6DJP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6djp by Molmil](/molmil-images/mine/6djp) | Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 68 heavy chain Fab, ... | Authors: | Cormier, A, Campbell, M.G, Nishimura, S.L, Cheng, Y. | Deposit date: | 2018-05-25 | Release date: | 2018-07-25 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Cryo-EM structure of the alpha v beta 8 integrin reveals a mechanism for stabilizing integrin extension. Nat. Struct. Mol. Biol., 25, 2018
|
|
7CSV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7csv by Molmil](/molmil-images/mine/7csv) | Pseudomonas aeruginosa antitoxin HigA | Descriptor: | HTH cro/C1-type domain-containing protein | Authors: | Song, Y.J, Luo, G.H, Bao, R. | Deposit date: | 2020-08-17 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Pseudomonas aeruginosa antitoxin HigA functions as a diverse regulatory factor by recognizing specific pseudopalindromic DNA motifs. Environ.Microbiol., 23, 2021
|
|
5Z8Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5z8q by Molmil](/molmil-images/mine/5z8q) | |
7CSY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7csy by Molmil](/molmil-images/mine/7csy) | Pseudomonas aeruginosa antitoxin HigA with higBA promoter | Descriptor: | DNA (28-MER), DNA (29-MER), HTH cro/C1-type domain-containing protein, ... | Authors: | Song, Y.J, Luo, G.H, Bao, R. | Deposit date: | 2020-08-17 | Release date: | 2021-01-13 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Pseudomonas aeruginosa antitoxin HigA functions as a diverse regulatory factor by recognizing specific pseudopalindromic DNA motifs. Environ.Microbiol., 23, 2021
|
|
7CF9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cf9 by Molmil](/molmil-images/mine/7cf9) | Structure of RyR1 (Ca2+/CHL) | Descriptor: | 5-bromanyl-N-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | Authors: | Ma, R, Haji-Ghassemi, O, Ma, D, Lin, L, Samurkas, A, Van Petegem, F, Yuchi, Z. | Deposit date: | 2020-06-24 | Release date: | 2020-09-02 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structural basis for diamide modulation of ryanodine receptor. Nat.Chem.Biol., 16, 2020
|
|
1IHS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ihs by Molmil](/molmil-images/mine/1ihs) | |
1IHT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1iht by Molmil](/molmil-images/mine/1iht) | |
2P3U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p3u by Molmil](/molmil-images/mine/2p3u) | |
7JQC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7jqc by Molmil](/molmil-images/mine/7jqc) | SARS-CoV-2 Nsp1, CrPV IRES and rabbit 40S ribosome complex | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ... | Authors: | Yuan, S, Xiong, Y. | Deposit date: | 2020-08-10 | Release date: | 2020-12-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. Mol.Cell, 80, 2020
|
|
6LKA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lka by Molmil](/molmil-images/mine/6lka) | Crystal Structure of EV71-3C protease with a Novel Macrocyclic Compounds | Descriptor: | 3C proteinase, ~{N}-[(2~{S})-1-[[(2~{S},3~{S},6~{S},7~{Z},12~{E})-4,9-bis(oxidanylidene)-6-[[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]methyl]-2-phenyl-1,10-dioxa-5-azacyclopentadeca-7,12-dien-3-yl]amino]-3-methyl-1-oxidanylidene-butan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide | Authors: | Li, P, Wu, S.Q, Xiao, T.Y.C, Li, Y.L, Su, Z.M, Hao, F, Hu, G.P, Hu, J, Lin, F.S, Chen, X.S, Gu, Z.X, He, H.Y, Li, J, Chen, S.H. | Deposit date: | 2019-12-18 | Release date: | 2020-06-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.033 Å) | Cite: | Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent. Bioorg.Med.Chem., 28, 2020
|
|
7JQB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7jqb by Molmil](/molmil-images/mine/7jqb) | SARS-CoV-2 Nsp1 and rabbit 40S ribosome complex | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ... | Authors: | Yuan, S, Xiong, Y. | Deposit date: | 2020-08-10 | Release date: | 2020-12-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. Mol.Cell, 80, 2020
|
|
7BR2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7br2 by Molmil](/molmil-images/mine/7br2) | |
1AF0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1af0 by Molmil](/molmil-images/mine/1af0) | SERRATIA PROTEASE IN COMPLEX WITH INHIBITOR | Descriptor: | CALCIUM ION, N-[(benzyloxy)carbonyl]-L-leucyl-N-hydroxy-L-alaninamide, SERRATIA PROTEASE, ... | Authors: | Baumann, U. | Deposit date: | 1997-03-20 | Release date: | 1998-03-25 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the 50 kDa Metallo Protease from S. Marcescens in Complex with the Synthetic Inhibitor Cbz-Leu-Ala-Nhoh To be Published
|
|
8IOY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ioy by Molmil](/molmil-images/mine/8ioy) | Structure of ATP7B C983S/C985S/D1027A mutant with AMP-PNP | Descriptor: | Copper-transporting ATPase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Yang, G, Xu, L, Guo, J, Wu, Z. | Deposit date: | 2023-03-13 | Release date: | 2023-04-26 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures of the human Wilson disease copper transporter ATP7B. Cell Rep, 42, 2023
|
|
4HBN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hbn by Molmil](/molmil-images/mine/4hbn) | Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PHOSPHATE ION, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Authors: | Xu, X, Marni, F, Wu, X, Su, Z, Musayev, F, Shrestha, S, Xie, C, Gao, W, Liu, Q, Zhou, L. | Deposit date: | 2012-09-28 | Release date: | 2013-01-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Local and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel. Structure, 20, 2012
|
|
4WTR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wtr by Molmil](/molmil-images/mine/4wtr) | Active-site mutant of Rhizomucor miehei beta-1,3-glucanosyltransferase in complex with laminaribiose | Descriptor: | beta-1,3-glucanosyltransferase, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose | Authors: | Qin, Z, Yan, Q, Lei, J, Yang, S, Jiang, Z. | Deposit date: | 2014-10-30 | Release date: | 2015-08-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | The first crystal structure of a glycoside hydrolase family 17 beta-1,3-glucanosyltransferase displays a unique catalytic cleft. Acta Crystallogr.,Sect.D, 71, 2015
|
|
4WTP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wtp by Molmil](/molmil-images/mine/4wtp) | Crystal structure of glycoside hydrolase family 17 beta-1,3-glucanosyltransferase from Rhizomucor miehei | Descriptor: | 1,2-ETHANEDIOL, beta-1,3-glucanosyltransferase | Authors: | Qin, Z, Yan, Q, Lei, J, Yang, S, Jiang, Z. | Deposit date: | 2014-10-30 | Release date: | 2015-08-12 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The first crystal structure of a glycoside hydrolase family 17 beta-1,3-glucanosyltransferase displays a unique catalytic cleft. Acta Crystallogr.,Sect.D, 71, 2015
|
|
4WTS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wts by Molmil](/molmil-images/mine/4wts) | Active-site mutant of Rhizomucor miehei beta-1,3-glucanosyltransferase in complex with laminaritriose | Descriptor: | beta-1,3-glucanosyltransferase, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose | Authors: | Qin, Z, Yan, Q, Lei, J, Yang, S, Jiang, Z. | Deposit date: | 2014-10-30 | Release date: | 2015-08-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The first crystal structure of a glycoside hydrolase family 17 beta-1,3-glucanosyltransferase displays a unique catalytic cleft. Acta Crystallogr.,Sect.D, 71, 2015
|
|
3KDU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3kdu by Molmil](/molmil-images/mine/3kdu) | |
3KDT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3kdt by Molmil](/molmil-images/mine/3kdt) | |
6U0D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6u0d by Molmil](/molmil-images/mine/6u0d) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZL0590 | Descriptor: | Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, N-[4-({(2S)-2-[(morpholin-4-yl)methyl]pyrrolidin-1-yl}sulfonyl)phenyl]-N'-[4-(trifluoromethyl)phenyl]urea | Authors: | Leonard, P.G, Joseph, S. | Deposit date: | 2019-08-14 | Release date: | 2020-08-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site J. Med. Chem., 2022
|
|
6SCT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sct by Molmil](/molmil-images/mine/6sct) | Cryo-EM structure of the consensus triskelion hub of the clathrin coat complex | Descriptor: | Clathrin heavy chain, Clathrin light chain | Authors: | Morris, K.L, Cameron, A.D, Sessions, R, Smith, C.J. | Deposit date: | 2019-07-25 | Release date: | 2019-10-02 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.69 Å) | Cite: | Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly. Nat.Struct.Mol.Biol., 26, 2019
|
|
8GU7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8gu7 by Molmil](/molmil-images/mine/8gu7) | |
8GT9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8gt9 by Molmil](/molmil-images/mine/8gt9) | |
8WGV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wgv by Molmil](/molmil-images/mine/8wgv) | BA.2(S375) Spike (S6P)/hACE2 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Wei, X, Zhang, Z. | Deposit date: | 2023-09-22 | Release date: | 2024-02-28 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. Nat.Immunol., 25, 2024
|
|