights in substrate and cofactor binding, specificity, and discrimination. Biol.Chem., 394, 2013
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3CFO
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![BU of 3cfo by Molmil](/molmil-images/mine/3cfo) | Triple Mutant APO structure | Descriptor: | DNA polymerase, GUANOSINE, SULFATE ION | Authors: | Wang, J, Klimenko, D, Wang, M, Steitz, T.A, Konigsberg, W.H. | Deposit date: | 2008-03-04 | Release date: | 2009-03-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Insights into base selectivity from the structures
of an RB69 DNA Polymerase triple mutant To be Published
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6TAY
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![BU of 6tay by Molmil](/molmil-images/mine/6tay) | Mouse RNF213 mutant R4753K modeling the Moyamoya-disease-related Human variant R4810K | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNF213,E3 ubiquitin-protein ligase RNF213,E3 ubiquitin-protein ligase RNF213, ... | Authors: | Ahel, J, Meinhart, A, Haselbach, D, Clausen, T. | Deposit date: | 2019-10-31 | Release date: | 2020-07-01 | Last modified: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism. Elife, 9, 2020
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2OIZ
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6T9C
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2NS9
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![BU of 2ns9 by Molmil](/molmil-images/mine/2ns9) | Crystal structure of protein APE2225 from Aeropyrum pernix K1, Pfam COXG | Descriptor: | Hypothetical protein APE2225, PHOSPHATE ION | Authors: | Jin, X, Bera, A, Wasserman, S, Smith, D, Sauder, J.M, Burley, S.K, Shapiro, L, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2006-11-03 | Release date: | 2006-11-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of hypothetical protein APE2225 from Aeropyrum pernix K1 To be Published
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2O0Q
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![BU of 2o0q by Molmil](/molmil-images/mine/2o0q) | X-ray Crystal Structure of Protein CC0527 from Caulobacter crescentus. Northeast Structural Genomics Consortium Target CcR55 | Descriptor: | Hypothetical protein CC0527 | Authors: | Seetharaman, J, Su, M, Wang, D, Fang, Y, Cunningham, K, Ma, L, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-11-28 | Release date: | 2006-12-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the Hypothetical Protein from Caulobacter Crescentus. TO BE PUBLISHED
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6TAC
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![BU of 6tac by Molmil](/molmil-images/mine/6tac) | Human NAMPT deletion mutant in complex with nicotinamide mononucleotide, pyrophosphate, and Mg2+ | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | Deposit date: | 2019-10-29 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Identification of structural determinants of NAMPT activity and substrate selectivity To Be Published
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6TD7
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![BU of 6td7 by Molmil](/molmil-images/mine/6td7) | Structure of truncated hemoglobin THB11 from Chlamydomonas reinhardtii | Descriptor: | CYANIDE ION, PROTOPORPHYRIN IX CONTAINING FE, THB11 | Authors: | Huwald, D, Gasper, R, Hemschemeier, A, Hofmann, E. | Deposit date: | 2019-11-08 | Release date: | 2020-02-26 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Distinctive structural properties of THB11, a pentacoordinate Chlamydomonas reinhardtii truncated hemoglobin with N- and C-terminal extensions. J.Biol.Inorg.Chem., 25, 2020
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2O2C
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![BU of 2o2c by Molmil](/molmil-images/mine/2o2c) | Crystal structure of phosphoglucose isomerase from T. brucei containing glucose-6-phosphate in the active site | Descriptor: | GLUCOSE-6-PHOSPHATE, GLYCEROL, Glucose-6-phosphate isomerase, ... | Authors: | Arsenieva, D, Mazock, G.H, Appavu, B.L, Jeffery, C.J. | Deposit date: | 2006-11-29 | Release date: | 2007-11-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Crystal structure of phosphoglucose isomerase from Trypanosoma brucei complexed with glucose-6-phosphate at 1.6 A resolution Proteins, 74, 2008
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3CLB
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![BU of 3clb by Molmil](/molmil-images/mine/3clb) | Structure of bifunctional TcDHFR-TS in complex with TMQ | Descriptor: | 1,2-ETHANEDIOL, DHFR-TS, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Schormann, N, Senkovich, O, Chattopadhyay, D. | Deposit date: | 2008-03-18 | Release date: | 2009-01-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function. Proteins, 73, 2008
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3CMR
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![BU of 3cmr by Molmil](/molmil-images/mine/3cmr) | E. coli alkaline phosphatase mutant R166S in complex with phosphate | Descriptor: | Alkaline phosphatase, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | O'Brien, P.J, Lassila, J.K, Fenn, T.D, Zalatan, J.G, Herschlag, D. | Deposit date: | 2008-03-24 | Release date: | 2008-07-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Arginine coordination in enzymatic phosphoryl transfer: evaluation of the effect of Arg166 mutations in Escherichia coli alkaline phosphatase Biochemistry, 47, 2008
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3J68
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![BU of 3j68 by Molmil](/molmil-images/mine/3j68) | Structural mechanism of the dynein powerstroke (pre-powerstroke state) | Descriptor: | Dynein motor domain | Authors: | Lin, J, Okada, K, Raytchev, M, Smith, M.C, Nicastro, D. | Deposit date: | 2013-12-23 | Release date: | 2014-04-23 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (30 Å) | Cite: | Structural mechanism of the dynein power stroke. Nat.Cell Biol., 16, 2014
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3ZGB
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![BU of 3zgb by Molmil](/molmil-images/mine/3zgb) | Greater efficiency of photosynthetic carbon fixation due to single amino acid substitution | Descriptor: | 1,2-ETHANEDIOL, ASPARTIC ACID, PHOSPHOENOLPYRUVATE CARBOXYLASE, ... | Authors: | Paulus, J.K, Schlieper, D, Groth, G. | Deposit date: | 2012-12-17 | Release date: | 2013-02-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Greater Efficiency of Photosynthetic Carbon Fixation due to Single Amino Acid Substitution Nat.Commun., 4, 2013
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2NWA
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![BU of 2nwa by Molmil](/molmil-images/mine/2nwa) | X-ray Crystal Structure of Protein ytmB from Bacillus subtilis. Northeast Structural Genomics Consortium Target SR466 | Descriptor: | Hypothetical protein ytmB, SULFATE ION | Authors: | Zhou, W, Forouhar, F, Seetharaman, J, Wang, D, Cunningham, K, Ma, L.-C, Fang, Y, Xiao, R, Baran, M.C, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-11-14 | Release date: | 2007-01-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structure of the Hypothetical protein YtmB from Bacillus subtilis subsp. (subtilis str. 168), Northeast Structural Genomics target SR466 To be Published
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1FRQ
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![BU of 1frq by Molmil](/molmil-images/mine/1frq) | FERREDOXIN:NADP+ OXIDOREDUCTASE (FERREDOXIN REDUCTASE) MUTANT E312A | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, PHOSPHATE ION, PROTEIN (FERREDOXIN:NADP+ OXIDOREDUCTASE), ... | Authors: | Aliverti, A, Deng, Z, Ravasi, D, Piubelli, L, Karplus, P.A, Zanetti, G. | Deposit date: | 1998-10-10 | Release date: | 1998-10-14 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Probing the function of the invariant glutamyl residue 312 in spinach ferredoxin-NADP+ reductase. J.Biol.Chem., 273, 1998
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3ZLL
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![BU of 3zll by Molmil](/molmil-images/mine/3zll) | Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-azanyl-6-oxidanyl-1-(phenylmethyl)pyrimidine-2,4-dione, CHLORIDE ION, ... | Authors: | Alphey, M.S, Pirrie, L, Torrie, L.S, Gardiner, M, Sarkar, A, Brenk, R, Westwood, N.J, Gray, D, Naismith, J.H. | Deposit date: | 2013-02-01 | Release date: | 2013-02-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa. ACS Chem. Biol., 8, 2013
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6T1L
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![BU of 6t1l by Molmil](/molmil-images/mine/6t1l) | Crystal structure of MLLT1 (ENL) YEATS domain in complexed with piperazine-urea derivative 3 | Descriptor: | 1,2-ETHANEDIOL, Protein ENL, ~{N}-[[4-(diethylaminomethyl)phenyl]methyl]-4-pyrimidin-2-yl-piperazine-1-carboxamide | Authors: | Chaikuad, A, Heidenreich, D, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Fedorov, O, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2019-10-04 | Release date: | 2019-11-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1. Acs Med.Chem.Lett., 10, 2019
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3J9G
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![BU of 3j9g by Molmil](/molmil-images/mine/3j9g) | Atomic model of the VipA/VipB, the type six secretion system contractile sheath of Vibrio cholerae from cryo-EM | Descriptor: | VipA, VipB | Authors: | Kudryashev, M, Wang, R.Y.-R, Brackmann, M, Scherer, S, Maier, T, Baker, D, DiMaio, F, Stahlberg, H, Egelman, E.H, Basler, M. | Deposit date: | 2015-01-16 | Release date: | 2015-03-11 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the Type VI Secretion System Contractile Sheath. Cell(Cambridge,Mass.), 160, 2015
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6T3A
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![BU of 6t3a by Molmil](/molmil-images/mine/6t3a) | Difference-refined structure of rsEGFP2 10 ns following 400-nm laser irradiation of the off-state determined by SFX | Descriptor: | Green fluorescent protein | Authors: | Woodhouse, J, Coquelle, N, Adam, V, Barends, T.R.M, De La Mora, E, Bourgeois, D, Colletier, J.P, Schlichting, I, Weik, M. | Deposit date: | 2019-10-10 | Release date: | 2020-02-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Photoswitching mechanism of a fluorescent protein revealed by time-resolved crystallography and transient absorption spectroscopy. Nat Commun, 11, 2020
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