5XNF
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![BU of 5xnf by Molmil](/molmil-images/mine/5xnf) | Crystal structure of the branched-chain polyamine synthase (BpsA) from Thermococcus kodakarensis | Descriptor: | FE (III) ION, GLYCEROL, N(4)-bis(aminopropyl)spermidine synthase, ... | Authors: | Mizohata, E, Tse, K.M, Fujita, J, Inoue, T. | Deposit date: | 2017-05-22 | Release date: | 2018-08-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine. FEBS J., 284, 2017
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5XNH
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![BU of 5xnh by Molmil](/molmil-images/mine/5xnh) | Crystal structure of the branched-chain polyamine synthase (BpsA) in complex with spermidine | Descriptor: | FE (III) ION, N(4)-bis(aminopropyl)spermidine synthase, SPERMIDINE | Authors: | Mizohata, E, Tse, K.M, Fujita, J, Inoue, T. | Deposit date: | 2017-05-22 | Release date: | 2017-10-04 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine. FEBS J., 284, 2017
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5XNC
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![BU of 5xnc by Molmil](/molmil-images/mine/5xnc) | Crystal structure of the branched-chain polyamine synthase (BpsA) in complex with N4-aminopropylspermidine and 5-methylthioadenosine | Descriptor: | 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Mizohata, E, Tse, K.M, Fujita, J, Inoue, T. | Deposit date: | 2017-05-22 | Release date: | 2018-08-15 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine. FEBS J., 284, 2017
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6J26
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![BU of 6j26 by Molmil](/molmil-images/mine/6j26) | Crystal structure of the branched-chain polyamine synthase from Thermococcus kodakarensis (Tk-BpsA) in complex with N4-bis(aminopropyl)spermidine and 5'-methylthioadenosine | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, FE (III) ION, N(4)-bis(aminopropyl)spermidine synthase, ... | Authors: | Mizohata, E, Toyoda, M, Fujita, J, Inoue, T. | Deposit date: | 2018-12-31 | Release date: | 2019-06-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The C-terminal flexible region of branched-chain polyamine synthase facilitates substrate specificity and catalysis. Febs J., 286, 2019
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6J28
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![BU of 6j28 by Molmil](/molmil-images/mine/6j28) | Crystal structure of the branched-chain polyamine synthase C9 mutein from Thermus thermophilus (Tth-BpsA C9) in complex with N4-aminopropylspermidine and 5'-methylthioadenosine | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-DEOXY-5'-METHYLTHIOADENOSINE, FE (III) ION, ... | Authors: | Mizohata, E, Toyoda, M, Fujita, J, Inoue, T. | Deposit date: | 2018-12-31 | Release date: | 2019-06-26 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The C-terminal flexible region of branched-chain polyamine synthase facilitates substrate specificity and catalysis. Febs J., 286, 2019
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6KX8
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![BU of 6kx8 by Molmil](/molmil-images/mine/6kx8) | Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound | Descriptor: | 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-2 | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2019-09-10 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
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6KX5
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![BU of 6kx5 by Molmil](/molmil-images/mine/6kx5) | |
6KX7
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![BU of 6kx7 by Molmil](/molmil-images/mine/6kx7) | Crystal structure of mouse Cryptochrome 1 in complex with TH301 compound | Descriptor: | 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-1 | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2019-09-10 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
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6KX6
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![BU of 6kx6 by Molmil](/molmil-images/mine/6kx6) | Crystal structure of mouse Cryptochrome 1 in complex with KL101 compound | Descriptor: | Cryptochrome-1, ~{N}-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-benzamide | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2019-09-10 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
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6KX4
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![BU of 6kx4 by Molmil](/molmil-images/mine/6kx4) | |
7D1C
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![BU of 7d1c by Molmil](/molmil-images/mine/7d1c) | Crystal structure of mouse Cryptochrome 1 in complex with compound TH303 | Descriptor: | Cryptochrome-1, N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide | Authors: | Miller, S.A, Hirota, T. | Deposit date: | 2020-09-14 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J.Am.Chem.Soc., 143, 2021
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7D19
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6LUE
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![BU of 6lue by Molmil](/molmil-images/mine/6lue) | Crystal structure of mouse Cryptochrome 1 in complex with compound KL201 | Descriptor: | 2-bromanyl-N-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)benzamide, Cryptochrome-1 | Authors: | Miller, S, Aikawa, Y, Hirota, T. | Deposit date: | 2020-01-27 | Release date: | 2020-06-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals. Cell Chem Biol, 27, 2020
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1GCK
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![BU of 1gck by Molmil](/molmil-images/mine/1gck) | THERMUS THERMOPHILUS ASPARTATE AMINOTRANSFERASE DOUBLE MUTANT 1 COMPLEXED WITH ASPARTATE | Descriptor: | ASPARTATE AMINOTRANSFERASE, ASPARTIC ACID, PYRIDOXAL-5'-PHOSPHATE | Authors: | Ura, H, Nakai, T, Hirotsu, K, Kuramitsu, S. | Deposit date: | 2000-08-04 | Release date: | 2001-11-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Substrate recognition mechanism of thermophilic dual-substrate enzyme. J.Biochem., 130, 2001
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1GC4
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![BU of 1gc4 by Molmil](/molmil-images/mine/1gc4) | THERMUS THERMOPHILUS ASPARTATE AMINOTRANSFERASE TETRA MUTANT 2 COMPLEXED WITH ASPARTATE | Descriptor: | ASPARTATE AMINOTRANSFERASE, ASPARTIC ACID, PYRIDOXAL-5'-PHOSPHATE | Authors: | Ura, H, Nakai, T, Hirotsu, K, Kuramitsu, S. | Deposit date: | 2000-07-19 | Release date: | 2001-09-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Substrate recognition mechanism of thermophilic dual-substrate enzyme. J.Biochem., 130, 2001
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1GC3
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![BU of 1gc3 by Molmil](/molmil-images/mine/1gc3) | THERMUS THERMOPHILUS ASPARTATE AMINOTRANSFERASE TETRA MUTANT 2 COMPLEXED WITH TRYPTOPHAN | Descriptor: | ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, TRYPTOPHAN | Authors: | Ura, H, Nakai, T, Hirotsu, K, Kuramitsu, S. | Deposit date: | 2000-07-18 | Release date: | 2001-09-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Substrate recognition mechanism of thermophilic dual-substrate enzyme. J.Biochem., 130, 2001
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7F4B
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![BU of 7f4b by Molmil](/molmil-images/mine/7f4b) | The crystal structure of the immature apo-enzyme of homoserine dehydrogenase from the hyperthermophilic archaeon Sulfurisphaera tokodaii. | Descriptor: | MAGNESIUM ION, homoserine dehydrogenase | Authors: | Kurihara, E, Kubota, T, Watanabe, K, Ogata, K, Kaneko, R, Oshima, T, Yoshimune, K, Goto, M. | Deposit date: | 2021-06-18 | Release date: | 2022-06-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase. Commun Biol, 5, 2022
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7F4C
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![BU of 7f4c by Molmil](/molmil-images/mine/7f4c) | The crystal structure of the immature holo-enzyme of homoserine dehydrogenase complexed with NADP and 1,4-butandiol from the hyperthermophilic archaeon Sulfurisphaera tokodaii. | Descriptor: | 1,4-BUTANEDIOL, Homoserine dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Ogata, K, Kaneko, R, Kubota, T, Watanabe, K, Kurihara, E, Oshima, T, Yoshimune, K, Goto, M. | Deposit date: | 2021-06-18 | Release date: | 2022-06-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase. Commun Biol, 5, 2022
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4TZU
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![BU of 4tzu by Molmil](/molmil-images/mine/4tzu) | Crystal Structure of Murine Cereblon in Complex with Pomalidomide | Descriptor: | Protein cereblon, S-Pomalidomide, SULFATE ION, ... | Authors: | Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B. | Deposit date: | 2014-07-10 | Release date: | 2014-08-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex to be published
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4TZC
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![BU of 4tzc by Molmil](/molmil-images/mine/4tzc) | Crystal Structure of Murine Cereblon in Complex with Thalidomide | Descriptor: | Protein cereblon, S-Thalidomide, SULFATE ION, ... | Authors: | Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B. | Deposit date: | 2014-07-10 | Release date: | 2014-08-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex to be published
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4TZ4
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![BU of 4tz4 by Molmil](/molmil-images/mine/4tz4) | Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide | Descriptor: | DNA damage-binding protein 1, Protein cereblon, S-Lenalidomide, ... | Authors: | Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B, Riley, M. | Deposit date: | 2014-07-09 | Release date: | 2014-08-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex To Be Published
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4YH7
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![BU of 4yh7 by Molmil](/molmil-images/mine/4yh7) | Crystal structure of PTPdelta ectodomain in complex with IL1RAPL1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 receptor accessory protein-like 1, ... | Authors: | Yamagata, A, Fukai, S. | Deposit date: | 2015-02-27 | Release date: | 2015-05-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (4.4 Å) | Cite: | Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nat Commun, 6, 2015
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4YFE
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![BU of 4yfe by Molmil](/molmil-images/mine/4yfe) | Crystal structure of PTP delta Fn1-Fn2 | Descriptor: | Receptor-type tyrosine-protein phosphatase delta | Authors: | Yamagata, A, Fukai, S. | Deposit date: | 2015-02-25 | Release date: | 2015-05-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.972 Å) | Cite: | Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nat Commun, 6, 2015
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4YFG
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![BU of 4yfg by Molmil](/molmil-images/mine/4yfg) | Crystal structure of PTP delta meA3/meB minus variant Ig1-Fn1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor-type tyrosine-protein phosphatase delta | Authors: | Yamagata, A, Fukai, S. | Deposit date: | 2015-02-25 | Release date: | 2015-05-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.491 Å) | Cite: | Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nat Commun, 6, 2015
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4YH6
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![BU of 4yh6 by Molmil](/molmil-images/mine/4yh6) | Crystal structure of IL1RAPL1 ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 receptor accessory protein-like 1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yamagata, A, Fukai, S. | Deposit date: | 2015-02-27 | Release date: | 2015-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nat Commun, 6, 2015
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